Deep brain stimulation of the central thalamus restores arousal and motivation in a zolpidem-responsive patient with akinetic mutism after severe brain injury DOI Creative Commons
Hisse Arnts, Prejaas Tewarie, Willemijn S. van Erp

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Фев. 5, 2024

Abstract After severe brain injury, zolpidem is known to cause spectacular, often short-lived, restorations of functions in a small subgroup patients. Previously, we showed that these zolpidem-induced neurological recoveries can be paralleled by significant changes functional connectivity throughout the brain. Deep stimulation (DBS) neurosurgical intervention modulate wide variety disorders. In this study, used DBS restore arousal and motivation zolpidem-responsive patient with injury concomitant disorder diminished motivation, more than 10 years after surviving hypoxic ischemia. We found central thalamus, targeted at centromedian-parafascicular complex, immediately restored was able transition from state deep sleep full wakefulness. Moreover, associated temporary restoration communication ability walk eat an otherwise wheelchair-bound mute patient. With use magnetoencephalography (MEG), revealed generally marked decrease aberrantly high levels brain, mimicking effects zolpidem. These results imply ‘pathological hyperconnectivity’ reduced behavioral performance towards ‘healthier baseline’ lower synchronization, and, networks long injury. The presence hyperconnectivity may possible future marker for patient’s responsiveness restorative interventions, such as DBS, suggests degrees overall synchronization conducive cognition responsiveness.

Язык: Английский

Neuromodulation of Brain State and Behavior DOI Open Access
David A. McCormick, Dennis Nestvogel, Biyu J. He

и другие.

Annual Review of Neuroscience, Год журнала: 2020, Номер 43(1), С. 391 - 415

Опубликована: Апрель 6, 2020

Neural activity and behavior are both notoriously variable, with responses differing widely between repeated presentation of identical stimuli or trials. Recent results in humans animals reveal that these variations not random their nature, but may fact be due large part to rapid shifts neural, cognitive, behavioral states. Here we review recent advances the understanding waking state, how generated, they modulate neural mice humans. We propose brain has an identifiable set states through which it wanders continuously a nonrandom fashion, owing ascending modulatory fast-acting corticocortical subcortical-cortical pathways. These state provide backdrop upon operates, them is critical making progress revealing mechanisms underlying cognition behavior.

Язык: Английский

Процитировано

253
Behavior needs neural variability DOI Creative Commons
Leonhard Waschke, Niels A Kloosterman, Jonas Obleser

и другие.

Neuron, Год журнала: 2021, Номер 109(5), С. 751 - 766

Опубликована: Фев. 17, 2021

Язык: Английский

Процитировано

234
Modality-specific tracking of attention and sensory statistics in the human electrophysiological spectral exponent DOI Creative Commons
Leonhard Waschke, Thomas Donoghue, Lorenz Fiedler

и другие.

eLife, Год журнала: 2021, Номер 10

Опубликована: Окт. 21, 2021

A hallmark of electrophysiological brain activity is its 1/f-like spectrum – power decreases with increasing frequency. The steepness this ‘roll-off’ approximated by the spectral exponent, which in invasively recorded neural populations reflects balance excitatory to inhibitory (E:I balance). Here, we first establish that exponent non-invasive electroencephalography (EEG) recordings highly sensitive general (i.e., anaesthesia-driven) changes E:I balance. Building on EEG as a viable marker E:I, then demonstrate sensitivity focus selective attention an experiment during participants detected targets simultaneous audio-visual noise. In addition these endogenous balance, exponents over auditory and visual sensory cortices also tracked stimulus exponents, respectively. Individuals’ degree stimulus–brain coupling predicted behavioural performance. Our results highlight rich information contained activity, providing window into diverse processes previously thought be inaccessible human recordings.

Язык: Английский

Процитировано

182
Transcutaneous Vagus Nerve Stimulation in Humans Induces Pupil Dilation and Attenuates Alpha Oscillations DOI Creative Commons
O. Sharon, Firas Fahoum, Yuval Nir

и другие.

Journal of Neuroscience, Год журнала: 2020, Номер 41(2), С. 320 - 330

Опубликована: Ноя. 19, 2020

Vagus nerve stimulation (VNS) is widely used to treat drug-resistant epilepsy and depression. While the precise mechanisms mediating its long-term therapeutic effects are not fully resolved, they likely involve locus coeruleus (LC) via nucleus of solitary tract, which receives afferent vagal inputs. In rats, VNS elevates LC firing forebrain noradrenaline levels, whereas lesions suppress efficacy. Noninvasive transcutaneous (tVNS) uses electrical that targets auricular branch vagus at cymba conchae ear. However, extent tVNS mimics remains unclear. Here, we investigated short-term in healthy human male volunteers ( n = 24), using high-density EEG pupillometry during visual fixation rest. We compared short (3.4 s) trials sham earlobe (far from branch) control for somatosensory stimulation. Although did differ subjective intensity ratings, led robust pupil dilation (peaking 4–5 s after trial onset) was significantly higher than following further quantified, parallel factor analysis, how modulates idle occipital alpha (8–13Hz) activity identified each participant. found greater attenuation oscillations by This demonstrates reliably induces pupillary markers arousal beyond stimulation, thus supporting hypothesis other arousal-promoting neuromodulatory signaling, invasive VNS. SIGNIFICANCE STATEMENT Current noninvasive brain techniques mostly confined modulating cortical activity, as typical with transcranial magnetic or direct/alternating current Transcutaneous has been proposed stimulate subcortical nuclei, though previous studies yielded inconsistent results. Here show pulses naive induced transient oscillations. These line established on coeruleus–noradrenaline support Therefore, can be a tool studying endogenous signaling affects cognition, including perception, attention, memory, decision-making; also developing novel clinical applications.

Язык: Английский

Процитировано

152
The Locus Coeruleus- Norepinephrine System in Stress and Arousal: Unraveling Historical, Current, and Future Perspectives DOI Creative Commons
Jennifer A. Ross, Elisabeth J. Van Bockstaele

Frontiers in Psychiatry, Год журнала: 2021, Номер 11

Опубликована: Янв. 27, 2021

Arousal may be understood on a spectrum, with excessive sleepiness, cognitive dysfunction, and inattention one side, wakeful state in the middle, hypervigilance, panic, psychosis other side. However, historically, concepts of arousal stress have been challenging to define as measurable experimental variables. Divergent efforts study these subjects given rise several disciplines, including neurobiology, neuroendocrinology, neuroscience. We discuss technological advancements that chronologically led our current understanding system, focusing multifaceted nucleus locus coeruleus. share contemporary perspective hypotheses others context capabilities future developments will required move forward this area research.

Язык: Английский

Процитировано

146
Vagus nerve stimulation induces widespread cortical and behavioral activation DOI Creative Commons
Lindsay Collins, Laura Boddington,

Paul J. Steffan

и другие.

Current Biology, Год журнала: 2021, Номер 31(10), С. 2088 - 2098.e3

Опубликована: Март 19, 2021

Язык: Английский

Процитировано

111
Noradrenergic modulation of rhythmic neural activity shapes selective attention DOI
Martin J. Dahl, Mara Mather, Markus Werkle‐Bergner

и другие.

Trends in Cognitive Sciences, Год журнала: 2021, Номер 26(1), С. 38 - 52

Опубликована: Ноя. 16, 2021

Язык: Английский

Процитировано

107
Coupling of pupil- and neuronal population dynamics reveals diverse influences of arousal on cortical processing DOI Creative Commons
Thomas Pfeffer, Christian Keitel, Daniel S. Kluger

и другие.

eLife, Год журнала: 2022, Номер 11

Опубликована: Фев. 8, 2022

Fluctuations in arousal, controlled by subcortical neuromodulatory systems, continuously shape cortical state, with profound consequences for information processing. Yet, how arousal signals influence population activity detail has so far only been characterized a few selected brain regions. Traditional accounts conceptualize as homogeneous modulator of neural across the cerebral cortex. Recent insights, however, point to higher specificity effects on different components and Here, we provide comprehensive account relationships between fluctuations neuronal human brain. Exploiting established link pupil size central performed concurrent magnetoencephalographic (MEG) pupillographic recordings large number participants, pooled three laboratories. We found cascade relative peak timing spontaneous dilations: Decreases low-frequency (2–8 Hz) temporal lateral frontal cortex, followed increased high-frequency (>64 mid-frontal regions, monotonic inverted U intermediate frequency-range (8–32 occipito-parietal Pupil-linked also coincided widespread changes structure aperiodic component activity, indicative excitation-inhibition balance underlying microcircuits. Our results novel basis studying modulation cognitive computations circuits.

Язык: Английский

Процитировано

72
Beyond task response—Pre-stimulus activity modulates contents of consciousness DOI
Georg Northoff, Federico Zilio, Jianfeng Zhang

и другие.

Physics of Life Reviews, Год журнала: 2024, Номер 49, С. 19 - 37

Опубликована: Март 4, 2024

Язык: Английский

Процитировано

22
A disinhibitory circuit mechanism explains a general principle of peak performance during mid-level arousal DOI Creative Commons
Lola Beerendonk, Jorge F. Mejías, Stijn A. Nuiten

и другие.

Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(5)

Опубликована: Янв. 26, 2024

Perceptual decision-making is highly dependent on the momentary arousal state of brain, which fluctuates over time a scale hours, minutes, and even seconds. The textbook relationship between task performance captured by an inverted U-shape, as put forward in Yerkes–Dodson law. This law suggests optimal at moderate levels impaired low or high levels. However, despite its popularity, evidence for this humans mixed best. Here, we use pupil-indexed data from various perceptual tasks to provide converging U-shaped spontaneous fluctuations across different decision types (discrimination, detection) sensory modalities (visual, auditory). To further understand relationship, built neurobiologically plausible mechanistic model show that it possible reproduce our findings incorporating two interneurons are both modulated signal. architecture produces dynamical regimes under influence arousal: one regime increases with another decreases arousal, together forming arousal–performance relationship. We conclude general robust property processing. It might be brought about act disinhibitory pathway neural populations encode available used decision.

Язык: Английский

Процитировано

21