Predictive neural computations in the cerebellum contribute to motor planning and faster behavioral responses in larval zebrafish

Science Advances, Год журнала: 2024, Номер 10(1)

Опубликована: Янв. 3, 2024

The ability to predict the future based on past experience lies at core of brain's adapt behavior. However, neural mechanisms that participate in generating and updating predictions are not clearly understood. Further, evolutionary antecedents prevalence predictive processing among vertebrates even less explored. Here, we show evidence via involvement cerebellar circuits larval zebrafish. We presented stereotyped optic flow stimuli zebrafish evoke swims discovered lesioning cerebellum abolished prediction-dependent modulation swim latency. When expectations direction did match with reality, error signals arrive Purkinje cells olivary climbing fibers, whereas granule encode expectation. Strong representations expectation correlate faster responses vice versa. In sum, our results for nonmammalian cerebellum, an evolutionarily conserved brain structure.

Язык: Английский

---

Consensus Paper: Cerebellum and Reward

The Cerebellum, Год журнала: 2024, Номер 23(5), С. 2169 - 2192

Опубликована: Май 20, 2024

Язык: Английский

---

Reward signals in the motor cortex: from biology to neurotechnology

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Фев. 3, 2025

Over the past decade, research has shown that primary motor cortex (M1), brain's main output for movement, also responds to rewards. These reward signals may shape in its final stages, influencing movement invigoration and learning. In this Perspective, we highlight functional roles of M1 propose how they could guide advances neurotechnologies restoration, specifically brain-computer interfaces non-invasive brain stimulation. Understanding open new avenues enhancing control rehabilitation. The (M1) not only drives but authors discuss M1's transform like stimulation recovery.

Язык: Английский

---

Adaptive Prediction for Social Contexts: The Cerebellar Contribution to Typical and Atypical Social Behaviors

Annual Review of Neuroscience, Год журнала: 2021, Номер 44(1), С. 475 - 493

Опубликована: Июль 8, 2021

Social interactions involve processes ranging from face recognition to understanding others’ intentions. To guide appropriate behavior in a given context, social rely on accurately predicting the outcomes of one's actions and thoughts others. Because are inherently dynamic, these predictions must be continuously adapted. The neural correlates processing have largely focused emotion, mentalizing, reward networks, without integration systems involved prediction. cerebellum forms predictive models calibrate movements adapt them changing situations, cerebellar modeling is thought extend nonmotor behaviors. Primary dysfunction can produce deficits, atypical structure function reported autism, which characterized by communication challenges processing. We examine evidence that cerebellar-mediated adaptation play important roles argue disruptions contribute autism.

Язык: Английский

---

New Horizons on Non-invasive Brain Stimulation of the Social and Affective Cerebellum

The Cerebellum, Год журнала: 2021, Номер 21(3), С. 482 - 496

Опубликована: Июль 16, 2021

Язык: Английский

---

Maturation of Purkinje cell firing properties relies on neurogenesis of excitatory neurons

eLife, Год журнала: 2021, Номер 10

Опубликована: Сен. 20, 2021

Preterm infants that suffer cerebellar insults often develop motor disorders and cognitive difficulty. Excitatory granule cells, the most numerous neuron type in brain, are especially vulnerable likely instigate disease by impairing function of their targets, Purkinje cells. Here, we use regional genetic manipulations vivo electrophysiology to test whether excitatory neurons establish firing properties cells during postnatal mouse development. We generated mutant mice lack majority tracked structural functional consequences on reveal fail acquire typical morphology connectivity, concomitant transformation cell activity does not occur either. also show our pups have impaired behaviors vocal skills. These data argue define maturation time-window for functions refine cerebellar-dependent behaviors.

Язык: Английский

---

The cerebellum contributes to context-effects during fear extinction learning: A 7T fMRI study

NeuroImage, Год журнала: 2022, Номер 253, С. 119080 - 119080

Опубликована: Март 9, 2022

The cerebellum is involved in the acquisition and consolidation of learned fear responses. Knowledge about its contribution to extinction learning, however, sparse. Extinction processes likely involve erasure memories, but there ample evidence that at least part original memory remains. We asked question whether persists within following training. renewal effect, reoccurrence extinguished during recall a context different from context, constitutes one phenomena indicating responses not fully erased performed differential AB-A/B conditioning paradigm 7-Tesla (7T) MRI system 31 young healthy men. On day 1, training was A B. 2, tested contexts As expected, participants predict CS+ followed by an aversive electric shock Skin conductance (SCRs) were significantly higher compared CS- end acquisition. Differences SCRs vanished reoccurred renewal. Fitting SCR data, deep neural network model trained correct value for given stimulus context. Event-related fMRI analysis with model-derived prediction values as parametric modulations showed significant effects on activation posterolateral (lobules VI Crus I) recall. Since differ based (CS+ CS-) recall, data provide support context-related associations. Likewise, mean β highest lobules I bilaterally related early similar pattern seen vermis, only trend level. Thus, remains found cerebellar activations which reflect associative non-associative aspects task. Cerebellar activations, CS-. never shock, may contribute learning CS, example safety cue.

Язык: Английский

---

Cerebellum encodes and influences the initiation, performance, and termination of discontinuous movements in mice

eLife, Год журнала: 2022, Номер 11

Опубликована: Апрель 22, 2022

The cerebellum is hypothesized to represent timing information important for organizing salient motor events during periodically performed discontinuous movements. To provide functional evidence validating this idea, we measured and manipulated Purkinje cell (PC) activity in the lateral of mice trained volitionally perform periodic bouts licking regularly allocated water rewards. Overall, PC simple spiking modulated task performance, mapping phasic tongue protrusions retractions, as well ramping prior both lick-bout initiation termination, two delimiting movement cycles. onset occurred earlier uncued exploratory that anticipated availability relative was reactive allocation, suggesting engaged differently depending on context. In a subpopulation PCs, climbing-fiber-evoked responses also increased initiation, but not highlighting differences how cerebellar input pathways task-related information. Optogenetic perturbation disrupted behavior by degrading rhythmicity addition initiating terminating confirming causative role organization. Together, these results substantiate contributes repeated actions.

Язык: Английский

---

Purkinje cell dopaminergic inputs to astrocytes regulate cerebellar-dependent behavior

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Март 23, 2023

Abstract Dopamine has a significant role in motor and cognitive function. The dopaminergic pathways originating from the midbrain have received most attention; however, relevance of cerebellar system is largely undiscovered. Here, we show that major astrocyte type Bergmann glial cells express D1 receptors. can be synthesized Purkinje by cytochrome P450 released an activity-dependent fashion. We demonstrate activation receptors induces membrane depolarization Ca 2+ release internal store. These astrocytic activities turn modify cell output altering its excitatory inhibitory synaptic input. Lastly, conditional knockout results decreased locomotor activity impaired social activity. contribute to understanding molecular, cellular, circuit mechanisms underlying dopamine function cerebellum, revealing critical for behavior.

Язык: Английский

---

A cerebellar granule cell-climbing fiber computation to learn to track long time intervals

Neuron, Год журнала: 2024, Номер 112(16), С. 2749 - 2764.e7

Опубликована: Июнь 12, 2024

In classical cerebellar learning, Purkinje cells (PkCs) associate climbing fiber (CF) error signals with predictive granule (GrCs) that were active just prior (∼150 ms). The cerebellum also contributes to behaviors characterized by longer timescales. To investigate how GrC-CF-PkC circuits might learn seconds-long predictions, we imaged simultaneous GrC-CF activity over days of forelimb operant conditioning for delayed water reward. As mice learned reward timing, numerous GrCs developed anticipatory ramping at different rates until delivery, followed widespread time-locked CF spiking. Relearning delays further lengthened GrC activations. We computed CF-dependent GrC→PkC plasticity rules, demonstrating reward-evoked spikes sufficed grade many synapses timing. predicted and confirmed PkCs could thereby continuously ramp across intervals from movement Learning thus leads new temporal bases linking predictors remote signals—a strategy well suited learning track the long common in cognitive domains.

Язык: Английский

---