Eye saccades align optic flow with retinal specializations during object pursuit in freely moving ferrets

Current Biology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Highlights•Saccades during target pursuit align area centralis with intended direction of travel•Saccades simultaneously also retinal pattern optic flow•Post-saccade eye and head rotation reduce image blur limit information loss•Tree shrews, mice, rats have the same coordinated kineticsSummaryDuring prey pursuit, how rotations, such as saccades, enable continuous tracking erratically moving targets while enabling an animal to navigate through environment is unknown. To better understand this, we measured rotations in freely running ferrets behavior. By all environmental features, reconstructed animal's visual fields their relationship structures. In fields, position clustered on around high-acuity location, centralis, surprisingly, this cluster was not significantly shifted by digital removal either exclusively elicited when made turns, or that were tightly synchronized saccades. Here, show that, saccades did fixate they instead aligned travel. This features flow pattern, focus expansion, used for navigation many species. While initially rotated eyes turn, followed countering ongoing rotation, which reduced limited loss across field turns. As rotational tree rats, suggest these counter-rotations are a generalized mechanism mammals complex environments pursuit.Graphical abstract

Язык: Английский

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A three-photon head-mounted microscope for imaging all layers of visual cortex in freely moving mice

Nature Methods, Год журнала: 2022, Номер 20(4), С. 610 - 616

Опубликована: Ноя. 28, 2022

Abstract Advances in head-mounted microscopes have enabled imaging of neuronal activity using genetic tools freely moving mice but these are restricted to recording minimally lit arenas and upper cortical layers. Here we built a 2-g, three-photon excitation-based microscope, containing z -drive that access all layers while behaved fully environment. The microscope had on-board photon detectors, robust environmental light, the arena lighting was timed end each line-scan, enabling functional from layer 4 6 neurons expressing jGCaMP7f roaming or dark arena. By comparing measured populations show is differentially modulated by conditions during free exploration.

Язык: Английский

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Visual pursuit behavior in mice maintains the pursued prey on the retinal region with least optic flow

eLife, Год журнала: 2021, Номер 10

Опубликована: Окт. 26, 2021

Mice have a large visual field that is constantly stabilized by vestibular ocular reflex (VOR) driven eye rotations counter head-rotations. While maintaining their extensive coverage advantageous for predator detection, mice also track and capture prey using vision. However, in the freely moving animal quantifying object location of view challenging. Here, we developed method to digitally reconstruct quantify scene performing visually based task. By isolating sense combining mouse optic model with head rotations, detailed reconstruction digital environment retinal features were projected onto corneal surface comparison, updated throughout behavior. spatial objects motion behavior, show image consistently falls within small area VOR-stabilized field. This functional focus coincides region minimal flow consequently motion-induced image-blur, as during pursuit ran directly toward prey. The lies upper-temporal part retina reported high density-region Alpha-ON sustained ganglion cells.

Язык: Английский

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Functional Organisation of the Mouse Superior Colliculus

Frontiers in Neural Circuits, Год журнала: 2022, Номер 16

Опубликована: Апрель 29, 2022

The superior colliculus (SC) is a highly conserved area of the mammalian midbrain that widely implicated in organisation and control behaviour. SC receives input from large number brain areas, provides outputs to areas. convergence divergence anatomical connections with different areas systems challenges for understanding how contributes Recent work mouse has provided datasets, wealth new data experiments identify manipulate cells within SC, their inputs outputs, during simple behaviours. These offer an opportunity better understand roles plays these However, some observations appear, at first sight, be contradictory. Here we review this recent hypothesise framework which can capture observations, requires only small change previous models. Specifically, functional explained by supposing three largely distinct circuits support classes behaviours–arrest, turning towards, triggering escape or capture. behaviours are hypothesised supported optic, intermediate deep layers, respectively.

Язык: Английский

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Detailed characterization of neural selectivity in free viewing primates

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Июнь 20, 2023

Abstract Fixation constraints in visual tasks are ubiquitous and cognitive neuroscience. Despite its widespread use, fixation requires trained subjects, is limited by the accuracy of fixational eye movements, ignores role movements shaping input. To overcome these limitations, we developed a suite hardware software tools to study vision during natural behavior untrained subjects. We measured receptive fields tuning properties from multiple cortical areas marmoset monkeys who freely viewed full-field noise stimuli. The resulting curves primary cortex (V1) area MT match reported selectivity literature which was using conventional approaches. then combined free viewing with high-resolution tracking make first detailed 2D spatiotemporal measurements foveal V1. These findings demonstrate power characterize neural responses animals while simultaneously studying dynamics behavior.

Язык: Английский

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Interactions between rodent visual and spatial systems during navigation

Nature reviews. Neuroscience, Год журнала: 2023, Номер 24(8), С. 487 - 501

Опубликована: Июнь 28, 2023

Язык: Английский

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A dynamic sequence of visual processing initiated by gaze shifts

Nature Neuroscience, Год журнала: 2023, Номер 26(12), С. 2192 - 2202

Опубликована: Ноя. 23, 2023

Язык: Английский

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Through Hawks’ Eyes: Synthetically Reconstructing the Visual Field of a Bird in Flight

International Journal of Computer Vision, Год журнала: 2023, Номер 131(6), С. 1497 - 1531

Опубликована: Март 2, 2023

Birds of prey rely on vision to execute flight manoeuvres that are key their survival, such as intercepting fast-moving targets or navigating through clutter. A better understanding the role played by during these is not only relevant within field animal behaviour, but could also have applications for autonomous drones. In this paper, we present a novel method uses computer tools analyse active in bird flight, and demonstrate its use answer behavioural questions. Combining motion capture data from Harris' hawks with hybrid 3D model environment, render RGB images, semantic maps, depth information optic flow outputs characterise visual experience flight. contrast previous approaches, our allows us consider different camera models alternative gaze strategies purposes hypothesis testing, input over complete bird, limited technical specifications performance head-mounted light enough attach bird's head We pilot three sample flights: pursuit which hawk intercepts moving target, two obstacle avoidance flights. With approach, provide reproducible facilitates collection large volumes across many individuals, opening up new avenues data-driven behaviour.The online version contains supplementary material available at 10.1007/s11263-022-01733-2.

Язык: Английский

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Distance estimation from monocular cues in an ethological visuomotor task

eLife, Год журнала: 2022, Номер 11

Опубликована: Сен. 20, 2022

In natural contexts, sensory processing and motor output are closely coupled, which is reflected in the fact that many brain areas contain both movement signals. However, standard reductionist paradigms decouple decisions from their consequences, head-fixation prevents consequences of self-motion. particular, through environment provides a number depth cues beyond stereo vision poorly understood. To study integration visual naturalistic task, we investigated distance estimation freely moving mice. We found mice use to accurately jump across variable gap, thus directly coupling computation its corresponding ethological output. Monocular eyelid suture did not affect gap jumping success, can do depend on binocular disparity vision. Under monocular conditions, altered head positioning performed more vertical movements, consistent with shift using stereopsis other cues, such as motion or position parallax. Finally, optogenetic suppression primary cortex impaired task performance under conditions when optical fiber placement was localized zone V1, respectively. Together, these results show relying cortex, judge distance. Furthermore, this behavioral paradigm foundation for studying how neural circuits convert information into

Язык: Английский

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Natural visual behavior and active sensing in the mouse

Current Opinion in Neurobiology, Год журнала: 2024, Номер 86, С. 102882 - 102882

Опубликована: Май 4, 2024

In the natural world, animals use vision for a wide variety of behaviors not reflected in most laboratory paradigms. Although mice have low-acuity vision, they their many behaviors, including predator avoidance, prey capture, and navigation. They also perform active sensing, moving head eyes to achieve behavioral goals acquire visual information. These aspects result inputs corresponding outputs that are outside range conventional studies but essential function. Here, we review recent tapped into behavior sensing reveal computational logic neural circuits vision.

Язык: Английский

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