bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Дек. 5, 2023
Perceptual
awareness
of
auditory
stimuli
decreases
from
wake-fulness
to
sleep,
largely
due
reduced
cortical
responsiveness.
During
wakefulness,
neural
responses
external
exhibit
a
broader
spatiotemporal
propagation
pattern
compared
deep
sleep.
A
potential
mechanism
for
this
phenomenon
is
the
synaptic
upscaling
excitatory
connections
during
as
posited
by
homeostasis
hypothesis.
However,
we
argue
that
uniform
alone
cannot
fully
account
observation.
We
propose
novel
suggesting
between
different
areas
exceeds
within
individual
wakefulness.
Our
computational
results
demonstrate
former
promotes
transfer
and
information,
whereas
latter
has
diminishing
effects.
These
findings
highlight
necessity
heterogeneous
suggest
presence
heterogeneity
in
receptor
expression
neuromodulators
involved
modulation
along
dendrite.
PLoS ONE,
Год журнала:
2023,
Номер
18(8), С. e0290146 - e0290146
Опубликована: Авг. 17, 2023
Neuronal
interactions
give
rise
to
complex
dynamics
in
cortical
networks,
often
described
terms
of
the
diversity
activity
patterns
observed
a
neural
signal.
Interestingly,
complexity
spontaneous
electroencephalographic
signals
decreases
during
slow-wave
sleep
(SWS);
however,
underlying
mechanisms
remain
elusive.
Here,
we
analyse
in-vivo
recordings
from
neocortical
and
hippocampal
neuronal
populations
rats
show
that
decrease
is
due
emergence
synchronous
DOWN
states.
Namely,
find
states
SWS
force
population
be
more
recurrent,
deterministic,
less
random
than
REM
or
wakefulness,
which,
turn,
leads
field
recordings.
Importantly,
when
exclude
analysis,
wakefulness
become
indistinguishable:
spiking
all
collapses
common
scaling.
We
complement
these
results
by
implementing
critical
branching
model
cortex,
which
shows
inducing
only
percentage
neurons
enough
generate
replicates
SWS.
Journal of Neurochemistry,
Год журнала:
2024,
Номер
169(1)
Опубликована: Дек. 16, 2024
Abstract
Preclinical
behavioral
testing
is
essential
for
drug
discovery
in
neuropsychiatric
disorders,
yet
translational
challenges
persist
because
of
interspecies
differences.
Touchscreen‐based
tasks
offer
a
promising
solution
bridging
this
gap.
These
provide
flexibility
across
cognitive
domains
and
species,
facilitating
rigorous
comparisons.
They
complement
traditional
assays,
offering
improved
face,
predictive,
construct
validity
by
mirroring
human
neuropsychological
tests.
Notably,
nearly
identical
have
been
validated
multiple
enhancing
potential.
Recent
studies
demonstrate
conserved
neurocircuitry
engagement
touchscreen
tasks,
supporting
their
relevance
to
function
therapeutic
development.
The
integration
electrophysiological
measures,
such
as
electroencephalography
(EEG)
local
field
potential
(LFP)
recordings
with
enhances
biomarker
serves
elucidate
neural
circuit
dynamics.
Despite
current
limitations
the
need
further
validation,
approach
offers
pathway
more
efficient
discovery.
This
review
covers
recent
research
describing
feasibility
benefits
EEG/LFP‐touchscreen
combination
rodents.
While
still
its
early
stages,
promise
strategy
evident.
Future
efforts
will
likely
focus
on
refining
methodologies,
identifying
robust
biomarkers,
expanding
species.
platforms,
integrated
measurements,
hold
significant
advance
our
understanding
disorders
accelerate
development
effective
treatments.
image
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Дек. 5, 2023
Perceptual
awareness
of
auditory
stimuli
decreases
from
wake-fulness
to
sleep,
largely
due
reduced
cortical
responsiveness.
During
wakefulness,
neural
responses
external
exhibit
a
broader
spatiotemporal
propagation
pattern
compared
deep
sleep.
A
potential
mechanism
for
this
phenomenon
is
the
synaptic
upscaling
excitatory
connections
during
as
posited
by
homeostasis
hypothesis.
However,
we
argue
that
uniform
alone
cannot
fully
account
observation.
We
propose
novel
suggesting
between
different
areas
exceeds
within
individual
wakefulness.
Our
computational
results
demonstrate
former
promotes
transfer
and
information,
whereas
latter
has
diminishing
effects.
These
findings
highlight
necessity
heterogeneous
suggest
presence
heterogeneity
in
receptor
expression
neuromodulators
involved
modulation
along
dendrite.
