Nature Cell Biology,
Год журнала:
2024,
Номер
26(12), С. 2020 - 2034
Опубликована: Ноя. 11, 2024
The
vasculature
of
the
skeletal
system
is
crucial
for
bone
formation,
homoeostasis
and
fracture
repair,
yet
diversity
specialization
bone-associated
vessels
remain
poorly
understood.
Here
we
identify
a
specialized
type
post-arterial
capillary,
termed
R,
involved
in
remodelling.
Type
R
capillaries
emerge
during
adolescence
around
trabecular
bone,
possess
distinct
morphology
molecular
profile,
are
associated
with
osteoprogenitors
bone-resorbing
osteoclasts.
Endothelial
cell-specific
overexpression
transcription
factor
DACH1
postnatal
mice
induces
strong
increase
arteries
capillaries,
leading
to
local
metabolic
changes
enabling
formation
normally
highly
hypoxic
areas
diaphysis.
Indicating
potential
clinical
relevance
these
respond
anti-osteoporosis
treatments
ageing
inside
porous
structures
that
known
weaken
compact
bone.
Our
work
outlines
fundamental
principles
vessel
developing,
adult
system.
Central European Journal of Immunology,
Год журнала:
2023,
Номер
48(4), С. 338 - 345
Опубликована: Янв. 1, 2023
AMA
LI
H,
WU
Q,
TENG
X,
et
al.
The
pathogenesis
and
regulatory
role
of
HIF-1
in
rheumatoid
arthritis.
Central
European
Journal
Immunology.
2024.
doi:10.5114/ceji.2023.134217.
APA
LI,
H.,
WU,
Q.,
TENG,
X.,
Z.,
ZHU,
M.,
&
GU,
C.
(2024).
https://doi.org/10.5114/ceji.2023.134217
Chicago
HAN,
QI-YANG
XU-HENG
ZHI-PENG
MENG-TING
CHAO-JIE
BEN-JIA
CHEN
"The
arthritis".
Harvard
C.,
CHEN,
B.,
XIE,
LUO,
X.
MLA
HAN
arthritis."
Immunology,
Vancouver
Z,
ZHU
M,
GU
C
Abstract
The
skeletal
system
provides
vital
importance
to
support
organ
development
and
functions.
Notch
signaling
pathway
possesses
well‐established
functions
in
cellular
homeostasis.
comprises
five
typical
ligands
(
JAG1
,
JAG2,
DLL1,
DLL3,
DLL4),
four
receptors
1‐4),
intracellular
domains
(NICD1‐4).
Each
component
of
the
has
been
demonstrated
be
fundamental
osteoblast
differentiation
bone
formation.
dysregulation
is
highly
linked
with
disorders
or
diseases
at
developmental
postnatal
stages.
Recent
studies
have
highlighted
elements
system,
as
well
its
interaction
signaling,
such
Wnt/β‐catenin,
BMP,
TGF‐β,
FGF,
autophagy,
hedgehog
(Hh)
construct
a
potential
gene
regulatory
network
orchestrate
osteogenesis
ossification.
Our
review
provided
comprehensive
summary
insights
targeting
for
innovative
drug
discovery
targets
therapeutic
interventions
treat
disorders,
osteoporosis
osteoarthritis.
An
in‐depth
molecular
mechanistic
strategy
modulate
associated
will
encouraged
consideration
trigger
enhanced
approaches
by
defining
Notch‐regulating
drugs
clinical
use.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
169, С. 115884 - 115884
Опубликована: Ноя. 17, 2023
Degenerative
musculoskeletal
disorders
are
a
group
of
age-related
diseases
the
locomotive
system
that
severely
affects
patient's
ability
to
work
and
cause
adverse
sequalae
such
as
fractures
even
death.
The
incidence
prevalence
degenerative
is
rising
owing
aging
world's
population.
Notch
signaling
pathway,
which
expressed
in
almost
all
organ
systems,
extensively
regulates
cell
proliferation
differentiation
well
cellular
fate.
shows
increased
activity
retards
progression
degeneration
some
extent.
review
focuses
on
four
major
(osteoarthritis,
intervertebral
disc
degeneration,
osteoporosis,
sarcopenia)
summarizes
pathophysiological
functions
these
disorders,
especially
its
role
stem/progenitor
cells
each
disorder.
Finally,
conclusion
will
be
presented
explore
research
application
perspectives
disorders.
Frontiers in Immunology,
Год журнала:
2023,
Номер
13
Опубликована: Янв. 12, 2023
Traumatic
heterotopic
ossification
(HO)
is
an
intractable
sequela
incited
by
inflammatory
insult.
To
date,
the
exact
molecular
mechanisms
of
traumatic
HO
formation
remain
unclear.
Recent
studies
have
indicated
that
circular
RNAs
(circRNAs)
participate
in
various
human
skeletal
diseases.
Although
recapitulates
many
programs
during
bone
development
and
remodeling,
few
data
are
available
concerning
whether
circRNAs
could
this
pathological
osteogenesis.To
investigate
differentially
expressed
(DE-circRNAs)
formation,
microarray
assay
was
performed
to
analyze
circRNA
expression
profile
four
pairs
mice
tissues
normal
tissues.
Then,
qRT-PCR
applied
verify
data.
Gene
Ontology
(GO)
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
analyses
showed
biological
functions
target
genes.
Cytoscape
software
used
construct
circRNA-miRNA-mRNA
network
for
with
different
levels
as
well
genes.We
demonstrated
491
were
significantly
mouse
a
fold-change
≥
2
p-value
≤
0.05.
Among
them,
expressions
168
increased,
while
323
decreased.
The
10
selected
verified
successfully
qRT-PCR.
GO
analysis
exhibited
these
DE-circRNAs
participated
series
cellular
processes.
KEGG
pathway
revealed
multiple
upregulated
downregulated
pathways
closely
related
mice.
networks
may
be
involved
osteogenesis
through
circRNA-targeted
miRNA-mRNA
axis.Our
study
first
profiles
predicted
potential
HO,
which
shed
new
light
on
elucidation
provide
novel
peripheral
diagnostic
markers
therapeutic
targets
HO.
Frontiers in Endocrinology,
Год журнала:
2023,
Номер
14
Опубликована: Май 9, 2023
Bone
contributes
to
the
maintenance
of
vital
biological
activities.
At
cellular
level,
multiple
types
skeletal
cells,
including
stem
and
progenitor
cells
(SSPCs),
osteoblasts,
chondrocytes,
marrow
stromal
adipocytes,
orchestrate
events
such
as
development,
aging,
regeneration,
tumorigenesis.
Osteosarcoma
(OS)
is
a
primary
malignant
tumor
main
form
bone
cancer.
Although
it
has
been
proposed
that
origins
OS
are
in
osteogenesis-related
lineage
with
cancer
suppressor
gene
mutations,
its
have
not
yet
fully
elucidated
because
poor
understanding
whole
cell
diversity
dynamics.
Over
past
decade,
advent
development
single-cell
RNA
sequencing
analyses
mouse
lineage-tracing
approaches
revealed
cells.
Skeletal
(SSCs)
endoskeletal
region
now
found
efficiently
generate
be
robust
origin
under
p53
deletion
conditions.
The
identification
SSCs
may
lead
more
limited
redefinition
mesenchymal
stem/stromal
(BM-MSCs),
this
population
thought
contain
from
which
originates.
In
mini-review,
we
discuss
dynamics
native
vivo
environment
mice.
We
also
future
challenges
study
OS.
Journal of Biochemical and Molecular Toxicology,
Год журнала:
2024,
Номер
38(7)
Опубликована: Июнь 25, 2024
Osteomyelitis
is
an
invasive
bone
infection
that
can
lead
to
severe
pain
and
even
disability,
posing
a
challenge
for
orthopedic
surgery.
Naringin
reduce
bone-related
inflammatory
conditions.
This
study
aimed
elucidate
the
function
mechanism
of
naringin
in
Staphylococcus
aureus-induced
mouse
model
osteomyelitis.
Femurs
S.
aureus-infected
mice
were
collected
after
administration
subjected
microcomputed
tomography
analyze
cortical
destruction
loss.
Bacterial
growth
femurs
was
also
assessed.
Proinflammatory
cytokine
levels
measured
using
enzyme-linked
immunosorbent
assays.
Pathological
changes
resorption
analyzed
hematoxylin
eosin
staining
tartrate-resistant
acid
phosphatase
staining,
respectively.
Quantitative
reverse
transcription
polymerase
chain
reaction
western
blot
analysis
used
quantify
messenger
RNA
protein
expression
osteogenic
differentiation-associated
genes
femurs.
The
viability
human
marrow-derived
stem
cells
(hBMSCs)
determined
cell
counting
kit-8.
Alizarin
Red
S
alkaline
performed
assess
formation
mineralization
nodules
vitro.
Notch
signaling-related
femur
tissues
hBMSCs
assessed
analysis.
Experimental
results
revealed
alleviated
loss
by
increasing
volume/total
volume
ratio.
suppressed
bacterial
inflammation
Moreover,
it
histopathological
changes,
inhibited
resorption,
increased
markers
osteomyelitic
mice.
It
promoted
their
differentiation
Furthermore,
activated
signaling
upregulating
Notch1,
Jagged1,
Hes1
aureus-stimulated
hBMSCs.
In
conclusion,
reduces
growth,
inflammation,
while
activating
signaling.
