Top-down input modulates visual context processing through an interneuron-specific circuit

Cell Reports, Год журнала: 2023, Номер 42(9), С. 113133 - 113133

Опубликована: Сен. 1, 2023

Visual stimuli that deviate from the current context elicit augmented responses in primary visual cortex (V1). These heightened responses, known as "deviance detection," require local inhibition V1 and top-down input anterior cingulate area (ACa). Here, we investigated mechanisms by which ACa interact to support deviance detection. Local field potential recordings mice during an oddball paradigm showed ACa-V1 synchrony peaks theta/alpha band (≈10 Hz). Two-photon imaging revealed mainly pyramidal neurons exhibited detection, while contextually redundant increased vasoactive intestinal peptide (VIP)-positive interneuron (VIP) activity decreased somatostatin-positive (SST) activity. Optogenetic drive of inputs at 10 Hz activated V1-VIPs but inhibited V1-SSTs, mirroring dynamics present paradigm. Chemogenetic disrupted Aca-V1 detection V1. results outline temporal interneuron-specific modulation processing.

Язык: Английский

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Cooperative thalamocortical circuit mechanism for sensory prediction errors

Nature, Год журнала: 2024, Номер 633(8029), С. 398 - 406

Опубликована: Авг. 28, 2024

Abstract The brain functions as a prediction machine, utilizing an internal model of the world to anticipate sensations and outcomes our actions. Discrepancies between expected actual events, referred errors, are leveraged update guide attention towards unexpected events 1–10 . Despite importance prediction-error signals for various neural computations across brain, surprisingly little is known about circuit mechanisms responsible their implementation. Here we describe thalamocortical disinhibitory that required generating sensory in mouse primary visual cortex (V1). We show violating animals’ predictions by stimulus preferentially boosts responses layer 2/3 V1 neurons most selective stimulus. Prediction errors specifically amplify input, rather than representing non-specific surprise or difference how input deviates from animal’s predictions. This amplification implemented cooperative mechanism requiring thalamic pulvinar cortical vasoactive-intestinal-peptide-expressing (VIP) inhibitory interneurons. In response VIP inhibit specific subpopulation somatostatin-expressing interneurons gate excitatory V1, resulting pulvinar-driven stimulus-selective V1. Therefore, prioritizes unpredicted information selectively increasing salience features through synergistic interaction neocortical circuits.

Язык: Английский

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Mouse hippocampal CA1 VIP interneurons detect novelty in the environment and support recognition memory

Cell Reports, Год журнала: 2024, Номер 43(4), С. 114115 - 114115

Опубликована: Апрель 1, 2024

In the CA1 hippocampus, vasoactive intestinal polypeptide-expressing interneurons (VIP-INs) play a prominent role in disinhibitory circuit motifs. However, specific behavioral conditions that lead to disinhibition remain uncertain. To investigate relevance of VIP-IN activity, we employed wireless technologies allowing us monitor and manipulate their function freely behaving mice. Our findings reveal that, during spatial exploration new environments, VIP-INs hippocampal region become highly active, facilitating rapid encoding novel information. Remarkably, both pyramidal neurons (PNs) exhibit increased activity when encountering changes environment, including context- object-related alterations. Concurrently, somatostatin- parvalbumin-expressing inhibitory populations show an inverse relationship with PN revealing occurs on timescale seconds. Thus, VIP-IN-mediated may constitute crucial element novelty acquisition recognition memory.

Язык: Английский

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Neocortical somatostatin neuron diversity in cognition and learning

Trends in Neurosciences, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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VIP interneurons regulate cortical size tuning and visual perception

Cell Reports, Год журнала: 2023, Номер 42(9), С. 113088 - 113088

Опубликована: Сен. 1, 2023

Cortical circuit function is regulated by extensively interconnected, diverse populations of GABAergic interneurons that may play key roles in shaping operation according to behavioral context. A specialized population co-express vasoactive intestinal peptides (VIP-INs) are activated during arousal and innervate other INs pyramidal neurons (PNs). Although state-dependent modulation VIP-INs has been studied, their role regulating sensory processing less well understood. We examined the impact primary visual cortex awake behaving mice. Loss VIP-IN activity alters somatostatin-expressing (SST-INs) but not PNs. In contrast, reduced globally disrupts feature selectivity for stimulus size. Moreover, on perceptual behavior varies with context more acute small than large cues. thus contribute both cortical context-dependent performance.

Язык: Английский

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Somatostatin and the pathophysiology of Alzheimer’s disease

Ageing Research Reviews, Год журнала: 2024, Номер 96, С. 102270 - 102270

Опубликована: Март 13, 2024

Язык: Английский

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VIP interneurons in sensory cortex encode sensory and action signals but not direct reward signals

Current Biology, Год журнала: 2023, Номер 33(16), С. 3398 - 3408.e7

Опубликована: Июль 26, 2023

Vasoactive intestinal peptide (VIP) interneurons in sensory cortex modulate responses based on global exploratory behavior and arousal state, but their function during non-exploratory, goal-directed is not well understood. In particular, whether VIP cells are activated by cues, reward-seeking actions, or directly reinforcement unclear. We trained mice a Go/NoGo whisker touch detection task that included delay period other features designed to separate sensory-evoked, action-related, reward-related neural activity. Mice had lick response stimulus receive variable-sized reward. Using two-photon calcium imaging, we measured ΔF/F of L2/3 neurons somatosensory (S1) behavior. both expert novice mice, were strongly stimuli actions (licking), reinforcement. showed somatotopic tuning was spatially organized relative anatomical columns S1, unlike lick-related signals which widespread. suppressed, enhanced, when reward delivered, the amount suppression increased with size. This seen where delivery yoked licking. These results indicate besides state variables, local Instead, our consistent role for encoding expectation associated motor actions.

Язык: Английский

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Cooperative thalamocortical circuit mechanism for sensory prediction errors

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Июль 12, 2023

Abstract The brain functions as a prediction machine, utilizing an internal model of the world to anticipate sensations and outcomes our actions. Discrepancies between expected actual events, referred errors, are leveraged update guide attention towards unexpected events 1–10 . Despite importance error signals for various neural computations across multiple regions, surprisingly little is known about circuit mechanisms responsible their implementation. Here we describe thalamocortical disinhibitory required generating sensory errors in mouse primary visual cortex (V1). Using calcium imaging with optogenetic manipulations mice traverse familiar virtual environment, show that violation animals’ predictions by stimulus preferentially boosts responses layer 2/3 V1 neurons most selective stimulus. Prediction specifically amplify input, rather than representing non-specific surprise or difference signal how input deviates from predictions. Selective amplification implemented cooperative mechanism requiring thalamic pulvinar, cortical vasoactive-intestinal-peptide-expressing (VIP) inhibitory interneurons. In response VIP inhibit specific subpopulation somatostatin-expressing (SOM) interneurons gate excitatory pulvinar V1, resulting pulvinar-driven response-amplification stimulus-selective V1. Therefore, prioritizes unpredicted information selectively increasing salience features through synergistic interaction neocortical circuits.

Язык: Английский

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Acute alcohol and chronic drinking bidirectionally regulate the excitability of prefrontal cortex vasoactive intestinal peptide interneurons

Neuropharmacology, Год журнала: 2023, Номер 238, С. 109638 - 109638

Опубликована: Июль 22, 2023

Язык: Английский

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Intermittent fasting produces antidepressant-like effects by modulating dopamine D1 receptors in the medial prefrontal cortex

Neurobiology of Disease, Год журнала: 2025, Номер 211, С. 106931 - 106931

Опубликована: Апрель 30, 2025

Nutritional psychiatry has gained increasing attention, particularly in exploring dietary interventions for depression treatment. As a potential non-drug intervention, intermittent fasting (IF) gradually attracted the interest of researchers, but its specific neurobiological mechanisms remain unclear. The medial prefrontal cortex (mPFC) dopamine D1 receptors (Drd1) are significant stress response and serve as molecular target rapid-acting antidepressants. Our previous study indicated that 9-h produces an antidepressant-like effect by modulating (DA) receptors. However, whether IF effects through actions on DA receptor-mediated remains Here, we investigated improving depression-like behavior induced Chronic Unpredictable Mild Stress (CUMS) mice explored these regulated Drd1. We found alleviated CUMS-induced behavior, increased c-Fos expression mPFC hippocampus CUMS mice, activated Drd1-cAMP-PKA-DARPP-32-CREB-BDNF signaling pathway. were reversed Drd1 antagonist SCH23390. Additionally, optogenetic activation Drd1-expressing neurons improved while inhibition suppressed IF-induced effects. These findings imply plays crucial role offer valuable insights into application clinical

Язык: Английский

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