Bioactive Materials, Год журнала: 2025, Номер 49, С. 362 - 377
Опубликована: Март 14, 2025
Язык: Английский
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Июль 1, 2024
The applications of hydrogels have expanded significantly due to their versatile, highly tunable properties and breakthroughs in biomaterial technologies. In this review, we cover the major achievements potential therapeutic applications, focusing primarily on two areas: emerging cell-based therapies promising non-cell modalities. Within context cell therapy, discuss capacity overcome existing translational challenges faced by mainstream therapy paradigms, provide a detailed discussion advantages principal design considerations for boosting efficacy as well list specific examples different disease scenarios. We then explore drug delivery, physical intervention therapies, other areas (e.g., bioadhesives, artificial tissues, biosensors), emphasizing utility beyond mere delivery vehicles. Additionally, complement our latest progress clinical application outline future research directions, particularly terms integration with advanced biomanufacturing This review aims present comprehensive view critical insights into selection both tailored meet requirements diverse diseases situations.
Язык: Английский
Процитировано
78
Advanced Materials, Год журнала: 2024, Номер 36(30)
Опубликована: Апрель 20, 2024
Abstract Addressing large bone defects remains a significant challenge owing to the inherent limitations in self‐healing capabilities, resulting prolonged recovery and suboptimal regeneration. Although current clinical solutions are available, they have notable shortcomings, necessitating more efficacious approaches Organoids derived from stem cells show great potential this field; however, development of organoids has been hindered by specific demands, including need for robust mechanical support provided scaffolds hybrid extracellular matrices (ECM). In context, bioprinting technologies emerged as powerful means replicating complex architecture tissue. The research focused on fabrication highly intricate ECM analog using novel bioink composed gelatin methacrylate/alginate methacrylate/hydroxyapatite (GelMA/AlgMA/HAP). Bioprinted facilitate long‐term cultivation progressive maturation extensive bioprinted organoids, foster multicellular differentiation, offer valuable insights into initial stages formation. intrinsic self‐mineralizing quality closely emulates properties natural bone, empowering with enhanced repair both vitro vivo applications. This trailblazing investigation propels field tissue engineering holds promise its translation practical
Язык: Английский
Процитировано
45
Bioactive Materials, Год журнала: 2024, Номер 38, С. 1 - 30
Опубликована: Апрель 23, 2024
Characterized by their pivotal roles in cell-to-cell communication, cell proliferation, and immune regulation during tissue repair, exosomes have emerged as a promising avenue for "cell-free therapy" clinical applications. Hydrogels, possessing commendable biocompatibility, degradability, adjustability, physical properties akin to biological tissues, also found extensive utility engineering regenerative repair. The synergistic combination of hydrogels holds the potential not only enhance efficiency but collaboratively advance repair process. This review has summarized advancements made over past decade research hydrogel-exosome systems regenerating various tissues including skin, bone, cartilage, nerves tendons, with focus on methods encapsulating releasing within hydrogels. It critically examined gaps limitations current research, whilst proposed future directions applications this innovative approach.
Язык: Английский
Процитировано
20
Advanced Healthcare Materials, Год журнала: 2024, Номер 13(22)
Опубликована: Май 21, 2024
The repair and regeneration of cartilage has always been a hot topic in medical research. Cartilage organoids (CORGs) are special tissue created using engineering techniques outside the body. These engineered tissues provide models that simulate complex biological functions cartilage, opening new possibilities for regenerative medicine treatment strategies. However, it is crucial to establish suitable matrix scaffolds cultivation CORGs. In recent years, utilizing hydrogel culture stem cells induce their differentiation into chondrocytes emerged as promising method vitro construction this review, methods establishing CORGs summarized an overview advantages limitations matrigel such provided. Furthermore, importance ECM alternative substitutes Matrigel, alginate, peptides, silk fibroin, DNA derivatives discussed, pros cons these hydrogels outlined. Finally, challenges future directions research discussed. It hoped article provides valuable references design development
Язык: Английский
Процитировано
20
Bioactive Materials, Год журнала: 2024, Номер 43, С. 1 - 31
Опубликована: Сен. 14, 2024
Язык: Английский
Процитировано
14
Chemical Engineering Journal, Год журнала: 2024, Номер 498, С. 155131 - 155131
Опубликована: Авг. 24, 2024
Язык: Английский
Процитировано
11
Advanced Functional Materials, Год журнала: 2024, Номер 34(28)
Опубликована: Май 31, 2024
Abstract 3D printing of articular cartilage tissue faces challenges like replicating its complex structure, time‐consuming in vitro stem cell culture, and a lack robust situ regeneration methods for osteochondral defects (OC). In response, an innovative approach utilizing pre‐designed bioink modular units one‐step immediate implantation is proposed, circumventing the need prior cultivation. The resulting printed scaffold not only accurately reproduces three‐layer structure material gradient but also attains impressive compressive strength (6.3 MPa) through reinforcement hydroxyapatite nanofibers establishment chemical bonds with hydrogels. Moreover, integrates capturing homing layers on bottom top via crosslinking aptamer loading poly (lactic‐co‐glycolic acid) (PLGA) nanospheres encapsulated stromal cell‐derived factor‐1α (SDF‐1α), respectively. This design enables specific capture bone marrow mesenchymal cells (BMSCs) vivo interaction, followed by their mobilization to home hyaline layer chemotaxis SDF‐1α concentration gradient. Within scaffold's microenvironment, these BMSCs undergo differentiation into distinct each layer, effectively contributing repair OC rabbits.
Язык: Английский
Процитировано
9
Advanced Healthcare Materials, Год журнала: 2024, Номер 13(28)
Опубликована: Июль 15, 2024
3D in vitro model has emerged as a valuable tool for studying tissue development, drug screening, and disease modeling. systems can accurately replicate microstructures physiological features, mirroring the vivo microenvironment departing from conventional 2D cell cultures. Various models utilizing biomacromolecules like collagen synthetic polymers have been developed to meet diverse research needs address complex challenges of contemporary research. Silk proteins, bearing structural functional similarities collagen, increasingly employed construct advanced systems, surpassing limitations This review examines silk proteins' composition, structure, properties, functions, elucidating their role models. Furthermore, recent advances biomedical applications involving silk-based organoid are discussed. In particular, unique attributes matrix constituents constructs highlighted, providing meticulous evaluation importance. Additionally, it outlines current hurdles complexities while contemplating future avenues, thereby paving way developing biomimetic protein-based microtissues.
Язык: Английский
Процитировано
8
Journal of Orthopaedic Translation, Год журнала: 2025, Номер 50, С. 111 - 128
Опубликована: Янв. 1, 2025
The treatment of orthopaedic diseases, such as fractures and osteoarthritis, remains a significant challenge due to the complex requirements for mechanical strength tissue repair. Hydrogels based on hyaluronic acid methacrylate (HAMA) show promise engineering materials these conditions. Hyaluronic (HA) is natural component extracellular matrix, known its good compatibility. HAMA-based hydrogels can be adjusted through crosslinking by combining them with other materials. This review provides an overview recent research applications in diseases. First, we summarize techniques preparation characterization HAMA hydrogels. Next, offer detailed use treating conditions cartilage injuries, bone defects, meniscus injuries. Additionally, discuss diseases related orthopaedics. Finally, point out challenges propose future directions clinical translation strong translational potential orthopaedics their biocompatibility, adjustable properties, regenerative capabilities. With ongoing research, are well-positioned applications, particularly repair, osteoarthritis treatment.
Язык: Английский
Процитировано
1
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 298, С. 140082 - 140082
Опубликована: Янв. 18, 2025
Язык: Английский
Процитировано
1