Computational Neuroethology: A Call to Action

Neuron, Год журнала: 2019, Номер 104(1), С. 11 - 24

Опубликована: Окт. 1, 2019

Язык: Английский

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Circuit modules linking internal states and social behaviour in flies and mice

Nature reviews. Neuroscience, Год журнала: 2016, Номер 17(11), С. 692 - 704

Опубликована: Окт. 18, 2016

Язык: Английский

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Integration of Parallel Opposing Memories Underlies Memory Extinction

Cell, Год журнала: 2018, Номер 175(3), С. 709 - 722.e15

Опубликована: Сен. 20, 2018

Accurately predicting an outcome requires that animals learn supporting and conflicting evidence from sequential experience. In mammals invertebrates, learned fear responses can be suppressed by experiencing predictive cues without punishment, a process called memory extinction. Here, we show extinction of aversive memories in Drosophila specific dopaminergic neurons, which indicate omission punishment is remembered as positive Functional imaging revealed co-existence intracellular calcium traces different places the mushroom body output neuron network for both original new appetitive memory. Light ultrastructural anatomy are consistent with parallel competing being combined within neurons direct avoidance. Indeed, extinction-evoked plasticity pair these neutralizes potentiated odor response imposed learning. Therefore, flies track accuracy expectations accumulating integrating events.

Язык: Английский

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Mapping the Neural Substrates of Behavior

Cell, Год журнала: 2017, Номер 170(2), С. 393 - 406.e28

Опубликована: Июль 1, 2017

Язык: Английский

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Aversive Learning and Appetitive Motivation Toggle Feed-Forward Inhibition in the Drosophila Mushroom Body

Neuron, Год журнала: 2016, Номер 90(5), С. 1086 - 1099

Опубликована: Май 21, 2016

In Drosophila, negatively reinforcing dopaminergic neurons also provide the inhibitory control of satiety over appetitive memory expression. Here we show that aversive learning causes a persistent depression conditioned odor drive to two downstream feed-forward GABAergic interneurons mushroom body, called MVP2, or body output neuron (MBON)-γ1pedc>α/β. However, MVP2 is only essential for expression short-term memory. Stimulating preferentially inhibits odor-evoked activity avoidance-directing MBONs and odor-driven avoidance behavior, whereas their inhibition enhances avoidance. contrast, elevated in hungry flies, required at all times. Moreover, imposing promotes inappropriate food-satiated flies. Aversive motivation therefore toggle alternate modes common pathway promote approach.

Язык: Английский

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Unsupervised identification of the internal states that shape natural behavior

Nature Neuroscience, Год журнала: 2019, Номер 22(12), С. 2040 - 2049

Опубликована: Ноя. 25, 2019

Язык: Английский

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Drosophila mushroom bodies integrate hunger and satiety signals to control innate food-seeking behavior

eLife, Год журнала: 2018, Номер 7

Опубликована: Март 16, 2018

The fruit fly can evaluate its energy state and decide whether to pursue food-related cues. Here, we reveal that the mushroom body (MB) integrates hunger satiety signals control food-seeking behavior. We have discovered five pathways in MB essential for hungry flies locate approach food. Blocking MB-intrinsic Kenyon cells (KCs) output neurons (MBONs) these impairs Starvation bi-directionally modulates MBON responses a food odor, suggesting controls occur at KC-to-MBON synapses. These are mediated by six types of dopaminergic (DANs). By manipulating DANs, could inhibit behavior or promote seeking fed flies. Finally, show DANs potentially receive multiple inputs signals. This work demonstrates an information-rich central circuit brain hunger-driven

Язык: Английский

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Hunger neurons drive feeding through a sustained, positive reinforcement signal

eLife, Год журнала: 2016, Номер 5

Опубликована: Авг. 24, 2016

The neural mechanisms underlying hunger are poorly understood. AgRP neurons activated by energy deficit and promote voracious food consumption, suggesting these cells may supply the fundamental drive that motivates feeding. However recent in vivo recording experiments revealed inhibited within seconds sensory detection of food, raising question how can feeding at all. Here we resolve this paradox showing brief optogenetic stimulation before availability promotes intense appetitive consummatory behaviors persist for tens minutes absence continued neuron activation. We show sustained behavioral responses mediated a long-lasting potentiation rewarding properties activity is positively reinforcing. These findings reveal transmitting positive valence signal triggers stable transition between states.

Язык: Английский

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Sensorimotor experience remaps visual input to a heading-direction network

Nature, Год журнала: 2019, Номер 576(7785), С. 121 - 125

Опубликована: Ноя. 20, 2019

Язык: Английский

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The emergence and influence of internal states

Neuron, Год журнала: 2022, Номер 110(16), С. 2545 - 2570

Опубликована: Май 27, 2022

Язык: Английский

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