Animal Diseases, Год журнала: 2025, Номер 5(1)

Опубликована: Апрель 27, 2025

Abstract Coinfection, the simultaneous invasion of multiple pathogens into a single host, is critical but understudied area, especially in farm animal sector. We report unique and unusual fatal case coinfection with S . Indiana Kentucky, which has rarely been studied literature could hold potential importance for veterinary clinics. In silico analysis revealed that all isolates exhibited extensive multidrug resistance. By analyzing plasmids, two replicons, IncHI2 IncHI2A, were detected Indiana, whereas no plasmids Kentucky. Chicken embryo lethality assays demonstrated both Kentucky caused 100% mortality by third day post infection, significantly exceeding control strains. These findings emphasize high pathogenic these serovars, carries cdtB gene encoding typhoid toxin, further confirming its increased pathogenicity. Overall, our results underscore urgent need to improve biosecurity measures mitigate risk coinfections involving multidrug-resistant Salmonella strains poultry production environments.

Язык: Английский