Vertex models capturing subcellular scales in epithelial tissues DOI Creative Commons
Zoë Lange, Franziska Matthäus, Mingfeng Qiu

и другие.

PLoS Computational Biology, Год журнала: 2025, Номер 21(5), С. e1012993 - e1012993

Опубликована: Май 21, 2025

Vertex models provide a robust theoretical framework for studying epithelial tissues as network of cell boundaries. They have been pivotal in exploring properties such packing geometry and rigidity transitions. Recently, extended vertex become instrumental bridging the subcellular scales to tissue scale. Here, we review extensions model aiming capture experimentally observed features including heterogeneity myosin activity across tissue, non-uniform contractility structures, mechanosensitive feedback loops. We discuss how these change challenge current perspectives on observables macroscopic properties. First, find that can significantly, impacting critical threshold some cases even existence transition. Second, disorder be explained by employing different mechanisms, indicating source stochasticity gradual local size changes common mesoscopic motifs mechanics organization. address complementary statistical inference, putting broader methodological context give brief overview software packages utilized increasingly complex studies. Our emphasizes need more comparative, systematic studies identify specific classes which share set well-defined properties, well in-depth discussion modeling choices their biological motivations.

Язык: Английский

Ductile-to-brittle transition and yielding in soft amorphous materials: perspectives and open questions DOI Creative Commons
Thibaut Divoux, Elisabeth Agoritsas, Stefano Aime

и другие.

Soft Matter, Год журнала: 2024, Номер 20(35), С. 6868 - 6888

Опубликована: Янв. 1, 2024

The manuscript offers a critical perspective on the shear-induced solid-to-liquid transition in amorphous materials, synthesizing insights from talks and informal discussions that unfolded during week of vibrant exchange at Lorentz Center.

Язык: Английский

Процитировано

14
Learning dynamical models of single and collective cell migration: a review DOI Creative Commons
David B. Brückner,

Chase P. Broedersz

Reports on Progress in Physics, Год журнала: 2024, Номер 87(5), С. 056601 - 056601

Опубликована: Март 22, 2024

Single and collective cell migration are fundamental processes critical for physiological phenomena ranging from embryonic development immune response to wound healing cancer metastasis. To understand a physical perspective, broad variety of models the underlying mechanisms that govern motility have been developed. A key challenge in such is how connect them experimental observations, which often exhibit complex stochastic behaviours. In this review, we discuss recent advances data-driven theoretical approaches directly with data infer dynamical migration. Leveraging nanofabrication, image analysis, tracking technology, studies now provide unprecedented large datasets on cellular dynamics. parallel, efforts directed towards integrating into single tissue scale aim conceptualising emergent behaviour cells. We first review inference problem has addressed both freely migrating confined Next, why these dynamics typically take form underdamped equations motion, can be inferred data. then applications machine learning heterogeneity behaviour, subcellular degrees freedom, multicellular systems. Across applications, emphasise methods integrated active matter cells, help reveal molecular control behaviour. Together, promising avenue building data, providing conceptual links between different length-scales description.

Язык: Английский

Процитировано

12
A geometric-tension-dynamics model of epithelial convergent extension DOI Creative Commons
Nikolas H Claussen, Fridtjof Brauns, Boris I. Shraiman

и другие.

Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(40)

Опубликована: Сен. 27, 2024

Convergent extension of epithelial tissue is a key motif animal morphogenesis. On coarse scale, cell motion resembles laminar fluid flow; yet in contrast to fluid, cells adhere each other and maintain the layer under actively generated internal tension. To resolve this apparent paradox, we formulate model which flow tension-dominated regime occurs through adiabatic remodeling force balance network adherens junctions. We propose that slow dynamics within manifold force-balanced configurations driven by positive feedback on myosin-generated cytoskeletal Shifting tension causes active rearrangements (T1 transitions) resulting net deformation oriented initial anisotropy. Strikingly, find total extent depends cellular packing order. T1s degrade order so self-limiting. explain these findings showing coordination coherence local configurations, quantified geometric parameter space. Our reproduces salient tissue- cell-scale features germ band elongation during Drosophila gastrulation, particular slowdown after approximately twofold concomitant with loss configurations. This suggests geometry contains morphogenetic information yields experimentally testable predictions. Defining biologically controlled states may provide general approach description flow.

Язык: Английский

Процитировано

12
Cell-Level Modelling of Homeostasis in Confined Epithelial Monolayers DOI Creative Commons

KVS Chaithanya,

Jan Rozman, Andrej Košmrlj

и другие.

Journal of Elasticity, Год журнала: 2025, Номер 157(2)

Опубликована: Фев. 24, 2025

Abstract Tissue homeostasis, the biological process of maintaining a steady state in tissue via control cell proliferation and death, is essential for development, growth, maintenance, proper function living organisms. Disruptions to this can lead serious diseases even death. In study, we use vertex model cell-level description mechanics investigate impact environment local mechanical properties cells on homeostasis confined epithelial tissues. We find dynamic state, where balance between divisions removals sustains characterise homeostatic terms count, area, pressure, cells’ neighbour count distribution. This work, therefore, sheds light mechanisms underlying highlights importance its control.

Язык: Английский

Процитировано

1
Self-aligning polar active matter DOI
Paul Baconnier, Olivier Dauchot, Vincent Démery

и другие.

Reviews of Modern Physics, Год журнала: 2025, Номер 97(1)

Опубликована: Март 20, 2025

Язык: Английский

Процитировано

1
Linear viscoelastic properties of the vertex model for epithelial tissues DOI Creative Commons

Sijie Tong,

Navreeta K. Singh,

Rastko Sknepnek

и другие.

PLoS Computational Biology, Год журнала: 2022, Номер 18(5), С. e1010135 - e1010135

Опубликована: Май 19, 2022

Epithelial tissues act as barriers and, therefore, must repair themselves, respond to environmental changes and grow without compromising their integrity. Consequently, they exhibit complex viscoelastic rheological behavior where constituent cells actively tune mechanical properties change the overall response of tissue, e.g., from solid-like fluid-like. Mesoscopic epithelia are commonly modeled with vertex model. While previous studies have predominantly focused on model at long time scales, we systematically studied full dynamic range by applying small oscillatory shear bulk deformations in both fluid-like phases for regular hexagonal disordered cell configurations. We found that responses fluid solid can be described standard spring-dashpot models. Furthermore, solid-fluid transition tuned pre-deformation system. Our study provides insights into mechanisms which regulate rich behavior.

Язык: Английский

Процитировано

39
A mechanochemical model recapitulates distinct vertebrate gastrulation modes DOI Creative Commons
Mattia Serra, Guillermo Serrano Nájera, Manli Chuai

и другие.

Science Advances, Год журнала: 2023, Номер 9(49)

Опубликована: Дек. 6, 2023

During vertebrate gastrulation, an embryo transforms from a layer of epithelial cells into multilayered gastrula. This process requires the coordinated movements hundreds to tens thousands cells, depending on organism. In chick embryo, patterns actomyosin cables spanning several drive tissue flows. Here, we derive minimal theoretical framework that couples activity global Our model predicts onset and development gastrulation flows in normal experimentally perturbed embryos, mimicking different modes as active stress instability. Varying initial conditions parameter associated with cell ingression, our recapitulates distinct morphologies, consistent recently published experiments embryo. Altogether, results show how changes patterning critical behaviors force-generating mechanisms contribute via self-organizing mechanochemical process.

Язык: Английский

Процитировано

20
Emergence, Pattern, and Frequency of Spontaneous Waves in Spreading Epithelial Monolayers DOI
Xu Yin, Yongquan Liu, Liyuan Zhang

и другие.

Nano Letters, Год журнала: 2024, Номер 24(12), С. 3631 - 3637

Опубликована: Март 11, 2024

A striking phenomenon of collective cell motion is that they can exhibit a spontaneously emerging wave during epithelia expansions. However, the fundamental mechanism, governing emergence and its crucial characteristics (e.g., eigenfrequency pattern), remains an enigma. By introducing mechanochemical feedback loop, we develop highly efficient discrete vertex model to investigate spatiotemporal evolution spreading epithelia. We find both numerically analytically expanding monolayers display power-law dependence frequency on local heterogeneities (i.e., density) with scaling exponent −1/2. Moreover, our study demonstrates quantitative capability proposed in capturing distinct X-, W-, V-mode patterns. unveil phase transition between these modes governed by distribution active self-propulsion forces. Our work provides avenue for rigorous investigations into pattern formation groups.

Язык: Английский

Процитировано

9
Vertex model with internal dissipation enables sustained flows DOI Creative Commons
Jan Rozman,

KVS Chaithanya,

Julia M. Yeomans

и другие.

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 9, 2025

Язык: Английский

Процитировано

1
Interplay between Mechanochemical Patterning and Glassy Dynamics in Cellular Monolayers DOI Creative Commons
Daniel Boocock, Tsuyoshi Hirashima, Édouard Hannezo

и другие.

PRX Life, Год журнала: 2023, Номер 1(1)

Опубликована: Июль 20, 2023

This article explores how the relative strength of chemical signaling and mechanical forces drive a transition from uniform active glass to periodic spatiotemporal waves, contributing comprehensive mechano-chemical theory tissue dynamics at different scales

Язык: Английский

Процитировано

15