bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown
Опубликована: Март 29, 2023
Collective motion emerges from individual interactions which produce groupwide patterns in behavior. While adaptive changes to collective are observed across animal species, how local change when these behaviors evolve is poorly understood. Here, we use the Mexican tetra,
Язык: Английский
Опубликована: Фев. 10, 2025
Dysregulation of sleep has widespread health consequences and represents an enormous burden. Short-sleeping individuals are predisposed to the effects neurodegeneration, suggesting a critical role for in maintenance neuronal health. While on cellular function not completely understood, growing evidence identified association between loss DNA damage, raising possibility that facilitates efficient repair. The Mexican tetra fish, Astyanax mexicanus provides model investigate evolutionary basis changes loss. Multiple cave-adapted populations these fish have evolved substantially less time compared surface same species without identifiable impacts healthspan or longevity. To whether is associated with damage stress, we Damage Response (DDR) oxidative stress levels A. populations. We measured markers chronic discovered elevated marker γH2AX brain, increased gut cavefish, consistent deprivation. Notably, found acute UV-induced elicited increase but cavefish. On transcriptional level, only activated photoreactivation repair pathway following UV damage. These findings suggest reduction DDR cavefish coincides examine pathways at created embryonic fibroblast cell line from two . observed both were diminished cells, corroborating vivo response lost long-term impact changes, transcriptome brain aged Strikingly, many genes differentially expressed young old do transcriptionally vary by age Taken together, developed resilience loss, despite possessing hallmarks
Язык: Английский
Процитировано
0
Integrative and Comparative Biology, Год журнала: 2023, Номер 63(2), С. 393 - 406
Опубликована: Май 22, 2023
Synopsis Reduction or complete loss of traits is a common occurrence throughout evolutionary history. In spite this, numerous questions remain about why and how trait has occurred. Cave animals are an excellent system in which these can be answered, as multiple traits, including eyes pigmentation, have been repeatedly reduced lost across populations cave species. This review focuses on the blind Mexican cavefish, Astyanax mexicanus, used model for examining developmental, genetic, mechanisms that underlie eye regression animals. We focus aspects evolved A. developmental genetic pathways contribute to regression, effects evolution other also forces contributing regression. discuss what known repeated both mexicanus cavefish more generally. Finally, we offer perspectives future further elucidate underlying using tools resources recently become available.
Язык: Английский
Процитировано
9
eLife, Год журнала: 2023, Номер 12
Опубликована: Июль 27, 2023
The vertebrate brain is highly conserved topologically, but less known about neuroanatomical variation between individual regions. Neuroanatomical at the regional level hypothesized to provide functional expansion, building upon ancestral anatomy needed for basic functions. Classically, animal models used study evolution have lacked tools detailed anatomical analysis that are widely in zebrafish and mice, presenting a barrier studying fine scales. In this study, we sought investigate of using single species fish consisting divergent surface cave morphs, permits genetic testing volume shape across entire brain. We generated high-resolution atlas blind Mexican cavefish Astyanax mexicanus coupled with automated computational directly assess variability region all populations. measured every grossly defined assessed correlations regions fish, cavefish, × F 2 hybrids, whose phenotypes span range cave. find dorsal contracted, while ventral expanded, hybrid data providing support developmental constraint along dorsal-ventral axis. Furthermore, these relationships show similar patterns both shape, suggesting captured by two parameters could be driven mechanisms. Together, demonstrate A. powerful system functionally determining principles will permit how genes influence early patterning events drive brain-wide evolution.
Язык: Английский
Процитировано
9
Ecology and Evolution, Год журнала: 2024, Номер 14(4)
Опубликована: Апрель 1, 2024
Abstract Cave‐adapted animals evolve a suite of regressive and constructive traits that allow survival in the dark. Most studies aiming at understanding cave animal evolution have focused on genetics environmental underpinnings traits, with special emphasis vision loss. Possibly as result loss, other non‐visual sensory systems expanded compensated species. For instance, many cave‐dwelling fish species, including blind cavefish Mexican tetra, Astyanax mexicanus , major mechanosensory system called lateral line, for loss through morphological expansions. While substantial work has shed light adaptation this system, there are still open questions regarding its developmental origin, synaptic plasticity, overall adaptive value. This review provides snapshot current state knowledge line adaption A. an anatomy, behavior. Multiple avenues future research how these can be leveraged tools both evolutionary biology medicine, discussed.
Язык: Английский
Процитировано
3
Springer eBooks, Год журнала: 2024, Номер unknown, С. 133 - 157
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
3
iScience, Год журнала: 2023, Номер 26(9), С. 107431 - 107431
Опубликована: Июль 20, 2023
Collective motion emerges from individual interactions which produce group-wide patterns in behavior. While adaptive changes to collective are observed across animal species, how local change when these behaviors evolve is poorly understood. Here, we use the Mexican tetra, Astyanax mexicanus, exists as a schooling surface form and non-schooling cave form, study differences fish alter their swimming response neighbors ontogeny between evolutionarily diverged populations. We find that undergo transition mediated by way modulate speed turning relative neighbors. This begins with tendency align emerging 28 days post-fertilization ends emergence of robust attraction 70 post-fertilization. Cavefish exhibit neither alignment nor at any stage development. These results reveal evolution alters striking
Язык: Английский
Процитировано
3
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Июль 25, 2024
Abstract Adaptive behaviors emerge in novel environments through functional changes neural circuits. While relationships between circuit function and behavior have been well studied, how evolution shapes those circuits leads to behavioral adpation is poorly understood. The Mexican cavefish , Astyanax mexicanus provides a unique genetically amendable model system, equipped with above ground eyed surface fish multiple evolutionarily divergent populations of blind that evolved complete darkness. These differences environment vision provide an opprotunity examine functionally influenced by the presence light. Here, we detection, response induced non visual light reception. Both exhibit photokinetic behavior, becoming hyperactive following sudden darkness illumination. To define these circuits, integrated whole brain imaging our atlas for responding changes. We identified caudal posterior tuberculum as central modulator both or dark stimulated photokinesis. unconver spatiotemporal neuronal activity differed cavefish, used stable pan-neuronal GCaMP transgenics show subpopulation sensitve neurons are now senstive cavefish. Further analysis revealed this integrative switch dependent on dopmane signaling, suggesting key role dopamine highly conserved modulating driving essential behavior. Together, data shed into adapte settings, reveal power elucidate mechanistic ingiths underlying sensory adaptation. Figure
Язык: Английский
Процитировано
0
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Дек. 15, 2024
Abstract Uncovering mechanisms by which sensory systems evolve is critical for understanding how organisms adapt to a novel environment. Astyanax mexicanus species of fish with populations surface that inhabit rivers and streams cavefish have adapted life within caves. Cavefish evolved system changes relative their counterparts, providing an opportunity investigate underlying evolution. Here, we report the role gene retinal homeobox 3 ( rx3 ) in eye We generated putative loss-of-function mutations using CRISPR-Cas9 determine this development species. These mutant fail develop eyes, demonstrating required development. Further, exhibit altered behaviors wild-type fish, suggesting loss eyes impacts sensory-dependent behaviors. Finally, cave-surface hybrid inherit allele from siblings allele, cis-regulatory variation at locus contributes size evolution cavefish. Together, these findings demonstrate that, as other species, A. . Moreover, they suggest plays reduction cavefish, shedding light on genetic response extreme environmental changes.
Язык: Английский
Процитировано
0
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown
Опубликована: Март 29, 2023
Collective motion emerges from individual interactions which produce groupwide patterns in behavior. While adaptive changes to collective are observed across animal species, how local change when these behaviors evolve is poorly understood. Here, we use the Mexican tetra,
Язык: Английский
Процитировано
0