Avian influenza A (H5N1) virus in dairy cattle: origin, evolution, and cross-species transmission
mBio,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 13, 2024
Since
the
emergence
of
highly
pathogenic
avian
influenza
virus
(HPAIV)
H5N1
clade
2.3.4.4b
as
a
novel
reassortant
from
subtype
H5N8,
has
led
to
massive
number
outbreaks
worldwide
in
wild
and
domestic
birds.
Compared
parental
HPAIV
H5N8
2.3.4.4b,
displayed
an
increased
ability
escape
species
barriers
infect
multiple
mammalian
species,
including
humans.
The
host
range
been
recently
expanded
include
ruminants,
particularly
dairy
cattle
United
States,
where
cattle-to-cattle
transmission
was
reported.
As
with
2.3.4.4.b
viruses,
cattle-infecting
found
transmit
other
contact
animals
cats,
raccoons,
rodents,
opossums,
poultry.
Although
replication
cows
appears
be
mainly
confined
mammary
tissue,
high
levels
viral
loads
detected
milk,
infected
cats
poultry
showed
severe
respiratory
disease,
neurologic
signs,
eventually
died.
Furthermore,
several
human
infections
have
also
reported
farm
workers
were
attributed
exposures
cattle.
This
is
believed
represent
first
mammalian-to-human
report
H5N1.
Fortunately,
infection
humans
cows,
opposed
animals,
mild
most
cases.
Nevertheless,
bovine
outbreak
represents
largest
mammal
close
humans,
increasing
risk
that
this
already
adapted
further
adapts
human-to-human
starts
pandemic.
Herein,
we
discuss
epidemiology,
evolution,
pathogenesis,
potential
impact
identified
States.
Eventually,
interdisciplinary
cooperation
under
One
Health
framework
required
able
control
ongoing
stop
it
before
expansion
its
geographical
distribution.
Язык: Английский
The introduction of the SARS-CoV-2 BA.4 lineage into Pakistan
Archives of Virology,
Год журнала:
2025,
Номер
170(2)
Опубликована: Янв. 6, 2025
Язык: Английский
Dynamics of influenza transmission in vampire bats revealed by longitudinal monitoring and a large-scale anthropogenic perturbation
Science Advances,
Год журнала:
2025,
Номер
11(6)
Опубликована: Фев. 5, 2025
Interrupting
pathogen
transmission
between
species
is
a
priority
strategy
to
mitigate
zoonotic
threats.
However,
avoiding
counterproductive
interventions
requires
knowing
animal
reservoirs
of
infection
and
the
dynamics
within
them,
neither
which
are
easily
ascertained
from
cross-sectional
surveys
that
now
dominate
investigations
into
newly
discovered
viruses.
We
used
biobanked
sera
metagenomic
data
reconstruct
recently
bat-associated
influenza
virus
(BIV;
H18N11)
over
12
years
in
three
zones
Peru.
Mechanistic
models
fit
under
Bayesian
framework,
enabled
joint
inference
serological
molecular
data,
showed
common
vampire
bats
maintain
BIV
independently
assumed
fruit
bat
reservoir
through
immune
waning
seasonal
pulses.
A
large-scale
cull
targeting
rabies
incidentally
halved
transmission,
confirming
as
maintenance
hosts.
Our
results
show
how
combining
field
studies,
perturbation
responses,
multi-data–type
can
elucidate
nature
reveal
pathogen-dependent
effects
interventions.
Язык: Английский
Mycophenolate mofetil exerts broad-spectrum antiviral activity against coronaviruses including SARS-CoV-2
Virology Journal,
Год журнала:
2025,
Номер
22(1)
Опубликована: Март 4, 2025
Язык: Английский
Swine Influenza (H1N1)
Опубликована: Фев. 28, 2025
Challenges and Opportunities for Wastewater Monitoring of Influenza Viruses During the Multistate Outbreak of Highly Pathogenic Avian Influenza A(H5N1) Virus in Dairy Cattle and Poultry
American Journal of Public Health,
Год журнала:
2024,
Номер
unknown, С. e1 - e4
Опубликована: Сен. 19, 2024
Язык: Английский
Mosquito bloodmeals can be used to determine vertebrate diversity, host preference, and pathogen exposure in humans and wildlife
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Фев. 21, 2024
Abstract
The
surveillance
and
detection
of
zoonotic
pathogens
in
animals
is
essential
for
predicting
disease
transmission
pathways
the
risks
spillover,
but
challenges
include
costs,
ethics
technical
expertise
required
vertebrate
trapping,
serum
sampling
antibody
or
virus
screening.
Surveillance
using
haematophagous
arthropods
as
a
tool
offers
unique
opportunity
to
obtain
blood
samples
from
wide
range
species,
allowing
study
host-mosquito
associations,
host
exposure
pathogens.
We
explored
diversity
potential
Ross
River
(RRV)
by
analysing
blood-fed
mosquitoes
collected
Brisbane,
Australia.
Host
origins
were
identified
barcode
sequencing,
RRV
was
assessed
modified
plaque
reduction
neutralisation
test.
In
total,
480
between
February
2021
May
2022.
346
(72%)
bloodmeals
identified,
with
humans
(73%)
cattle
(9%)
comprising
dominant
hosts.
seroprevalence
high
both
species
evidence
70%
(21/30)
52%
(132/253)
humans.
This
novel,
non-invasive
method
estimating
populations.
Our
results
highlight
provide
species-specific
insights
into
pathogen
dynamics.
Язык: Английский
Mosquito bloodmeals can be used to determine vertebrate diversity, host preference, and pathogen exposure in humans and wildlife
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Окт. 5, 2024
The
surveillance
and
detection
of
zoonotic
pathogens
in
animals
is
essential
for
predicting
disease
transmission
pathways
the
risks
spillover,
but
challenges
include
costs,
ethics
technical
expertise
required
vertebrate
trapping,
serum
sampling
antibody
or
virus
screening.
Surveillance
using
haematophagous
arthropods
as
a
tool
offers
unique
opportunity
to
obtain
blood
samples
from
wide
range
species,
allowing
study
host-mosquito
associations,
host
exposure
pathogens.
We
explored
diversity
potential
Ross
River
(RRV)
by
analysing
blood-fed
mosquitoes
collected
Brisbane,
Australia.
Host
origins
were
identified
barcode
sequencing,
RRV
was
assessed
modified
plaque
reduction
neutralisation
test.
In
total,
480
between
February
2021
May
2022.
346
(72%)
bloodmeals
identified,
with
humans
(73%)
cattle
(9%)
comprising
dominant
hosts.
seroprevalence
high
both
species
evidence
70%
(21/30)
52%
(132/253)
humans.
This
novel,
non-invasive
method
estimating
populations.
Our
results
highlight
provide
species-specific
insights
into
pathogen
dynamics.
Язык: Английский
Dynamics of influenza transmission in vampire bats revealed by longitudinal monitoring and a large-scale anthropogenic perturbation
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 26, 2024
Abstract
Interrupting
pathogen
transmission
between
species
is
a
priority
strategy
to
mitigate
zoonotic
threats.
However,
avoiding
counterproductive
interventions
requires
knowing
animal
reservoirs
of
infection
and
the
dynamics
within
them,
neither
which
are
easily
ascertained
from
cross-sectional
surveys
currently
dominate
investigations
into
newly
discovered
viruses.
We
used
biobanked
sera
metagenomic
data
reconstruct
recently
bat-associated
influenza
virus
(BIV)
over
12
years
in
three
zones
Peru.
Mechanistic
models
fit
under
Bayesian
framework,
enabled
joint
inference
serological
molecular
data,
showed
that
common
vampire
bats
maintain
BIV
independently
assumed
fruit
bat
reservoir
through
immune
waning
seasonal
pulses.
A
large-scale
cull
targeting
rabies
incidentally
halved
transmission,
confirming
as
maintenance
hosts.
Our
results
show
how
combining
field
studies,
perturbation
responses
multi-data
type
can
elucidate
nature
reveal
pathogen-dependent
effects
interventions.
Язык: Английский