Brain Behavior and Immunity,
Год журнала:
2022,
Номер
104, С. 97 - 109
Опубликована: Июнь 1, 2022
Exposure
to
chronic
adverse
conditions,
and
the
resultant
activation
of
neurobiological
response
cascade,
has
been
associated
with
an
increased
risk
early
onset
age-related
disease
and,
recently,
older
biological
age.
This
body
research
led
hypothesis
that
exposure
stressful
life
experiences,
when
occurring
repeatedly
or
over
a
prolonged
period,
may
accelerate
rate
at
which
ages.
The
mechanisms
through
psychosocial
stress
influences
distinct
aging
pathways
alter
rates
likely
involve
multiple
layers
in
physiological-molecular
network.
In
this
review,
we
integrate
using
animal,
human,
vitro
models
begin
delineate
impact
aging,
as
well
neuroendocrine
mediators
(i.e.,
norepinephrine,
epinephrine,
glucocorticoids)
drive
these
effects.
Findings
highlight
key
connections
between
namely
cellular
metabolic
activity,
DNA
damage,
telomere
length,
senescence,
inflammatory
patterns.
We
conclude
guiding
framework
conceptual
model
outlines
most
promising
by
conditions
could
point
missing
gaps
knowledge
where
future
best
answer
pressing
questions.
Signal Transduction and Targeted Therapy,
Год журнала:
2022,
Номер
7(1)
Опубликована: Дек. 16, 2022
Aging
is
a
gradual
and
irreversible
pathophysiological
process.
It
presents
with
declines
in
tissue
cell
functions
significant
increases
the
risks
of
various
aging-related
diseases,
including
neurodegenerative
cardiovascular
metabolic
musculoskeletal
immune
system
diseases.
Although
development
modern
medicine
has
promoted
human
health
greatly
extended
life
expectancy,
aging
society,
variety
chronic
diseases
have
gradually
become
most
important
causes
disability
death
elderly
individuals.
Current
research
on
focuses
elucidating
how
endogenous
exogenous
stresses
(such
as
genomic
instability,
telomere
dysfunction,
epigenetic
alterations,
loss
proteostasis,
compromise
autophagy,
mitochondrial
cellular
senescence,
stem
exhaustion,
altered
intercellular
communication,
deregulated
nutrient
sensing)
participate
regulation
aging.
Furthermore,
thorough
pathogenesis
to
identify
interventions
that
promote
longevity
caloric
restriction,
microbiota
transplantation,
nutritional
intervention)
clinical
treatment
methods
for
(depletion
senescent
cells,
therapy,
antioxidative
anti-inflammatory
treatments,
hormone
replacement
therapy)
could
decrease
incidence
turn
healthy
longevity.
Measures
to
quantify
changes
in
the
pace
of
biological
aging
response
intervention
are
needed
evaluate
geroprotective
interventions
for
humans.
Previously,
we
showed
that
quantification
from
a
DNA-methylation
blood
test
was
possible
(Belsky
et
al.,
2020).
Here,
report
next-generation
biomarker
Pace
Aging,
DunedinPACE
(for
Aging
Calculated
Epigenome).
Biological
aging
is
the
gradual,
progressive
decline
in
system
integrity
that
occurs
with
advancing
chronological
age,
causing
morbidity
and
disability.
Measurements
of
pace
are
needed
as
surrogate
endpoints
trials
therapies
designed
to
prevent
disease
by
slowing
biological
aging.
We
report
a
blood-DNA-methylation
measure
sensitive
variation
among
individuals
born
same
year.
first
modeled
change-over-time
18
biomarkers
tracking
organ-system
across
12
years
follow-up
n
=
954
members
Dunedin
Study
1972–1973.
Rates
change
each
biomarker
over
ages
26–38
were
composited
form
aging-related
decline,
termed
Pace-of-Aging.
Elastic-net
regression
was
used
develop
DNA-methylation
predictor
Pace-of-Aging,
called
DunedinPoAm
for
Dunedin(P)ace(o)f(A)ging(m)ethylation.
Validation
analysis
cohort
studies
CALERIE
trial
provide
proof-of-principle
single-time-point
person’s
Cell,
Год журнала:
2022,
Номер
185(9), С. 1455 - 1470
Опубликована: Апрель 1, 2022
Diet
as
a
whole,
encompassing
food
composition,
calorie
intake,
and
the
length
frequency
of
fasting
periods,
affects
time
span
in
which
health
functional
capacity
are
maintained.
Here,
we
analyze
aging
nutrition
studies
simple
organisms,
rodents,
monkeys,
humans
to
link
longevity
conserved
growth
metabolic
pathways
outline
their
role
age-related
disease.
We
focus
on
feasible
nutritional
strategies
shown
delay
and/or
prevent
diseases
through
epidemiological,
model
organism,
clinical,
centenarian
underline
need
avoid
malnourishment
frailty.
These
findings
integrated
define
diet
based
multi-pillar
approach
adjusted
for
age
status
optimize
lifespan
healthspan
humans.
Clinical Epigenetics,
Год журнала:
2020,
Номер
12(1)
Опубликована: Июль 31, 2020
Abstract
Background
Individuals
of
the
same
chronological
age
display
different
rates
biological
ageing.
A
number
measures
have
been
proposed
which
harness
age-related
changes
in
DNA
methylation
profiles.
These
include
five
‘epigenetic
clocks’
provide
an
index
how
much
individual’s
differs
from
their
at
time
measurement.
The
clocks
encompass
methylation-based
predictors
(HorvathAge,
HannumAge),
all-cause
mortality
(DNAm
PhenoAge,
DNAm
GrimAge)
and
telomere
length
Telomere
Length).
sixth
epigenetic
measure
ageing
these
that
it
acts
as
a
speedometer
providing
single
time-point
measurement
pace
This
is
termed
DunedinPoAm.
In
this
study,
we
test
association
between
six
prevalence
incidence
leading
causes
disease
burden
high-income
countries
(
n
≤
9537,
Generation
Scotland:
Scottish
Family
Health
Study).
Results
GrimAge
predicted
clinically
diagnosed
chronic
obstructive
pulmonary
(COPD),
type
2
diabetes
ischemic
heart
after
13
years
follow-up
(hazard
ratios
=
2.22,
1.52
1.41,
respectively).
DunedinPoAm
COPD
lung
cancer
2.02
1.45,
PhenoAge
ratio
1.54).
Length
associated
with
0.80).
mortality,
spirometry
study
baseline.
associations
were
present
adjusting
for
possible
confounding
risk
factors
including
alcohol
consumption,
body
mass
index,
deprivation,
education
tobacco
smoking
surpassed
stringent
Bonferroni-corrected
significance
thresholds.
Conclusions
Our
data
suggest
may
utility
clinical
settings
to
complement
gold-standard
methods
assessment
management.
The Journals of Gerontology Series A,
Год журнала:
2021,
Номер
76(6), С. 1117 - 1123
Опубликована: Янв. 16, 2021
Abstract
Background
Many
DNA
methylation-based
indicators
have
been
developed
as
summary
measures
of
epigenetic
aging.
We
examine
the
associations
between
13
clocks,
including
4
second
generation
well
links
clocks
to
social,
demographic,
and
behavioral
factors
known
be
related
health
outcomes:
sex,
race/ethnicity,
socioeconomic
status,
obesity,
lifetime
smoking
pack-years.
Methods
The
Health
Retirement
Study
is
data
source
which
a
nationally
representative
sample
Americans
over
age
50.
Assessment
methylation
was
based
on
EPIC
chip
were
existing
literature.
Results
vary
in
strength
their
relationships
with
age,
each
other
independent
variables.
Second
trained
health-related
characteristics
tend
relate
more
strongly
sociodemographic
behaviors
associated
outcomes
this
group.
Conclusions
Users
publicly
available
set
should
aware
that
variables
process
change
age.
