Cell, Journal Year: 2024, Volume and Issue: 187(18), P. 4877 - 4889.e15
Published: Aug. 1, 2024
Language: Английский
Cell, Journal Year: 2020, Volume and Issue: 181(5), P. 978 - 989
Published: May 1, 2020
Language: Английский
Citations
745
The Plant Cell, Journal Year: 2022, Volume and Issue: 34(5), P. 1447 - 1478
Published: Feb. 10, 2022
Understanding the plant immune system is crucial for using genetics to protect crops from diseases. Plants resist pathogens via a two-tiered innate detection-and-response system. The first Resistance (R) gene was cloned in 1992 . Since then, many cell-surface pattern recognition receptors (PRRs) have been identified, and R genes that encode intracellular nucleotide-binding leucine-rich repeat (NLRs) cloned. Here, we provide list of characterized PRRs NLRs. In addition receptors, components signaling networks were discovered over last 30 years. We review pathways, physiological responses, molecular regulation both PRR- NLR-mediated immunity. Recent studies reinforced importance interactions between two systems. an overview immunity, highlighting challenges perspectives future research.
Language: Английский
Citations
569
Cell, Journal Year: 2021, Volume and Issue: 184(13), P. 3528 - 3541.e12
Published: May 12, 2021
Language: Английский
Citations
434
Science, Journal Year: 2020, Volume and Issue: 370(6521)
Published: Dec. 4, 2020
Tetrameric immune receptors Nucleotide-binding/leucine-rich repeat (NLR) detect pathogen effectors and trigger a plant's response. Two groups have now defined the structures of two NLRs that carry Toll-like interleukin-1 receptor (TIR) domains (TIR-NLRs) (see Perspective by Tian Li). Ma et al. studied Arabidopsis thaliana TIR-NLR RPP1 (recognition Peronospora parasitica 1) its response to from an oomycete pathogen. Martin Nicotiana benthamiana ROQ1 XopQ Xanthomonas effector. Both found these TIR-NLRs formed tetramers that, when activated binding effector, exposed active site nicotinamide adenine dinucleoside (NAD) hydrolase. Thus, recognition effector initiates NAD hydrolysis begins Science , this issue p. eabe3069 eabd9993 ; see also 1163
Language: Английский
Citations
399
Science, Journal Year: 2021, Volume and Issue: 373(6553), P. 420 - 425
Published: June 17, 2021
Plant nucleotide-binding leucine-rich repeat receptors (NLRs) regulate immunity and cell death. In
Language: Английский
Citations
290
Trends in Plant Science, Journal Year: 2021, Volume and Issue: 27(3), P. 255 - 273
Published: Sept. 18, 2021
Language: Английский
Citations
228
Nature, Journal Year: 2022, Volume and Issue: 610(7932), P. 532 - 539
Published: Sept. 26, 2022
Abstract Plant intracellular nucleotide-binding leucine-rich repeat receptors (NLRs) detect pathogen effectors to trigger immune responses 1 . Indirect recognition of a effector by the dicotyledonous Arabidopsis thaliana coiled-coil domain containing NLR (CNL) ZAR1 induces formation large hetero-oligomeric protein complex, termed resistosome, which functions as calcium channel required for ZAR1-mediated immunity 2–4 Whether resistosome and activities are conserved among plant CNLs remains unknown. Here we report cryo-electron microscopy structure wheat CNL Sr35 5 in complex with AvrSr35 6 stem rust pathogen. Direct binding repeats results pentameric Sr35–AvrSr35 term resistosome. Wheat resistosomes bear striking structural similarities, including an arginine cluster not previously recognized conserved, co-occurs forms intramolecular interactions 'EDVID' motif domain. Electrophysiological measurements show that exhibits non-selective cation activity. These insights allowed us generate new variants closely related barley orphan NLRs recognize AvrSr35. Our data support evolutionary conservation plants demonstrate proof principle structure-based engineering crop improvement.
Language: Английский
Citations
193
Annual Review of Phytopathology, Journal Year: 2020, Volume and Issue: 58(1), P. 253 - 276
Published: May 12, 2020
The EDS1 family of structurally unique lipase-like proteins EDS1, SAG101, and PAD4 evolved in seed plants, on top existing phytohormone nucleotide-binding-leucine-rich-repeat (NLR) networks, to regulate immunity pathways against host-adapted biotrophic pathogens. Exclusive heterodimers between SAG101 or create essential surfaces for resistance signaling. Phylogenomic information, together with functional studies Arabidopsis tobacco, identify a coevolved module the EDS1-SAG101 heterodimer coiled-coil (CC) HET-S LOP-B (CCHELO) domain helper NLRs that is recruited by intracellular Toll-interleukin1-receptor (TIR) NLR receptors confer host cell death pathogen immunity. EDS1-PAD4 have different broader activity basal transcriptionally reinforces local systemic defenses triggered various NLRs. Here, we consider protein functions across plant lineages context networking receptor downstream machineries. modes action pathway connectivities members go some way explaining their central role biotic stress resilience.
Language: Английский
Citations
153
Nature reviews. Immunology, Journal Year: 2020, Volume and Issue: 21(5), P. 305 - 318
Published: Dec. 8, 2020
Language: Английский
Citations
149
Annual Review of Plant Biology, Journal Year: 2020, Volume and Issue: 71(1), P. 355 - 378
Published: Feb. 24, 2020
Nucleotide-binding leucine-rich repeat receptors (NLRs) monitor the plant intracellular environment for signs of pathogen infection. Several mechanisms NLR-mediated immunity arose independently across multiple species. These include functional specialization NLRs into sensors and helpers, independent emergence direct indirect recognition within NLR subfamilies, regulation by small RNAs, formation networks. Understanding evolutionary history can shed light on both origin common constraints immune system. Attempts to engineer disease resistance have been sparse rarely informed knowledge. In this review, we discuss evolution NLRs, give an overview previous engineering attempts, propose how use knowledge advance future research in generation novel disease-recognition capabilities.
Language: Английский
Citations
145