Prefrontal Cortex Development in Health and Disease: Lessons from Rodents and Humans

Trends in Neurosciences, Год журнала: 2020, Номер 44(3), С. 227 - 240

Опубликована: Ноя. 24, 2020

The role of the prefrontal cortex (PFC) takes center stage among unanswered questions in modern neuroscience. PFC has a Janus-faced nature: it enables sophisticated cognitive and social abilities that reach their maximum expression humans, yet underlies some devastating symptoms psychiatric disorders. Accordingly, appropriate development is crucial for many high-order dysregulation this process been linked to various neuropsychiatric diseases. Reviewing recent advances field, with primary focus on rodents we highlight why, despite differences across species, cross-species approach fruitful strategy understanding development. We briefly review developmental contribution molecules extensively discuss how electrical activity controls early maturation wiring areas, as well emergence refinement input-output circuitry involved processing. Finally, mechanisms dysfunction relevance

Язык: Английский

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An increase of inhibition drives the developmental decorrelation of neural activity

eLife, Год журнала: 2022, Номер 11

Опубликована: Авг. 17, 2022

Throughout development, the brain transits from early highly synchronous activity patterns to a mature state with sparse and decorrelated neural activity, yet mechanisms underlying this process are poorly understood. The developmental transition has important functional consequences, as latter is thought allow for more efficient storage, retrieval, processing of information. Here, we show that, in mouse medial prefrontal cortex (mPFC), during first two postnatal weeks decorrelates following specific spatial patterns. This accompanied by concomitant tilting excitation-inhibition (E-I) ratio toward inhibition. Using optogenetic manipulations network modeling, that phenomena mechanistically linked, relative increase inhibition drives decorrelation activity. Accordingly, mice mimicking etiology neurodevelopmental disorders, subtle alterations E-I associated impairments correlational structure spike trains. Finally, capitalizing on EEG data newborn babies, an analogous takes place also human brain. Thus, changes control (de)correlation and, these means, its imbalance might contribute pathogenesis disorders.

Язык: Английский

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Impact of Perineuronal Nets on Electrophysiology of Parvalbumin Interneurons, Principal Neurons, and Brain Oscillations: A Review

Frontiers in Synaptic Neuroscience, Год журнала: 2021, Номер 13

Опубликована: Май 10, 2021

Perineuronal nets (PNNs) are specialized extracellular matrix structures that surround specific neurons in the brain and spinal cord, appear during critical periods of development, restrict plasticity adulthood. Removal PNNs can reinstate juvenile-like or, cases PNN removal early developmental stages, extends period. mainly parvalbumin (PV)-containing, fast-spiking GABAergic interneurons several regions. These inhibitory profoundly inhibit network surrounding via their elaborate contacts with local pyramidal neurons, they key contributors to gamma oscillations generated across Among other functions, these regulate associated learning, decision making, attention, cognitive flexibility, working memory. The detailed mechanisms by which increases only beginning be understood. Here, we review impact on electrophysiological features underlying PV nearby including changes intrinsic synaptic membrane properties, oscillations, how may alter integration memory-related information. Additionally, affects plasticity-associated phenomena such as long-term potentiation (LTP), depression (LTD), paired-pulse ratio (PPR). results discussed context role circuit function alters this function.

Язык: Английский

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A transient developmental increase in prefrontal activity alters network maturation and causes cognitive dysfunction in adult mice

Neuron, Год журнала: 2021, Номер 109(8), С. 1350 - 1364.e6

Опубликована: Март 7, 2021

Disturbed neuronal activity in neuropsychiatric pathologies emerges during development and might cause multifold dysfunction by interfering with apoptosis, dendritic growth, synapse formation. However, how altered electrical early life affects function behavior adults is unknown. Here, we address this question transiently increasing the coordinated of layer 2/3 pyramidal neurons medial prefrontal cortex neonatal mice monitoring long-term functional behavioral consequences. We show that increased causes premature maturation interneuronal density. Consequently, inhibitory feedback fast-spiking interneurons excitation/inhibition imbalance circuits young result weaker evoked synchronization gamma frequency. These structural changes ultimately lead to poorer mnemonic social abilities. Thus, actively controls cognitive performance be critical for symptoms diseases.

Язык: Английский

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Adolescent thalamic inhibition leads to long-lasting impairments in prefrontal cortex function

Nature Neuroscience, Год журнала: 2022, Номер 25(6), С. 714 - 725

Опубликована: Май 19, 2022

Язык: Английский

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Network state transitions during cortical development

Nature reviews. Neuroscience, Год журнала: 2024, Номер 25(8), С. 535 - 552

Опубликована: Май 23, 2024

Язык: Английский

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Episodic memory development: Bridging animal and human research

Neuron, Год журнала: 2024, Номер 112(7), С. 1060 - 1080

Опубликована: Фев. 14, 2024

Human episodic memory is not functionally evident until about 2 years of age and continues to develop into the school years. Behavioral studies have elucidated this developmental timeline its constituent processes. In tandem, lesion neurophysiological in non-human primates rodents identified key neural substrates circuit mechanisms that may underlie development. Despite progress, collaborative efforts between psychologists neuroscientists remain limited, hindering progress. Here, we seek bridge human development research by offering a comparative review using humans, primates, rodents. We highlight critical theoretical methodological issues limit cross-fertilization propose common framework, adaptable different species, facilitate cross-species endeavors.

Язык: Английский

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Gamma activity accelerates during prefrontal development

eLife, Год журнала: 2020, Номер 9

Опубликована: Ноя. 18, 2020

Gamma oscillations are a prominent activity pattern in the cerebral cortex. While gamma rhythms have been extensively studied adult prefrontal cortex context of cognitive (dys)functions, little is known about their development. We addressed this issue by using extracellular recordings and optogenetic stimulations mice across postnatal show that fast rhythmic becomes during second week. initially at 15 Hz, oscillatory progressively accelerates with age stabilizes within frequency range (30-80 Hz) fourth Activation layer 2/3 pyramidal neurons drives throughout development, yet acceleration follows similar temporal dynamics as maturation fast-spiking interneurons. These findings uncover development provide framework to examine origin abnormal neurodevelopmental disorders.

Язык: Английский

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Mature parvalbumin interneuron function in prefrontal cortex requires activity during a postnatal sensitive period

eLife, Год журнала: 2022, Номер 11

Опубликована: Дек. 28, 2022

In their seminal findings, Hubel and Wiesel identified sensitive periods in which experience can exert lasting effects on adult visual cortical functioning behavior via transient changes neuronal activity during development. Whether comparable exist for non-sensory cortices, such as the prefrontal cortex, alterations determine circuit function is still an active area of research. Here, using mice we demonstrate that inhibition parvalbumin (PV)-expressing interneurons juvenile adolescent period, results persistent impairments connectivity, vivo network function, behavioral flexibility be reversed by targeted activation PV adulthood. contrast, reversible suppression interneuron adulthood produces no effects. These findings identify activity-dependent period maturation highlight how abnormal development alters cognitive behavior.

Язык: Английский

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Gabaergic Interneurons in Early Brain Development: Conducting and Orchestrated by Cortical Network Activity

Frontiers in Molecular Neuroscience, Год журнала: 2022, Номер 14

Опубликована: Янв. 3, 2022

Throughout early phases of brain development, the two main neural signaling mechanisms-excitation and inhibition-are dynamically sculpted in neocortex to establish primary functions. Despite its relatively late formation persistent developmental changes, GABAergic system promotes ordered shaping neuronal circuits at structural functional levels. Within this frame, interneurons participate first spontaneous later sensory-evoked activity patterns that precede cortical functions mature brain. Upon their subcortical generation, embryonic must orderly migrate settle respective target layers before they can actively engage network activity. During process, changes molecular synaptic level allow not only coordinated but also pruning connections as well excitatory inhibitory synapses. At postsynaptic site, shift from an towards response is required enable synchronization within networks. Concomitantly, progressive specification different interneuron subtypes endows with distinct local region-specific modulation firing. Finally, apoptotic process further refines populations by constantly maintaining a controlled ratio neurons. Interestingly, many these fundamental complex processes are influenced-if directly controlled-by electrical Interneurons on subcellular, cellular, affected high frequency patterns, such spindle burst gamma oscillations rodents delta brushes humans. Conversely, maturation structure function each scales feeds back contributes generation essential for proper peri- postnatal development. Overall, more precise description conducting role terms how contribute specific patterns-as impinge orchestra members-will lead better understanding physiological pathophysiological development nervous system.

Язык: Английский

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