International Journal of experimental research and review,
Год журнала:
2024,
Номер
37, С. 149 - 158
Опубликована: Март 30, 2024
In
the
twenty-first
century,
there
have
been
a
number
of
outbreaks,
beginning
with
dengue,
swine
flu,
Nipah,
Ebola,
chikungunya,
and
Zika,
which
were
continuously
outbreaks
in
some
specific
regions.
The
mosquito-transmitted
flavivirus
Japanese
encephalitis
(JE)
virus,
similar
to
dengue
fever
West
Nile
viruses,
negative-single-stranded
Ebola
virus
(EBOV)
are
two
most
emerging
WHO's
most-prioritized
diseases.
Natural
products
always
served
as
an
alternative
mainstream
drugs
emergencies.
Thus,
due
their
excellent
antiviral
activity,
present
study
focused
on
marine
alkaloids
assessed
potency
against
JE
EBOV
viruses.
Using
various
bioinformatics
tools,
we
selected
60
different
for
anti-JE
activity
RNA-dependent
RNA
polymerase
(PDB
ID:
4HDG),
NS3-helicase
2Z83),
NS5-protease
4K6M),
well
anti-EBOV
efficacy
targeting
nucleoprotein
4Z9P),
viral
protein
24
4M0Q),
40
3TCQ).
Based
previous
records
combined
molecular
docking
scores,
physicochemical,
toxicity,
pharmacokinetic,
drug-ability
profiles,
researchers
concluded
that
manzamines
A,
F,
X
6-deoxymanzamine
8-hydroxymanzamine
may
be
best
among
all
candidates
EV
infection
control.
summary,
exhibit
need
explored
more
bioactive
drug
discovery,
where
tools
cost-effective,
resource-efficient,
time-saving
platform
than
traditional
discovery
modules
locate
lead
used
medicine
health
conditions.
ACS Infectious Diseases,
Год журнала:
2024,
Номер
10(3), С. 808 - 826
Опубликована: Фев. 28, 2024
Recent
pandemics,
including
the
COVID-19
outbreak,
have
brought
up
growing
concerns
about
transmission
of
zoonotic
diseases
from
animals
to
humans.
This
highlights
requirement
for
a
novel
approach
discern
and
address
escalating
health
threats.
The
One
Health
paradigm
has
been
developed
as
responsive
strategy
confront
forthcoming
outbreaks
through
early
warning,
highlighting
interconnectedness
humans,
animals,
their
environment.
system
employs
several
innovative
methods
such
use
advanced
technology,
global
collaboration,
data-driven
decision-making
come
with
an
extraordinary
solution
improving
worldwide
disease
responses.
Review
deliberates
environmental,
animal,
human
factors
that
influence
risk,
analyzes
challenges
advantages
inherent
in
using
surveillance
system,
demonstrates
how
these
can
be
empowered
by
Big
Data
Artificial
Intelligence.
Holistic
Surveillance
Framework
presented
herein
holds
potential
revolutionize
our
capacity
monitor,
understand,
mitigate
impact
infectious
on
populations.
Science,
Год журнала:
2022,
Номер
377(6611), С. 1206 - 1211
Опубликована: Сен. 8, 2022
Parasites
impose
fitness
costs
on
their
hosts.
Biologists
often
assume
that
natural
selection
favors
infection-resistant
Yet,
when
the
immune
response
itself
is
costly,
theory
suggests
may
sometimes
favor
loss
of
resistance,
which
result
in
alternative
stable
states
where
some
populations
are
resistant
and
others
tolerant.
Intraspecific
variation
rarely
surveyed
a
manner
tests
evolutionary
patterns,
there
few
examples
adaptive
resistance.
Here,
we
show
marine
threespine
stickleback
colonized
freshwater
lakes,
they
gained
resistance
to
freshwater-associated
cestode
Schistocephalus
solidus.
Extensive
peritoneal
fibrosis
inflammation
commonly
observed
phenotype
contributes
suppression
growth
viability
but
also
imposes
substantial
cost
fecundity.
Combining
genetic
mapping
population
genomics,
find
opposing
generates
system
differences
between
tolerant
populations,
consistent
with
divergent
optimization.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2024,
Номер
13
Опубликована: Янв. 5, 2024
Lung
infections
in
Influenza-Like
Illness
(ILI)
are
triggered
by
a
variety
of
respiratory
viruses.
All
human
pandemics
have
been
caused
the
members
two
major
virus
families,
namely
Orthomyxoviridae
(influenza
A
viruses
(IAVs);
subtypes
H1N1,
H2N2,
and
H3N2)
Coronaviridae
(severe
acute
syndrome
coronavirus
2,
SARS−CoV−2).
These
acquired
some
adaptive
changes
known
intermediate
host
including
domestic
birds
(IAVs)
or
unknown
(SARS-CoV-2)
following
transmission
from
their
natural
reservoirs
(e.g.
migratory
bats,
respectively).
Verily,
these
substitutions
facilitated
crossing
species
barriers
to
infect
humans
phenomenon
that
is
as
zoonosis.
Besides,
aided
variant
strain
transmit
horizontally
other
contact
non-human
animal
pets
wild
animals
(zooanthroponosis).
Herein
we
discuss
main
zoonotic
reverse-zoonosis
events
occurred
during
last
influenza
A/H1N1
SARS-CoV-2.
We
also
highlight
impact
interspecies
pandemic
on
evolution
possible
prophylactic
therapeutic
interventions.
Based
information
available
presented
this
review
article,
it
important
close
monitoring
viral
zoonosis
reverse
strains
within
One-Health
One-World
approach
mitigate
unforeseen
risks,
such
resistance
limited
Applied Microbiology,
Год журнала:
2024,
Номер
4(2), С. 594 - 606
Опубликована: Март 25, 2024
The
transformation
of
the
food
chain
due
to
technological
advances
has
had
significant
implications
in
regard
safety.
A
noteworthy
trend
this
evolution
relates
emergence
new
or
previously
unseen
pathogens
within
products,
thereby
altering
landscape
foodborne
illness
epidemiology.
escalating
frequency
these
events
underscores
need
for
a
comprehensive
re-evaluation
preventive
strategies.
occurrence
novel
species
bacteria,
viruses,
parasites,
and
unusual
biotoxins
from
unexpected
sources
challenged
previous
limits
that
been
set
prevent
outbreaks.
repercussions,
ranging
detrimental
effects
on
public
health
economic
burden,
are
influenced
by
myriad
factors
affecting
emerging
ailments.
Among
shifts
population
demographics
behaviors,
especially
dietary
patterns,
as
well
climate
extremes,
more
precise
pathogen
detection,
microbial
adaptation,
evolving
agricultural
practices,
transformative
changes
industry.
This
review
critically
examines
impact
metamorphosis
along
chain,
encompassing
production,
processing,
handling,
packaging,
storage,
transportation,
industry
dynamics
influencing
pathogens.
Additionally,
potential
solutions
mitigate
manage
issue
proposed.
One Health Advances,
Год журнала:
2024,
Номер
2(1)
Опубликована: Янв. 11, 2024
Abstract
Avian-origin
H3N2
canine
influenza
virus
(CIV)
is
one
of
the
most
prevalent
subtypes
in
dogs
worldwide.
Previous
studies
have
shown
that
during
evolution
CIV
dogs,
its
adaptability
mammals
increased
gradually,
suggesting
can
serve
as
a
potential
intermediate
host
for
cross-species
transmission
avian
virus.
In
this
study,
we
report
results
from
surveillance
and
characterization
CIVs
isolated
animal
hospitals
kennels
2021
China.
We
characterized
CIVs’
genetic
antigenic
variation,
receptor-binding
specificity,
virulence
mice.
The
hemagglutinin
(HA)
phylogenetic
result
showed
these
belonged
to
Clade
5.1,
clade
formed
after
2019.
Compared
2016–2019
strains
China,
had
similar
antigenicity
specificity.
pathogenicity
mice
was
significantly
reduced
infection
with
two
strains,
but
replication
capacity
similar,
virus-host
balance
might
been
established.
This
emphasizes
importance
close
monitoring
prevent
emergence
novel
viruses
public
health
threats.
