Identification of astroglia-like cardiac nexus glia that are critical regulators of cardiac development and function DOI Creative Commons

Nina L. Kikel-Coury,

Jacob P. Brandt, Isabel A. Correia

и другие.

PLoS Biology, Год журнала: 2021, Номер 19(11), С. e3001444 - e3001444

Опубликована: Ноя. 18, 2021

Glial cells are essential for functionality of the nervous system. Growing evidence underscores importance astrocytes; however, analogous astroglia in peripheral organs poorly understood. Using confocal time-lapse imaging, fate mapping, and mutant genesis a zebrafish model, we identify neural crest-derived glial cell, termed nexus glia, which utilizes Meteorin signaling via Jak/Stat3 to drive differentiation regulate heart rate rhythm. Nexus glia labeled with gfap, glast, glutamine synthetase, markers that typically denote cells. Further, analysis single-cell sequencing datasets human murine hearts across ages reveals astrocyte-like cells, confirm through multispecies approach. We show cardiac at outflow tract critical regulators both sympathetic parasympathetic These data establish crucial role on homeostasis provide description PNS.

Язык: Английский

Structure and Functions of the Vagus Nerve in Mammals DOI
Matteo Maria Ottaviani, Vaughan G. Macefield

Comprehensive physiology, Год журнала: 2022, Номер unknown, С. 3989 - 4037

Опубликована: Авг. 11, 2022

We review the structure and function of vagus nerve, drawing on information obtained in humans experimental animals. The nerve is largest longest cranial supplying structures neck, thorax, abdomen. It also only which vast majority its innervation territory resides outside head. While belonging to parasympathetic division autonomic nervous system, primarily sensory—it dominated by sensory axons. discuss macroscopic microscopic features including a detailed description extensive territory. Histochemical genetic profiles afferent efferent axons are detailed, as central nuclei involved processing conveyed generation motor (including parasympathetic) outflow via nerve. provide comprehensive physiological roles vagal neurons control cardiovascular, respiratory, gastrointestinal systems, finish with discussion interactions between immune system. © 2022 American Physiological Society. Compr Physiol 12: 3989–4037, 2022.

Язык: Английский

Процитировано

26
Functional anatomy of the vagus system: How does the polyvagal theory comply? DOI Creative Commons
Winfried Neuhuber, Hans‐Rudolf Berthoud

Biological Psychology, Год журнала: 2022, Номер 174, С. 108425 - 108425

Опубликована: Сен. 12, 2022

Язык: Английский

Процитировано

24
Cardiac vagal afferent neurotransmission in health and disease: review and knowledge gaps DOI Creative Commons
Valerie Y. H. van Weperen, Marmar Vaseghi

Frontiers in Neuroscience, Год журнала: 2023, Номер 17

Опубликована: Июнь 7, 2023

The meticulous control of cardiac sympathetic and parasympathetic tone regulates all facets function. This precise calibration efferent innervation is dependent on sensory information that relayed from the heart to central nervous system. vagus nerve, which contains vagal afferent fibers, carries brainstem. Vagal signaling has been predominantly shown increase response tone. However, appears change after injury, though much remains unknown. Even subsequent autonomic imbalance characterized by sympathoexcitation dysfunction, it unclear if, what extent, dysfunction involved in development withdrawal. review aims summarize current understanding under health setting cardiovascular disease, especially myocardial infarction, highlight knowledge gaps remain be addressed.

Язык: Английский

Процитировано

16
Respiratory sinus arrhythmia (RSA), vagal tone and biobehavioral integration: Beyond parasympathetic function DOI Creative Commons
Paul Grossman

Biological Psychology, Год журнала: 2023, Номер 186, С. 108739 - 108739

Опубликована: Дек. 25, 2023

Linchpin to the entire area of psychophysiological research and discussion vagus is respiratory cardiovascular phenomenon known as sinus arrhythmia (RSA; often synonymous with high-frequency heart-rate variability when it specifically linked frequency), i.e. rhythmic fluctuations in heart rate synchronized inspiration expiration. This article aims 1) clarify concepts, terms measures commonly employed during last half century scientific literature, which relate vagal function psychological processes general aspects health; 2) expand upon an earlier theoretical model, emphasizing importance RSA well beyond current focus parasympathetic mechanisms. A close examination its relations may dispel certain held beliefs about associations between functioning, nervous system (for nerve plays a major role), offer fresh perspectives likely functions adaptive significance RSA, RSA's relationship control. neither invariably reliable index cardiac tone nor central outflow heart. The model here presented posits that represents evolutionarily entrenched, significantly contributes meeting continuously changing metabolic, energy behavioral demands.

Язык: Английский

Процитировано

16
Analysis of Respiratory Sinus Arrhythmia and Directed Information Flow between Brain and Body Indicate Different Management Strategies of fMRI-Related Anxiety DOI Creative Commons
Beate Raßler, Katarzyna J. Blinowska, Maciej Kamínski

и другие.

Biomedicines, Год журнала: 2023, Номер 11(4), С. 1028 - 1028

Опубликована: Март 27, 2023

Respiratory sinus arrhythmia (RSA) denotes decrease of cardiac beat-to-beat intervals (RRI) during inspiration and RRI increase expiration, but an inverse pattern (termed negative RSA) was also found in healthy humans with elevated anxiety. It detected using wave-by-wave analysis cardiorespiratory rhythms considered to reflect a strategy anxiety management involving the activation neural pacemaker. Results were consistent slow breathing, contained uncertainty at normal breathing rates (0.2-0.4 Hz).We combined directed information flow obtain on higher rates. We analyzed blood oxygen level-dependent (BOLD) signals from brainstem cortex 10 fMRI participants anxiety.Three subjects respiratory, RRI, BOLD oscillations showed 57 ± 26% RSA significant reduction by 54 9%. Six rate ~0.3 Hz 41 16% weaker reduction. They presented respiration middle frontal brainstem, which may result respiration-entrained brain oscillations, indicating another strategy.The two analytical approaches applied here indicate least different strategies subjects.

Язык: Английский

Процитировано

14
A century of exercise physiology: key concepts in neural control of the circulation DOI Creative Commons
J. Kevin Shoemaker, Robert Gros

European Journal of Applied Physiology, Год журнала: 2024, Номер 124(5), С. 1323 - 1336

Опубликована: Март 5, 2024

Abstract Early in the twentieth century, Walter B. Cannon (1871–1945) introduced his overarching hypothesis of “ homeostasis” (Cannon 1932)—the ability to sustain physiological values within a narrow range necessary for life during periods stress. Physical exercise represents stress which motor, respiratory and cardiovascular systems must be integrated across metabolic match oxygen delivery need at cellular level, together with appropriate thermoregulatory control, blood pressure adjustments energy provision. Of these, regulation is complex but controlled variable, being function cardiac output vascular resistance (or conductance). Key understanding control coordinating role autonomic nervous system. A long history outlines development these concepts how they are context. This review focuses on renaissance observations thinking generated first three decades century that opened doorway new inquiry exercise. The addressed here include following: (1) pressure, (2) central command, (3) neurovascular transduction emphasis sympathetic nerve activity end organ response, (4) tonic integration.

Язык: Английский

Процитировано

6
Neuroanatomical frameworks for volitional control of breathing and orofacial behaviors DOI
Pedro Trevizan‐Baú, Davor Stanić, Werner I. Furuya

и другие.

Respiratory Physiology & Neurobiology, Год журнала: 2024, Номер 323, С. 104227 - 104227

Опубликована: Янв. 29, 2024

Язык: Английский

Процитировано

5
Central control of cardiac activity as assessed by intra-cerebral recordings and stimulations DOI Creative Commons
Laure Mazzola, François Mauguı̀ere, Florian Chouchou

и другие.

Neurophysiologie Clinique, Год журнала: 2023, Номер 53(2), С. 102849 - 102849

Опубликована: Март 1, 2023

Язык: Английский

Процитировано

12
Putting back respiration into respiratory sinus arrhythmia or high-frequency heart rate variability: Implications for interpretation, respiratory rhythmicity, and health DOI Creative Commons
Thomas Ritz

Biological Psychology, Год журнала: 2023, Номер 185, С. 108728 - 108728

Опубликована: Дек. 11, 2023

Язык: Английский

Процитировано

11
The multifunctionality of the brainstem breathing control circuit DOI Creative Commons
Kevin Yackle, Jeehaeh Do

Current Opinion in Neurobiology, Год журнала: 2025, Номер 90, С. 102974 - 102974

Опубликована: Янв. 28, 2025

Subconscious breathing is generated by a network of brainstem nodes with varying purposes, like pacing or patterning certain breath phase. Decades anatomy, pharmacology, and physiology studies have identified characterized the system's fundamental properties that produce robust breathing, we now well-conceived computational models are based on detailed descriptions neuronal connectivity, biophysical properties, functions in breathing. In total, considerable understanding control circuit. But, last five years, utilization molecular genetic approaches to study neural subtypes within each node has led new era circuit research explains how integrated more complex behaviors speaking running connected other physiological systems our state-of-mind. This review will describe basic role key components then highlight transformative discoveries broaden these brain areas. These serve illustrate creativity exciting future research.

Язык: Английский

Процитировано

0