Carbohydrate Polymers, Год журнала: 2024, Номер 352, С. 123206 - 123206
Опубликована: Дек. 31, 2024
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(22), С. 12092 - 12092
Опубликована: Ноя. 11, 2024
Plant-derived exosome-like nanoparticles (PELNs) are a type of membranous vesicle isolated from plant tissues. They contain proteins, lipids, nucleic acids, and other components. PELNs involved in the defensive response to pathogen attacks by exerting anti-inflammatory, antiviral, antifibrotic, antitumor effects through substances they contain. Most edible can be used as carriers for delivering specific drugs without toxicity side effects, making them hot topic research. Sources abundantly, produced high yields, with low risk developing immunogenicity vivo. This paper summarizes formation, isolation, purification methods; physical properties; composition comprehensive literature search. It also analyzes biomedical applications PELNs, well future research directions. provides new ideas methods on PELNs.
Язык: Английский
Процитировано
4
Research, Год журнала: 2025, Номер 8
Опубликована: Янв. 1, 2025
The prevention of air pollution-related cardiopulmonary disorders has been largely overlooked despite its important burden. Extracellular vesicles (EVs) have shown great potential as carriers for drug delivery. However, the efficiency and effect EVs derived from different sources on ambient fine particulate matter (PM2.5)-induced injury remain unknown. Using PM2.5-exposed cellular mouse models, we investigated via an innovative strategy based EV By using a “2-step” method that combines bibliometric bioinformatic analysis, identified superoxide dismutase 2 ( Sod2 ) target PM2.5-induced injury. -overexpressing plasmid was constructed loaded into human plasma-, bovine milk-, fresh grape-derived EVs, ultimately obtaining modified nanoparticles including PEV , MEV GEV respectively. especially lyophilized powder, exhibited superior protection against compared to . High-sensitivity structured illumination microscopy imaging immunoblotting showed powder treatment altered lysosome positioning by reducing Rab-7 expression. Our findings support use fruit-derived preferred candidate nucleic acid delivery disease treatment, which may facilitate translation treatments injuries.
Язык: Английский
Процитировано
0
Molecular Biology Reports, Год журнала: 2025, Номер 52(1)
Опубликована: Фев. 13, 2025
Язык: Английский
Процитировано
0
Nano Biomedicine and Engineering, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 13
Опубликована: Фев. 27, 2025
Periodontitis is a chronic inflammatory disease affecting the supporting tissues of teeth and has emerged as global public health issue. Current therapies primarily address pathogenic factors alleviate symptoms, with limited options available for complete restoration reconstruction already absorbed periodontal bone tissue. In this study, we developed nanotherapeutic strategy utilizing fusion nanovesicles (FVs) to modulate microenvironment create regenerative niche ligament stem cells (PDLSCs), which play crucial role in tissue repair. The FVs are composed Scutellaria baicalensis (SBNVs) anti-Porphyromonas gingivalis (P. gingivalis) anti-inflammatory properties, combined PDLSC membrane-derived genetically engineered express TNFR1. These preserved biological activity SBNVs immunomodulatory function PDLSCs. Additionally, effectively captured cleared TNF-α from through Moreover, alleviated response PDLSCs induced by P. gingivalis-LPS (Pg-LPS) TNF-α, restoring their proliferation, migration, osteogenic differentiation capabilities. Hence, holds great potential treating periodontitis.
Язык: Английский
Процитировано
0
Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Март 6, 2025
Plant derived exosome-like nanoparticles (PELNs) are membrane structures isolated from different plants, which encapsulate many active substances such as proteins, lipids, and nucleic acids, exert a substantial influence on physiological processes plant growth development, self-defense, tissue repair. Compared with synthetic mammalian cell exosomes (MDEs), PELNs have lower toxicity immunogenicity possess excellent biocompatibility. The intrinsic properties of establish robust basis for their applications in the therapeutic management diverse array pathologies. It is worth mentioning that good biological targeting, promotes them to load deliver drugs specific tissues, offering superior development pathway construction new drug delivery system (DDS). Glucose lipid metabolism vital life process body's energy material supply. maintenance homeostatic balance provides fundamental ability adjust modifications both its internal external environment. Conversely, imbalance can lead range severe metabolic disorders. This work comprehensive overview extraction representation methods PELNs, transportation storage characteristics, agents direct treatment vehicles enhance nutrition health. Additionally, it examines efficacy practical addressing abnormalities glucose metabolism. Finally, combined above contents, paper summarizes conceptual framework better application clinical disease treatment.
Язык: Английский
Процитировано
0
Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Март 12, 2025
Excessive generation of reactive oxygen species is a hallmark the osteoporotic bone microenvironment, which leads to damage mitochondrial function and deactivation osteoblasts. Fruits vegetables are rich sources antioxidants, play key role in scavenging free radicals maintaining body's homeostasis. Herein, we have developed type vesicle coming from carrots as nanoantioxidants counteract oxidative stress restore vitality osteoblasts for reversing osteoporosis. Nanovesicles derived carrot juice using straightforward extrusion method, resulting stable membrane structures containing various lipids homologous active phytochemicals. can maintain under normal physiological conditions (pH 7.4) transform into aggregates response acidic extracellular pH osteoporosis 4.0). As anticipated, nanovesicles passively target aggregate bone, ease stress, function, promote osteoblastogenesis, reduce loss mice. This work presents first demonstration novel realize long-awaited osteogenesis, contributing exploration brand-new idea
Язык: Английский
Процитировано
0
Molecular and Cellular Biochemistry, Год журнала: 2025, Номер unknown
Опубликована: Март 17, 2025
Язык: Английский
Процитировано
0
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 161896 - 161896
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Pharmacology, Год журнала: 2025, Номер 16
Опубликована: Март 27, 2025
The treatment of ovarian cancer is hindered by its insidious onset and rapid progression. Exosomes (EXOs) present a promising therapeutic strategy for modulating the tumor microenvironment. However, concerns regarding biosafety animal-derived EXOs pose significant challenges to development innovative formulations. In this study, we propose universal engineer plant-derived as microenvironment nanoregulators targeted therapy. derived from ginger were purified, loaded with natural bioactive compound curcumin (Cur) high encapsulation efficiency, functionalized tumor-targeting aptamer. Upon intravenous administration, resulting multifaceted nanoregulator, termed AGE@Cur, effectively accumulates at site exerts tumor-suppressive effect through remodeling This novel platform not only addresses limitations but also paves way regulators in clinical applications.
Язык: Английский
Процитировано
0