World Journal of Gastrointestinal Oncology,
Год журнала:
2024,
Номер
16(4), С. 1564 - 1577
Опубликована: Апрель 9, 2024
Colorectal
cancer
(CRC)
is
the
third
most
common
and
a
significant
cause
of
cancer-related
mortality
globally.
Resistance
to
chemotherapy,
especially
during
CRC
treatment,
leads
reduced
effectiveness
drugs
poor
patient
outcomes.
Long
noncoding
RNAs
(lncRNAs)
have
been
implicated
in
various
pathophysiological
processes
tumor
cells,
including
chemotherapy
resistance,
yet
roles
many
lncRNAs
remain
unclear.
Progress in Retinal and Eye Research,
Год журнала:
2022,
Номер
91, С. 101093 - 101093
Опубликована: Июль 8, 2022
The
development
of
the
vertebrate
eyes
is
a
complex
process
starting
from
anterior-posterior
and
dorso-ventral
patterning
anterior
neural
tube,
resulting
in
formation
eye
field.
Symmetrical
separation
field
at
plate
followed
by
two
symmetrical
evaginations
to
generate
pair
optic
vesicles.
Next,
reciprocal
invagination
vesicles
with
surface
ectoderm-derived
lens
placodes
generates
double-layered
cups.
inner
outer
layers
cups
develop
into
retina
retinal
pigment
epithelium
(RPE),
respectively.
In
vitro
produced
tissues,
called
organoids,
are
formed
human
pluripotent
stem
cells,
mimicking
major
steps
differentiation
vivo.
This
review
article
summarizes
recent
progress
our
understanding
early
development,
focusing
on
field,
vesicles,
Recent
single-cell
transcriptomic
studies
integrated
classical
vivo
genetic
functional
uncover
range
cellular
mechanisms
underlying
development.
functions
signal
transduction
pathways
lineage-specific
DNA-binding
transcription
factors
dissected
explain
cell-specific
regulatory
cell
fate
determination
during
homeodomain
(HD)
Otx2,
Pax6,
Lhx2,
Six3
Six6,
which
required
for
discussed
detail.
Comprehensive
provides
insight
molecular
basis
developmental
ocular
anomalies,
such
as
cup
coloboma.
Lastly,
modeling
inherited
diseases
using
cell-derived
organoids
opportunities
discover
novel
therapies
diseases.
Journal of Experimental & Clinical Cancer Research,
Год журнала:
2023,
Номер
42(1)
Опубликована: Июль 18, 2023
Cancer
is
the
main
cause
of
death
worldwide
and
metastasis
a
major
poor
prognosis
cancer-associated
mortality.
Metastatic
conversion
cancer
cells
multiplex
process,
including
EMT
through
cytoskeleton
remodeling
interaction
with
TME.
Tens
thousands
putative
lncRNAs
have
been
identified,
but
biological
functions
most
are
still
to
be
identified.
However,
already
emerged
as
key
regulators
gene
expression
at
transcriptional
post-transcriptional
level
control
in
spatio-temporal
fashion.
LncRNA-dependent
mechanisms
can
cell
fates
during
development
their
perturbed
associated
onset
progression
many
diseases
cancer.
LncRNAs
involved
each
step
different
modes
action.
The
investigation
roles
could
possibly
lead
identification
new
biomarkers
innovative
therapeutic
options.
Abstract
Recent
studies
have
revealed
that
numerous
lncRNAs
can
translate
proteins
under
specific
conditions,
performing
diverse
biological
functions,
thus
termed
coding
lncRNAs.
Their
comprehensive
landscape,
however,
remains
elusive
due
to
this
field's
preliminary
and
dispersed
nature.
This
study
introduces
codLncScape,
a
framework
for
lncRNA
exploration
consisting
of
codLncDB,
codLncFlow,
codLncWeb,
codLncNLP.
Specifically,
it
contains
manually
compiled
knowledge
base,
encompassing
353
entries
validated
by
experiments.
Building
upon
codLncFlow
investigates
the
expression
characteristics
these
their
diagnostic
potential
in
pan‐cancer
context,
alongside
association
with
spermatogenesis.
Furthermore,
codLncWeb
emerges
as
platform
storing,
browsing,
accessing
concerning
within
various
programming
environments.
Finally,
codLncNLP
serves
knowledge‐mining
tool
enhance
timely
content
inclusion
updates
codLncDB.
In
summary,
offers
well‐functioning,
content‐rich
ecosystem
research,
aiming
accelerate
systematic
field.
Pflügers Archiv - European Journal of Physiology,
Год журнала:
2021,
Номер
474(2), С. 191 - 204
Опубликована: Ноя. 17, 2021
Abstract
Long
non-coding
RNAs
were
once
considered
as
“junk”
RNA
produced
by
aberrant
DNA
transcription.
They
are
now
understood
to
play
central
roles
in
diverse
cellular
processes
from
proliferation
and
migration
differentiation,
senescence
damage
control.
LncRNAs
classed
transcripts
longer
than
200
nucleotides
that
do
not
encode
a
peptide.
relevant
many
physiological
pathophysiological
through
their
control
of
fundamental
molecular
functions.
This
review
summarises
the
recent
progress
lncRNA
research
highlights
far-reaching
relevance
lncRNAs.
The
main
areas
encompassing
characterisation,
classification
mechanisms
action
will
be
discussed.
In
particular,
regulation
gene
expression
chromatin
landscape
proteins,
other
introduced.
exemplified
with
selected
number
lncRNAs
have
been
described
numerous
contexts
should
largely
representative
tens-of-thousands
mammalian
To
some
extent,
these
inspired
current
thinking
on
dogmas
epigenetics,
mechanisms.
Breast
cancer
is
the
most
common
malignancy
among
women
and
leading
cause
of
deaths,
with
complicated
pathogenesis
that
largely
unknown.
In
this
study,
we
identified
a
novel
long
non-coding
RNA
(lncRNA)
as
critical
driver
breast
tumorigenesis.
RUNX1
intronic
transcript
1
(RUNX1-IT1)
was
notably
overexpressed
in
human
tissues,
knockdown
RUNX1-IT1
inhibited
cell
viability
invasion,
well
tumor
growth
orthotopic
transplantation
model.
Further,
repressed
ferroptosis,
iron-dependent
form
regulated
death,
via
increasing
glutathione
peroxidase
4
(GPX4)
expression.
Specifically,
directly
bound
to
N6-methyladenosine
m6A
reader
IGF2BP1
promoted
formation
(insulin
like
factor
2
mRNA
binding
protein
1)
liquid-liquid
phase
separation
(LLPS)
biomolecular
condensates,
resulting
more
occupation
on
GPX4
mRNA,
stability.
Moreover,
high
linked
poor
prognosis,
strong
positive
correlation
between
observed
clinical
tissues.
Taken
together,
our
data
reveal
promotes
carcinogenesis
through
blocking
ferroptosis
elevating
GPX4,
targeting
previously
unappreciated
regulatory
axis
RUNX1-IT1/IGF2BP1/GPX4
may
be
promising
treatment
for
patient
cancer.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Май 23, 2024
Hepatocellular
carcinoma
is
the
most
common
form
of
primary
liver
cancer
and
poses
a
significant
challenge
to
medical
community
because
its
high
mortality
rate.
In
recent
years,
ferroptosis,
unique
cell
death,
has
garnered
widespread
attention.
Ferroptosis,
which
characterized
by
iron-dependent
lipid
peroxidation
mitochondrial
alterations,
closely
associated
with
pathological
processes
various
diseases,
including
hepatocellular
carcinoma.
Long
non-coding
RNAs
(lncRNAs),
are
type
functional
RNA,
play
crucial
regulatory
roles
in
variety
biological
processes.
this
manuscript,
we
review
lncRNAs
key
aspects
summarize
research
progress
on
ferroptosis-related
Cancer Cell International,
Год журнала:
2025,
Номер
25(1)
Опубликована: Апрель 1, 2025
Cancer
is
a
rising
issue
worldwide,
and
numerous
studies
have
focused
on
understanding
the
underlying
reasons
for
its
occurrence
finding
proper
ways
to
defeat
it.
By
applying
technological
advances,
researchers
are
continuously
uncovering
updating
treatments
in
cancer
therapy.
Their
vast
functions
regulation
of
cell
growth
proliferation
their
significant
role
progression
diseases,
including
cancer.
This
review
provides
comprehensive
analysis
ncRNAs
breast
cancer,
focusing
long
non-coding
RNAs
such
as
HOTAIR,
MALAT1,
NEAT1,
well
microRNAs
miR-21,
miR-221/222,
miR-155.
These
pivotal
regulating
proliferation,
metastasis,
drug
resistance,
apoptosis.
Additionally,
we
discuss
experimental
approaches
that
useful
studying
them
highlight
advantages
challenges
each
method.
We
then
explain
results
these
clinical
trials
offer
insights
future
by
discussing
major
existing
gaps.
On
basis
an
extensive
number
studies,
this
valuable
into
potential
Key
findings
show
even
though
undeniable
there
still
complications
associated
with
therapeutic
use.
Moreover,
absence
sufficient
experiments
regarding
application
mouse
models,
which
area
work
on.
emphasizing
crucial
ncRNAs,
underscores
need
innovative
further
explore
