Mice and primates use distinct strategies for visual segmentation DOI Creative Commons
Francisco J. Luongo, Lu Liu,

Chun Lum Andy Ho

и другие.

eLife, Год журнала: 2023, Номер 12

Опубликована: Фев. 15, 2023

The rodent visual system has attracted great interest in recent years due to its experimental tractability, but the fundamental mechanisms used by mouse represent world remain unclear. In primate, researchers have argued from both behavioral and neural evidence that a key step representation is ‘figure-ground segmentation’, delineation of figures as distinct backgrounds. To determine if mice also show signatures figure-ground segmentation, we trained on segmentation task where were defined gratings naturalistic textures moving counterphase background. Unlike primates, severely limited their ability segment figure ground using opponent motion cue, with behavior strongly dependent specific carrier pattern. Remarkably, when forced localize patterns motion, they adopted strategy brute force memorization texture patterns. contrast, including humans, macaques, lemurs, could readily independent pattern cue. Consistent behavior, responses same stimuli recorded areas V1, RL, LM did not support texture-invariant motion. Modeling revealed dependence mouse’s be explained feedforward network lacking explicit capabilities. These findings reveal limitation objects compared primates.

Язык: Английский

Understanding the retinal basis of vision across species DOI
Tom Baden, Thomas Euler, Philipp Berens

и другие.

Nature reviews. Neuroscience, Год журнала: 2019, Номер 21(1), С. 5 - 20

Опубликована: Ноя. 28, 2019

Язык: Английский

Процитировано

282
Functional Circuitry of the Retina DOI
Jonathan B. Demb, Joshua H. Singer

Annual Review of Vision Science, Год журнала: 2015, Номер 1(1), С. 263 - 289

Опубликована: Ноя. 18, 2015

The mammalian retina is an important model system for studying neural circuitry: Its role in sensation clear, its cell types are relatively well defined, and responses to natural stimuli—light patterns—can be studied vitro. To solve the retina, we need understand how circuits presynaptic output neurons, ganglion cells, divide visual scene into parallel representations assembled interpreted by brain. This requires identifying component interneurons understanding their intrinsic properties synapses generate circuit behaviors. Because cellular composition fundamental of shared across species, basic mechanisms genetically modifiable mouse apply primate vision. We propose that apparent complexity retinal computation derives from a straightforward mechanism—a dynamic balance synaptic excitation inhibition regulated use-dependent depression—applied differentially pathways feed cells.

Язык: Английский

Процитировано

187
Inhibitory Interneurons in the Retina: Types, Circuitry, and Function DOI
Jeffrey S. Diamond

Annual Review of Vision Science, Год журнала: 2017, Номер 3(1), С. 1 - 24

Опубликована: Июнь 15, 2017

Visual signals in the vertebrate retina are shaped by feedback and feedforward inhibition two synaptic layers. In one, horizontal cells establish fundamental center-surround receptive-field properties via morphologically physiologically complex synapses with photoreceptors bipolar cells. other, a panoply of amacrine imbue ganglion cell responses spatiotemporally information about visual world. Here, I review current ideas signaling, considering evidence for against leading, competing theories. also discuss recent work that has begun to make sense remarkable morphological physiological diversity These latter efforts have been aided tremendously increasingly complete connectivity maps inner retinal circuitry new genetic tools enable study individual, sparsely expressed types.

Язык: Английский

Процитировано

174
Cell types and cell circuits in human and non-human primate retina DOI Creative Commons
Ulrike Grünert, Paul R. Martin

Progress in Retinal and Eye Research, Год журнала: 2020, Номер 78, С. 100844 - 100844

Опубликована: Фев. 5, 2020

This review summarizes our current knowledge of primate including human retina focusing on bipolar, amacrine and ganglion cells their connectivity. We have two main motivations in writing. Firstly, recent progress non-invasive imaging methods to study retinal diseases mean that better understanding the is becoming an important goal both for basic clinical sciences. Secondly, genetically modified mice are increasingly used as animal models diseases. Thus, it understand which extent retinas primates rodents comparable. first compare cell populations rodent retinas, with emphasis how fovea (despite its small size) dominates neural landscape retina. next summarise what known, not about postreceptoral neurone The inventories bipolar now nearing completion, comprising ~12 types at least 17 cell. Primate show clear differences dendritic field size across retina, morphology differs clearly from mouse cells. Compared cells, even higher morphological diversity: they could comprise over 40 types. Many appear conserved between mice, but functions only a few understood any or non-primate Amacrine final frontier research monkeys alike.

Язык: Английский

Процитировано

145
Sidekick 2 directs formation of a retinal circuit that detects differential motion DOI
Arjun Krishnaswamy, Masahito Yamagata, Xin Duan

и другие.

Nature, Год журнала: 2015, Номер 524(7566), С. 466 - 470

Опубликована: Авг. 18, 2015

Язык: Английский

Процитировано

167
Neural Mechanisms of Motion Processing in the Mammalian Retina DOI Creative Commons
Wei Wei

Annual Review of Vision Science, Год журнала: 2018, Номер 4(1), С. 165 - 192

Опубликована: Авг. 10, 2018

Visual motion on the retina activates a cohort of retinal ganglion cells (RGCs). This population activity encodes multiple streams information extracted by parallel circuits. Motion processing in is best studied direction-selective circuit. The main focus this review neural basis direction selectivity, which has been investigated unprecedented detail using state-of-the-art functional, connectomic, and modeling methods. Mechanisms underlying encoding other features broader RGC populations are also discussed. Recent discoveries at both single-cell levels highlight dynamic stimulus-dependent engagement mechanisms that collectively implement robust detection under diverse visual conditions.

Язык: Английский

Процитировано

108
Segregated Glycine-Glutamate Co-transmission from vGluT3 Amacrine Cells to Contrast-Suppressed and Contrast-Enhanced Retinal Circuits DOI Creative Commons
Seung‐Hoon Lee, Yi Zhang, Minggang Chen

и другие.

Neuron, Год журнала: 2016, Номер 90(1), С. 27 - 34

Опубликована: Март 17, 2016

Язык: Английский

Процитировано

96
Glutamatergic Monopolar Interneurons Provide a Novel Pathway of Excitation in the Mouse Retina DOI Creative Commons
Luca Della Santina,

Sidney P. Kuo,

Takeshi Yoshimatsu

и другие.

Current Biology, Год журнала: 2016, Номер 26(15), С. 2070 - 2077

Опубликована: Июль 16, 2016

Язык: Английский

Процитировано

93
Three Small-Receptive-Field Ganglion Cells in the Mouse Retina Are Distinctly Tuned to Size, Speed, and Object Motion DOI Creative Commons
Jason Jacoby, Gregory W. Schwartz

Journal of Neuroscience, Год журнала: 2016, Номер 37(3), С. 610 - 625

Опубликована: Дек. 5, 2016

Retinal ganglion cells (RGCs) are frequently divided into functional types by their ability to extract and relay specific features from a visual scene, such as the capacity discern local or global motion, direction of stimulus orientation, contrast uniformity, presence large small objects. Here we introduce three previously uncharacterized, nondirection-selective ON–OFF RGC that represent distinct set feature detectors in mouse retina. The high-definition (HD) RGCs possess receptive-field centers strong surround suppression. They respond selectively objects sizes, speeds, motion. We present comprehensive morphological characterization HD physiological recordings light responses, size structure, synaptic mechanisms also explore similarities differences between well characterized with comparably receptive field, edge detector, response moving textures. model populations each type study how they differ performance tracking object. These results, besides introducing new together constitute substantial fraction RGCs, provide insights role different circuits shaping fields establish foundation for continued suppression neural basis motion detection. SIGNIFICANCE STATEMENT output retina, retinal (RGCs), diverse group ∼40 neuron often assigned “feature detection” profiles based on aspects scene which respond. describe, first time, substantially augmenting our understanding selectivity. Experiments modeling show while these “high-definition” share certain properties, have tuning size, speed, enabling them occupy niches space.

Язык: Английский

Процитировано

89
A Central Role for Mixed Acetylcholine/GABA Transmission in Direction Coding in the Retina DOI Creative Commons
Santhosh Sethuramanujam,

Amanda J. McLaughlin,

Geoff deRosenroll

и другие.

Neuron, Год журнала: 2016, Номер 90(6), С. 1243 - 1256

Опубликована: Май 28, 2016

Язык: Английский

Процитировано

87