bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 29, 2025
Neurons
are
precisely
and
reproducibly
assembled
into
complex
networks
during
development.
How
genes
collaborate
to
guide
this
assembly
remains
an
enduring
mystery.
In
humans,
large
numbers
of
have
been
implicated
in
neurodevelopmental
disorders
that
characterized
by
variable
overlapping
phenotypes.
The
complexity
the
brain,
number
involved
heterogeneity
makes
understanding
relationships
between
genes,
development
neural
function
challenging.
Waddington
suggested
concept
canalization
describe
role
shaping
developmental
trajectories
lead
precise
outcomes1
.
Here,
we
show
members
δ-protocadherin
family
homophilic
adhesion
molecules,
Protocadherin-19
Protocadherin-17,
contribute
visual
circuit
zebrafish.
We
provided
oriented
stimuli
zebrafish
larvae
performed
vivo
2-photon
calcium
imaging
optic
tectum.
latent
dynamics
resulting
from
population
activity
were
confined
a
conserved
manifold.
Among
different
wild
type
larvae,
these
remarkably
similar,
allowing
quantitative
comparisons
within
among
genotypes.
both
Protocadherin-17
mutants,
diverged
type.
Importantly,
deviations
could
be
averaged
away,
suggesting
loss
molecules
leads
stochastic
phenotypic
variability
introduced
disruptions
organization
varied
individual
mutants.
These
results
provide
specific,
example
vertebrate
circuit,
suggest
framework
for
observed
brain
disorders.
Systems,
Год журнала:
2022,
Номер
10(2), С. 26 - 26
Опубликована: Март 2, 2022
DSRP
Theory
is
now
over
25
years
old
with
more
empirical
evidence
supporting
it
than
any
other
systems
thinking
framework.
Yet,
often
misunderstood
and
described
in
ways
that
are
inaccurate.
describes
four
patterns
their
underlying
elements—identity
(i)
(o)
for
Distinctions
(D),
part
(p)
whole
(w)
Systems
(S),
action
(a)
reaction
(r)
Relationships
(R),
point
(ρ)
view
(v)
Perspectives
(P)—that
universal
both
cognitive
complexity
(mind)
material
(nature).
provides
a
basis
or
as
well
(systems
science).
This
paper,
relatively
short
primer
on
the
theory,
clarity
to
those
wanting
understand
its
implications.
Human Molecular Genetics,
Год журнала:
2022,
Номер
31(16), С. 2711 - 2727
Опубликована: Март 17, 2022
Wolfram
syndrome
(WS)
is
a
rare
genetic
disease
characterized
by
diabetes,
optic
atrophy
and
deafness.
Patients
die
at
35
years
of
age,
mainly
from
respiratory
failure
or
dysphagia.
Unfortunately,
there
no
treatment
to
block
the
progression
symptoms
an
urgent
need
for
adequate
research
models.
Here,
we
report
on
phenotypical
characterization
two
loss-of-function
zebrafish
mutant
lines:
wfs1aC825X
wfs1bW493X.
We
observed
that
wfs1a
deficiency
altered
size
ear
retina
fish.
also
documented
decrease
in
expression
level
unfolded
protein
response
(UPR)
genes
basal
condition
stress
condition,
i.e.
after
tunicamycin
treatment.
Interestingly,
both
mutants
lead
their
visual
function
measured
behaviorally.
These
deficits
were
associated
with
UPR
conditions.
basal,
ATP-linked
maximal
mitochondrial
respirations
transiently
decreased
wfs1b
mutant.
Taken
together,
these
lines
highlight
critical
role
UPR,
physiology.
models
will
be
useful
tools
better
understand
cellular
Wfs1
develop
novel
therapeutic
approaches
WS.
Journal of Systems Thinking,
Год журнала:
2023,
Номер
3
Опубликована: Янв. 1, 2023
This
paper
posits
that
universal
atomic
elements
exist
underlie
complex
cognition.
At
its
core,
constructs
are
born
of
the
dynamics
thinking
operating
on
information.
elemental
understanding
structural
underpinnings
-
and
between
among
provides
insight
into
value
awareness
one’s
to
everyday
life
scientific
inquiry.
Knowledge
dynamical
properties
human
thought
leads
generative,
purposeful,
predictive
cognitive
acts
evolve
thinking.
As
a
result,
our
mental
models
(comprised
information
thinking)
how
systems
work
better
aligned
with
they
in
real
world.
alignment
yields
solutions,
innovation
results.
Continued
inquiry
universality
these
has
significant
potential
advance
across
wide
variety
academic
disciplines.
In
other
words,
study
cognition
is
deemed
synonymous
evolution
science
knowledge
itself.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 29, 2025
Neurons
are
precisely
and
reproducibly
assembled
into
complex
networks
during
development.
How
genes
collaborate
to
guide
this
assembly
remains
an
enduring
mystery.
In
humans,
large
numbers
of
have
been
implicated
in
neurodevelopmental
disorders
that
characterized
by
variable
overlapping
phenotypes.
The
complexity
the
brain,
number
involved
heterogeneity
makes
understanding
relationships
between
genes,
development
neural
function
challenging.
Waddington
suggested
concept
canalization
describe
role
shaping
developmental
trajectories
lead
precise
outcomes1
.
Here,
we
show
members
δ-protocadherin
family
homophilic
adhesion
molecules,
Protocadherin-19
Protocadherin-17,
contribute
visual
circuit
zebrafish.
We
provided
oriented
stimuli
zebrafish
larvae
performed
vivo
2-photon
calcium
imaging
optic
tectum.
latent
dynamics
resulting
from
population
activity
were
confined
a
conserved
manifold.
Among
different
wild
type
larvae,
these
remarkably
similar,
allowing
quantitative
comparisons
within
among
genotypes.
both
Protocadherin-17
mutants,
diverged
type.
Importantly,
deviations
could
be
averaged
away,
suggesting
loss
molecules
leads
stochastic
phenotypic
variability
introduced
disruptions
organization
varied
individual
mutants.
These
results
provide
specific,
example
vertebrate
circuit,
suggest
framework
for
observed
brain
disorders.
