Preexisting hippocampal network dynamics constrain optogenetically induced place fields

Neuron, Год журнала: 2021, Номер 109(6), С. 1040 - 1054.e7

Опубликована: Фев. 5, 2021

Язык: Английский

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Bidirectional synaptic plasticity rapidly modifies hippocampal representations

eLife, Год журнала: 2021, Номер 10

Опубликована: Дек. 9, 2021

Learning requires neural adaptations thought to be mediated by activity-dependent synaptic plasticity. A relatively non-standard form of plasticity driven dendritic calcium spikes, or plateau potentials, has been reported underlie place field formation in rodent hippocampal CA1 neurons. Here, we found that this behavioral timescale (BTSP) can also reshape existing fields via bidirectional weight changes depend on the temporal proximity potentials pre-existing fields. When evoked near an field, induced less potentiation and more depression, suggesting BTSP might inversely postsynaptic activation. However, manipulations cell membrane potential computational modeling indicated anti-correlation actually results from a dependence current such weak inputs potentiate strong depress. network model implementing learning rule suggested enables population activity, rather than pairwise neuronal correlations, drive experience.

Язык: Английский

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Entorhinal cortex directs learning-related changes in CA1 representations

Nature, Год журнала: 2022, Номер 611(7936), С. 554 - 562

Опубликована: Ноя. 2, 2022

Abstract Learning-related changes in brain activity are thought to underlie adaptive behaviours 1,2 . For instance, the learning of a reward site by rodents requires development an over-representation that location hippocampus 3–6 How this learning-related change occurs remains unknown. Here we recorded hippocampal CA1 population as mice learned on linear treadmill. Physiological and pharmacological evidence suggests required behavioural timescale synaptic plasticity (BTSP) 7 BTSP is known be driven dendritic voltage signals proposed were initiated input from entorhinal cortex layer 3 (EC3). Accordingly, was largely removed optogenetic inhibition EC3 activity. Recordings neurons revealed pattern could provide instructive signal directing generate over-representation. Consistent with function, our observations show exposure second environment possessing prominent reward-predictive cue resulted both place field density more elevated at than reward. These data indicate produced directed seems specifically adapted behaviourally relevant features environment.

Язык: Английский

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Signatures of rapid plasticity in hippocampal CA1 representations during novel experiences

Neuron, Год журнала: 2022, Номер 110(12), С. 1978 - 1992.e6

Опубликована: Апрель 20, 2022

Язык: Английский

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Local feedback inhibition tightly controls rapid formation of hippocampal place fields

Neuron, Год журнала: 2022, Номер 110(5), С. 783 - 794.e6

Опубликована: Янв. 5, 2022

Язык: Английский

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Synaptic memory and CaMKII

Physiological Reviews, Год журнала: 2023, Номер 103(4), С. 2897 - 2945

Опубликована: Июнь 8, 2023

Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) and long-term potentiation (LTP) were discovered within a decade of each other have been inextricably intertwined ever since. However, like many marriages, it has had its up downs. Based on the unique biochemical properties CaMKII, was proposed as memory molecule before any physiological linkage made to LTP. reviewed here, convincing CaMKII synaptic physiology behavior took decades. New technologies critical in this journey, including vitro brain slices, mouse genetics, single-cell molecular pharmacological reagents, structure, two-photon microscopy, new investigators attracted by exciting challenge. This review tracks journey assesses state marriage 40 years on. The collective literature impels us propose relatively simple model for involving following steps that drive process: 1) entry through N-methyl-d-aspartate (NMDA) receptors activates CaMKII. 2) undergoes autophosphorylation resulting constitutive, -independent activity exposure binding site NMDA receptor subunit GluN2B. 3) Active translocates postsynaptic density (PSD) binds cytoplasmic C-tail 4) CaMKII-GluN2B complex initiates structural rearrangement PSD may involve liquid-liquid phase separation. 5) involves PSD-95 scaffolding protein, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPARs), their transmembrane AMPAR-regulatory (TARP) auxiliary subunits, an accumulation AMPARs underlies potentiation. 6) stability modified is maintained complex. 7) By process exchange or interholoenzyme phosphorylation maintains face turnover. There are important proteins participate enlargement spine modulation maintain In we critically discuss data underlying steps. As will become clear, some these more firmly grounded than others, provide suggestions how evidence supporting can be strengthened or, based data, replaced. Although long one, prospect having detailed cellular understanding learning at hand.

Язык: Английский

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Barcoding of episodic memories in the hippocampus of a food-caching bird

Cell, Год журнала: 2024, Номер 187(8), С. 1922 - 1935.e20

Опубликована: Март 29, 2024

Язык: Английский

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Universal statistics of hippocampal place fields across species and dimensionalities

Neuron, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Hippocampal place cells have single, bell-shaped fields in small environments. Recent experiments, however, reveal that, large environments, multiple with heterogeneous shapes and sizes. We show that this diversity is explained by a surprisingly simple mathematical model, which are generated thresholding realization of random Gaussian process. The model captures the statistics field arrangements generates new quantitative predictions about topologies. These quantitatively verified bats rodents, one, two, three dimensions, both results imply common mechanisms underlie diverse observed different experiments further suggest synaptic projections to CA1 predominantly random.

Язык: Английский

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Synaptic plasticity rules driving representational shifting in the hippocampus

Nature Neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Март 20, 2025

Язык: Английский

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Neurophysiology of Remembering

Annual Review of Psychology, Год журнала: 2021, Номер 73(1), С. 187 - 215

Опубликована: Сен. 18, 2021

By linking the past with future, our memories define sense of identity. Because human memory engages conscious realm, its examination has historically been approached from language and introspection proceeded largely along separate parallel paths in humans other animals. Here, we first highlight achievements limitations this mind-based approach make case for a new brain-based understanding declarative focus on hippocampal physiology. Next, discuss interleaved nature common physiological mechanisms navigation real mental spacetime. We suggest that distinguishing feature types is whether they subserve actions single or multiple uses. Finally, contrast to persisting view mind as highly plastic blank slate ready world imprint, hypothesize neuronal networks are endowed reservoir neural trajectories, challenge faced by brain how select match preexisting trajectories events world.

Язык: Английский

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