Identification and organization of a postural anti-gravity module in the cerebellar vermis DOI Creative Commons

Aurélien Gouhier,

Vincent Villette,

Benjamin Mathieu

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Окт. 10, 2023

ABSTRACT The cerebellum is known to control the proper balance of isometric muscular contractions that maintain body posture. Current optogenetic manipulations cerebellar cortex output, however, have focused on ballistic movements, examining movement initiation or perturbations. Here, by stimulations Purkinje cells, output cortex, we evaluate posture maintenance. By sequential analysis movement, dissect effect stimulation into a directly induced then followed compensatory reflex regain We identify module in medial part anterior vermis which, through multiple muscle tone regulation, involved postural anti-gravity maintenance body. Moreover, report an antero-posterior and medio-lateral functional segregation over vermal lobules IV/V/VI. Taken together our results open new avenues for better understanding modular organization its role Highlights Vermal cell activation elicits graded collapse standing mouse triggers secondary composite An identified function somatotopically organized within this

Язык: Английский

Specialized connectivity of molecular layer interneuron subtypes leads to disinhibition and synchronous inhibition of cerebellar Purkinje cells DOI

Elizabeth P. Lackey,

Luis Moreira,

Aliya Norton

и другие.

Neuron, Год журнала: 2024, Номер 112(14), С. 2333 - 2348.e6

Опубликована: Апрель 30, 2024

Язык: Английский

Процитировано

21
Cerebellar associative learning underlies skilled reach adaptation DOI
Dylan Calame,

Matthew I. Becker,

Abigail L. Person

и другие.

Nature Neuroscience, Год журнала: 2023, Номер 26(6), С. 1068 - 1079

Опубликована: Май 29, 2023

Язык: Английский

Процитировано

33
Activity map of a cortico-cerebellar loop underlying motor planning DOI Creative Commons
Jia Zhu,

Hana Hasanbegović,

Liu D. Liu

и другие.

Nature Neuroscience, Год журнала: 2023, Номер 26(11), С. 1916 - 1928

Опубликована: Окт. 9, 2023

The neocortex and cerebellum interact to mediate cognitive functions. It remains unknown how the two structures organize into functional networks specific behaviors. Here we delineate activity supporting motor planning in relation mesoscale cortico-cerebellar connectome. In mice directional licking based on short-term memory, preparatory instructing future movement depends anterior lateral cortex (ALM) cerebellum. Transneuronal tracing revealed divergent largely open-loop connectivity between ALM distributed regions of A cerebellum-wide survey neuronal enriched hotspot with conjunctive input-output ALM. Perturbation experiments show that conjunction were required for maintaining correct subsequent movement. Other cerebellar contributed little despite input or output These results identify a loop suggest selectively establishes reciprocal communications orchestrate planning.

Язык: Английский

Процитировано

29
Impaired cerebellar plasticity hypersensitizes sensory reflexes in SCN2A-associated ASD DOI Creative Commons
Chenyu Wang, Kimberly D. Derderian,

Elizabeth Hamada

и другие.

Neuron, Год журнала: 2024, Номер 112(9), С. 1444 - 1455.e5

Опубликована: Фев. 26, 2024

Children diagnosed with autism spectrum disorder (ASD) commonly present sensory hypersensitivity or abnormally strong reactions to stimuli. Such can be overwhelming, causing high levels of distress that contribute markedly the negative aspects disorder. Here, we identify a mechanism underlies in sensorimotor reflex found altered humans and mice loss function ASD risk-factor gene SCN2A. The cerebellum-dependent vestibulo-ocular (VOR), which helps maintain one's gaze during movement, was hypersensitized due deficits cerebellar synaptic plasticity. Heterozygous SCN2A-encoded Na

Язык: Английский

Процитировано

13
Cerebellar control of targeted tongue movements DOI Creative Commons
Lorenzo Bina,

Camilla Ciapponi,

Si‐yang Yu

и другие.

The Journal of Physiology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 26, 2025

Abstract The cerebellum is critical for coordinating movements related to eating, drinking and swallowing, all of which require proper control the tongue. Cerebellar Purkinje cells can encode tongue movements, but it unclear how their simple spikes complex induce changes in shape that contribute goal‐directed movements. To study these relations, we recorded stimulated vermis hemispheres mice during spontaneous licking from a stationary or moving water spout. We found rhythmic with both spikes. Increased spike firing protrusion induces ipsiversive bending Unexpected target location trigger alter subsequent licks, adjusting trajectory. Furthermore, observed increased behavioural state at start end bouts. Using machine learning, confirmed alterations cell activity accompany licking, different often exerting heterogeneous encoding schemes. Our data highlight directional movement paramount cerebellar function modulation are complementary acquisition execution sensorimotor coordination. These results bring us closer understanding clinical implications disorders swallowing. image Key points When drinking, make directed towards source. fire rhythmically tune position source affects direction report also adjust right direction.

Язык: Английский

Процитировано

1
Engaging distributed cortical and cerebellar networks through motor execution, observation, and imagery DOI Creative Commons
Julia U. Henschke, Janelle M.P. Pakan

Frontiers in Systems Neuroscience, Год журнала: 2023, Номер 17

Опубликована: Апрель 11, 2023

When we interact with the environment around us, are sometimes active participants, making directed physical motor movements and other times only mentally engaging our environment, taking in sensory information internally planning next move without movement. Traditionally, cortical regions key subcortical structures such as cerebellum have been tightly linked to initiation, coordination, behavior. However, recent neuroimaging studies noted activation of wider networks specifically during various forms processing, including observations actions mental rehearsal through imagery. This phenomenon cognitive engagement traditional raises question how these brain involved initiation movement output. Here, will review evidence for distributed network execution, observation, imagery human well potential cerebellar involvement motor-related cognition. Converging suggests that a common global is both execution observation or imagery, specific task-dependent shifts patterns. We further discuss underlying cross-species anatomical support functions role cerebrocerebellar communication action

Язык: Английский

Процитировано

23
A cerebellar granule cell-climbing fiber computation to learn to track long time intervals DOI Creative Commons
Martha G. Garcia-Garcia,

Akash Kapoor,

Oluwatobi Akinwale

и другие.

Neuron, Год журнала: 2024, Номер 112(16), С. 2749 - 2764.e7

Опубликована: Июнь 12, 2024

In classical cerebellar learning, Purkinje cells (PkCs) associate climbing fiber (CF) error signals with predictive granule (GrCs) that were active just prior (∼150 ms). The cerebellum also contributes to behaviors characterized by longer timescales. To investigate how GrC-CF-PkC circuits might learn seconds-long predictions, we imaged simultaneous GrC-CF activity over days of forelimb operant conditioning for delayed water reward. As mice learned reward timing, numerous GrCs developed anticipatory ramping at different rates until delivery, followed widespread time-locked CF spiking. Relearning delays further lengthened GrC activations. We computed CF-dependent GrC→PkC plasticity rules, demonstrating reward-evoked spikes sufficed grade many synapses timing. predicted and confirmed PkCs could thereby continuously ramp across intervals from movement Learning thus leads new temporal bases linking predictors remote signals—a strategy well suited learning track the long common in cognitive domains.

Язык: Английский

Процитировано

9
Diversity of the nature of input and output signals in the cerebellum suggests a diversity of function DOI
Jean‐Jacques Orban de Xivry, Jörn Diedrichsen

Current Opinion in Behavioral Sciences, Год журнала: 2024, Номер 57, С. 101386 - 101386

Опубликована: Апрель 21, 2024

Язык: Английский

Процитировано

6
Libet’s legacy: A primer to the neuroscience of volition DOI
Tomáš Dominik, Alfred R. Mele, Aaron Schurger

и другие.

Neuroscience & Biobehavioral Reviews, Год журнала: 2023, Номер 157, С. 105503 - 105503

Опубликована: Дек. 9, 2023

Язык: Английский

Процитировано

11
Mechanisms and Consequences of Cerebellar Purkinje Cell Disinhibition in a Mouse Model of Duchenne Muscular Dystrophy DOI Creative Commons
Wan‐Chen Wu,

Samual P. Bradley,

Jason M. Christie

и другие.

Journal of Neuroscience, Год журнала: 2022, Номер 42(10), С. 2103 - 2115

Опубликована: Янв. 21, 2022

Duchenne muscular dystrophy (DMD), the most common form of childhood dystrophy, is caused by mutations in dystrophin gene. In addition to debilitating muscle degeneration, patients display a range cognitive deficits thought result from loss normally expressed brain. While function tissue well characterized, its role brain still poorly understood. The highest expression mouse cerebellar Purkinje cells (PCs), where it colocalizes with GABA A receptor clusters. Using ex vivo electrophysiological recordings connected molecular layer interneuron (MLI)–PC pairs, we investigated changes inhibitory synaptic transmission deficiency. male mdx mice (which lack long-form dystrophin), found that responses at MLI–PC pairs were reduced ∼60% because both decreased quantal response amplitude and number functional vesicle release sites. electron microscopy, significantly fewer smaller anatomically defined synapses contacting soma PCs mice, suggesting may play critical synapse formation and/or maintenance. Functionally, MLI-evoked pauses PC firing acute slices. awake showed increased sensory-evoked simple spike positively modulating PCs, consistent feedforward inhibition, but no change negatively PCs. These data suggest deficiency disrupts signaling circuit patterns, potentially contributing motor observed DMD patients. SIGNIFICANCE STATEMENT (DMD) primarily characterized progressive weakening genetic gene for dystrophin. Dystrophin also CNS, experience nonprogressive deficits. pathophysiology CNS neurons resulting are as model, specifically strength connections, participates maintenance these synapses. This work provides insight into establishes neuronal dysfunction, which underlie DMD.

Язык: Английский

Процитировано

16