Biomolecules,
Год журнала:
2025,
Номер
15(5), С. 672 - 672
Опубликована: Май 6, 2025
Neural
stem
cells
(NSC)
are
multipotent,
self-renewing
that
give
rise
to
all
neural
cell
types
within
the
central
nervous
system.
During
adulthood,
most
NSCs
exist
in
a
quiescent
state
which
can
be
reactivated
response
metabolic
and
signalling
changes,
allowing
for
long-term
continuous
neurogenesis
injury.
Ensuring
critical
balance
between
quiescence
reactivation
is
required
maintain
limited
NSC
reservoir
replenishment
throughout
lifetime.
The
precise
mechanisms
pathways
behind
this
at
focus
of
current
research.
In
review,
we
highlight
discuss
recent
studies
using
Drosophila,
mammalian
zebrafish
models
contributing
understanding
molecular
underlying
NSCs.
Stem
cell
niche
is
critical
for
regulating
the
behavior
of
stem
cells.
Drosophila
neural
cells
(Neuroblasts,
NBs)
are
encased
by
glial
closely,
but
it
still
remains
unclear
whether
can
regulate
self-renewal
and
differentiation
NBs.
Here,
we
show
that
ferritin
produced
glia,
cooperates
with
Zip13
to
transport
iron
into
NBs
energy
production,
which
essential
proliferation
The
knockdown
encoding
genes
causes
shortage
in
via
downregulating
aconitase
activity
NAD
+
level,
leads
low
premature
mediated
Prospero
entering
nuclei.
More
importantly,
a
potential
target
tumor
suppression.
In
addition,
level
production
affected
status
NBs,
establishing
bicellular
homeostasis.
this
study,
demonstrate
indispensable
maintain
unveiling
novel
role
NB
during
brain
development.
The
Drosophila
melanogaster
brain
is
a
complex
organ
with
various
cell
types,
orchestrating
the
development,
physiology,
and
behaviors
of
fly.
While
each
type
in
known
to
express
unique
gene
set,
their
complete
genetic
profile
still
unknown.
Advances
RNA
sequencing
techniques
at
single-cell
resolution
facilitate
identifying
novel
markers
and/or
re-examining
specificity
available
ones.
In
this
study,
exploiting
data
optic
lobe,
we
categorized
cells
based
on
expression
pattern
for
markers,
then
genes
enriched
astrocytes
were
identified.
CG11000
was
identified
as
comparable
Eaat1
gene,
an
astrocyte
marker,
every
individual
inside
lobe
midbrain,
well
entire
throughout
its
development.
Consistent
our
bioinformatics
data,
immunostaining
brains
dissected
from
transgenic
adult
flies
showed
co-expression
set
single
corresponding
brain.
Physiologically,
inhibiting
through
interference
disrupted
normal
development
male
D.
melanogaster,
while
having
no
impact
females.
Expression
suppression
led
decreased
locomotion
activity
also
shortened
lifespan
specifically
astrocytes,
indicating
gene's
significance
astrocytes.
We
designated
'deathstar'
due
crucial
role
maintaining
star-like
shape
glial
cells,
into
stage.
Biomolecules,
Год журнала:
2025,
Номер
15(5), С. 672 - 672
Опубликована: Май 6, 2025
Neural
stem
cells
(NSC)
are
multipotent,
self-renewing
that
give
rise
to
all
neural
cell
types
within
the
central
nervous
system.
During
adulthood,
most
NSCs
exist
in
a
quiescent
state
which
can
be
reactivated
response
metabolic
and
signalling
changes,
allowing
for
long-term
continuous
neurogenesis
injury.
Ensuring
critical
balance
between
quiescence
reactivation
is
required
maintain
limited
NSC
reservoir
replenishment
throughout
lifetime.
The
precise
mechanisms
pathways
behind
this
at
focus
of
current
research.
In
review,
we
highlight
discuss
recent
studies
using
Drosophila,
mammalian
zebrafish
models
contributing
understanding
molecular
underlying
NSCs.
