Cell, Год журнала: 2024, Номер 187(18), С. 4877 - 4889.e15
Опубликована: Авг. 1, 2024
Язык: Английский
Cell, Год журнала: 2020, Номер 181(5), С. 978 - 989
Опубликована: Май 1, 2020
Язык: Английский
Процитировано
750
The Plant Cell, Год журнала: 2022, Номер 34(5), С. 1447 - 1478
Опубликована: Фев. 10, 2022
Understanding the plant immune system is crucial for using genetics to protect crops from diseases. Plants resist pathogens via a two-tiered innate detection-and-response system. The first Resistance (R) gene was cloned in 1992 . Since then, many cell-surface pattern recognition receptors (PRRs) have been identified, and R genes that encode intracellular nucleotide-binding leucine-rich repeat (NLRs) cloned. Here, we provide list of characterized PRRs NLRs. In addition receptors, components signaling networks were discovered over last 30 years. We review pathways, physiological responses, molecular regulation both PRR- NLR-mediated immunity. Recent studies reinforced importance interactions between two systems. an overview immunity, highlighting challenges perspectives future research.
Язык: Английский
Процитировано
575
Cell, Год журнала: 2021, Номер 184(13), С. 3528 - 3541.e12
Опубликована: Май 12, 2021
Язык: Английский
Процитировано
434
Science, Год журнала: 2020, Номер 370(6521)
Опубликована: Дек. 4, 2020
Tetrameric immune receptors Nucleotide-binding/leucine-rich repeat (NLR) detect pathogen effectors and trigger a plant's response. Two groups have now defined the structures of two NLRs that carry Toll-like interleukin-1 receptor (TIR) domains (TIR-NLRs) (see Perspective by Tian Li). Ma et al. studied Arabidopsis thaliana TIR-NLR RPP1 (recognition Peronospora parasitica 1) its response to from an oomycete pathogen. Martin Nicotiana benthamiana ROQ1 XopQ Xanthomonas effector. Both found these TIR-NLRs formed tetramers that, when activated binding effector, exposed active site nicotinamide adenine dinucleoside (NAD) hydrolase. Thus, recognition effector initiates NAD hydrolysis begins Science , this issue p. eabe3069 eabd9993 ; see also 1163
Язык: Английский
Процитировано
400
Science, Год журнала: 2021, Номер 373(6553), С. 420 - 425
Опубликована: Июнь 17, 2021
Plant nucleotide-binding leucine-rich repeat receptors (NLRs) regulate immunity and cell death. In
Язык: Английский
Процитировано
292
Trends in Plant Science, Год журнала: 2021, Номер 27(3), С. 255 - 273
Опубликована: Сен. 18, 2021
Язык: Английский
Процитировано
230
Nature, Год журнала: 2022, Номер 610(7932), С. 532 - 539
Опубликована: Сен. 26, 2022
Abstract Plant intracellular nucleotide-binding leucine-rich repeat receptors (NLRs) detect pathogen effectors to trigger immune responses 1 . Indirect recognition of a effector by the dicotyledonous Arabidopsis thaliana coiled-coil domain containing NLR (CNL) ZAR1 induces formation large hetero-oligomeric protein complex, termed resistosome, which functions as calcium channel required for ZAR1-mediated immunity 2–4 Whether resistosome and activities are conserved among plant CNLs remains unknown. Here we report cryo-electron microscopy structure wheat CNL Sr35 5 in complex with AvrSr35 6 stem rust pathogen. Direct binding repeats results pentameric Sr35–AvrSr35 term resistosome. Wheat resistosomes bear striking structural similarities, including an arginine cluster not previously recognized conserved, co-occurs forms intramolecular interactions 'EDVID' motif domain. Electrophysiological measurements show that exhibits non-selective cation activity. These insights allowed us generate new variants closely related barley orphan NLRs recognize AvrSr35. Our data support evolutionary conservation plants demonstrate proof principle structure-based engineering crop improvement.
Язык: Английский
Процитировано
194
Annual Review of Phytopathology, Год журнала: 2020, Номер 58(1), С. 253 - 276
Опубликована: Май 12, 2020
The EDS1 family of structurally unique lipase-like proteins EDS1, SAG101, and PAD4 evolved in seed plants, on top existing phytohormone nucleotide-binding-leucine-rich-repeat (NLR) networks, to regulate immunity pathways against host-adapted biotrophic pathogens. Exclusive heterodimers between SAG101 or create essential surfaces for resistance signaling. Phylogenomic information, together with functional studies Arabidopsis tobacco, identify a coevolved module the EDS1-SAG101 heterodimer coiled-coil (CC) HET-S LOP-B (CCHELO) domain helper NLRs that is recruited by intracellular Toll-interleukin1-receptor (TIR) NLR receptors confer host cell death pathogen immunity. EDS1-PAD4 have different broader activity basal transcriptionally reinforces local systemic defenses triggered various NLRs. Here, we consider protein functions across plant lineages context networking receptor downstream machineries. modes action pathway connectivities members go some way explaining their central role biotic stress resilience.
Язык: Английский
Процитировано
155
Nature reviews. Immunology, Год журнала: 2020, Номер 21(5), С. 305 - 318
Опубликована: Дек. 8, 2020
Язык: Английский
Процитировано
151
Annual Review of Plant Biology, Год журнала: 2020, Номер 71(1), С. 355 - 378
Опубликована: Фев. 24, 2020
Nucleotide-binding leucine-rich repeat receptors (NLRs) monitor the plant intracellular environment for signs of pathogen infection. Several mechanisms NLR-mediated immunity arose independently across multiple species. These include functional specialization NLRs into sensors and helpers, independent emergence direct indirect recognition within NLR subfamilies, regulation by small RNAs, formation networks. Understanding evolutionary history can shed light on both origin common constraints immune system. Attempts to engineer disease resistance have been sparse rarely informed knowledge. In this review, we discuss evolution NLRs, give an overview previous engineering attempts, propose how use knowledge advance future research in generation novel disease-recognition capabilities.
Язык: Английский
Процитировано
145