Urologic Oncology Seminars and Original Investigations, Год журнала: 2023, Номер 42(4), С. 116.e17 - 116.e21
Опубликована: Дек. 11, 2023
Язык: Английский
Materials Advances, Год журнала: 2024, Номер 5(2), С. 475 - 503
Опубликована: Янв. 1, 2024
Graphical representation of the overview lung and oral cancer from detection to medical treatment.
Язык: Английский
Процитировано
17
The Lancet Oncology, Год журнала: 2023, Номер 24(8), С. 855 - 867
Опубликована: Авг. 1, 2023
Язык: Английский
Процитировано
39
European Journal of Clinical Investigation, Год журнала: 2023, Номер 53(8)
Опубликована: Апрель 17, 2023
Several teams have been publishing global estimates of excess deaths during the COVID-19 pandemic. Here, we examine potential flaws and underappreciated sources uncertainty in death calculations. Adjusting for changing population age structure is essential. Otherwise, are markedly overestimated countries with increasingly aging populations. changes other high-risk indicators, such as residence long-term facilities, may also make a difference. Death registration highly incomplete most countries; completeness corrections should allow substantial consider that changed pandemic years. Excess high sensitivity to modelling choice. Therefore different options be considered full range results shown choices pre-pandemic reference periods imposed models. Any post-modelling specific guided by pre-specified rules. Modelling all-cause mortality (ACM) ACM data extrapolating these models precarious; lack transportability. Existing underestimate overall multiplicative across diverse uncertainty. Informative require risk stratification, including groups ethnic/racial strata. Data to-date suggest deficit among children marked socioeconomic differences deaths, widening inequalities. Finally, causal explanations great caution disentangling SARS-CoV-2 indirect effects from measures taken. We conclude many uncertainties, but globally minority calculated deaths.
Язык: Английский
Процитировано
24
Scientific Reports, Год журнала: 2023, Номер 13(1)
Опубликована: Ноя. 24, 2023
Myeloma is one of the most common types haematological malignancies. We aimed to investigate incidence rates myeloma by sex, race, age, and histological subgroups in United States (US) over 2000-2020. Data were retrieved from Surveillance, Epidemiology, End Results (SEER) 22 database. The International Classification Diseases for Oncology version 3 morphological codes 9731, 9732, 9734 assigned solitary plasmacytoma bone, plasma cell myeloma, extraosseous plasmacytoma, respectively. Average annual percent change (AAPC) pairwise comparison with parallelism coincidence reported. All estimates reported as counts age-adjusted per 100,000 individuals. Over 2000-2019, cases among those aged at least 55 years (85.51%), men (54.82%), non-Hispanic Whites (66.67%). Among different subtypes, 193,530 had highest frequency same period. Also, there was a significant decrease age-standardized rate across all races/ethnicities both sexes within age groups (AAPC: - 8.02; 95% confidence interval (CI): 10.43 5.61) < 8.64; CI 11.02 6.25) 2019 November 2020. overall trends not parallel, nor identical. There an increase sexes, highly increasing rate, particularly younger Hispanic Black women 2000-2019. However, remarkable decline observed following COVID-19 pandemic
Язык: Английский
Процитировано
12
Archives of Public Health, Год журнала: 2024, Номер 82(1)
Опубликована: Июль 10, 2024
Laryngeal cancers account for one-third of all head and neck cancers. We aimed to report the incidence trends laryngeal cancer over 2000-2020 in United States (US), by age, sex, race/ethnicity, histological subtypes.
Язык: Английский
Процитировано
4
SSM - Health Systems, Год журнала: 2025, Номер unknown, С. 100050 - 100050
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
BMC Cancer, Год журнала: 2025, Номер 25(1)
Опубликована: Янв. 9, 2025
The COVID-19 pandemic involved business closures (e.g., gyms), social distancing policies, and prolonged stressful situations that may have impacted engagement in health behaviors. Our study assessed changes cancer-related behaviors during the pandemic, specifically physical activity, fruit/vegetable intake, smoking/tobacco use, alcohol consumption. Eight cancer centers administered mailed/web-based/telephone surveys between June 2020 March 2021. Surveys demographics, perceptions on distancing, self-reported of (less/same/more) associated with prevention or risk, e.g., tobacco/smoking Descriptive analyses logistic regression models association variables behavior change. Most 21,911 respondents reported adhering to at least 4(of 5) measures (72%) indicated was very/somewhat important prevent spread (91%). 35% less 11% 27% more use (among those who used products past 30 days), 23% consumption 1 drink days) than before pandemic. Urban residence, younger age, female gender, worse general were intake. Higher educational attainment activity intake Reporting as safety practices findings suggest certain demographics adhered likely self-report unfavorable Future studies should examine if returned baseline following relief from restrictions, these are increased incidence mortality.
Язык: Английский
Процитировано
0
Oncology nursing forum, Год журнала: 2025, Номер 52(2), С. 97 - 112
Опубликована: Фев. 18, 2025
The aims of this study were to characterize patients' distress, psychological symptoms, and resilience during the COVID-19 pandemic, evaluate differences in experiences, resilience, symptoms patients with without distress. Convergent parallel mixed-methods. Semistructured interviews structured questionnaires. Interview transcripts analyzed using content analysis. Differences demographic clinical characteristics, depression, anxiety, identified chi-square, Fisher's exact, independent sample t tests. Joint displays facilitated data integration meta-inferences. Of 54 patients, 25 who distressed more likely have low exhibit anxiety report difficulty paying their bills, identify as Hispanic. A patient-centered approach cancer care which clinicians assess psychological, social, economic resources make referrals supportive services is warranted.
Язык: Английский
Процитировано
0
Healthcare, Год журнала: 2025, Номер 13(7), С. 805 - 805
Опубликована: Апрель 3, 2025
Background/Objective: Gastrointestinal tract cancers may have been severely affected by the COVID-19 pandemic. The limitations of digestive endoscopy, fear effect, and restrictions on hospital admissions during pandemic delayed presentation patients to hospitals surgical procedures impacted overall survival. Methods: We conducted an observational, cross-sectional study esophageal, gastric, small bowel, colorectal cancer admitted our between 1 January 2018 31 December 2021. analyzed hospitalization rates, pathological type, onset complications, staging, surgery compared a pre-pandemic period (January 2018-December 2019). Results: During 2018-2021, 1613 with malignant gut tumors were (112 esophageal eso-cardial tumors, 419 gastric 34 bowel 1058 tumors). Admission was reduced 30.3% for 27.6% 17.3% tumors. For higher frequency stenosing palliative gastrostomies noted. More stage III lower rate vascular invasion recorded No differences regarding In slightly more II recorded, but occlusive, bleeding, perforated similar; also, rates similar, two-fold perioperative mortality. survival carcinoma (but no statistical significance), although clear explanation has not emerged. Conclusions: impact included significantly newly diagnosed admissions, carcinomas, mortality carcinoma, trend surprisingly without significance). Future research is necessary assessing long-term impact.
Язык: Английский
Процитировано
0
Journal of Evaluation in Clinical Practice, Год журнала: 2023, Номер 29(8), С. 1237 - 1239
Опубликована: Июнь 6, 2023
During the pandemic crisis of 2020–2023, it is likely that successes biomedical science were more than offset by its failures. These failures continue to undermine once-powerful ideals and hopes for science's role in societal betterment. Here, we dissect underpinnings these argue restoring such first requires systemic reform itself. The considerable medicine during COVID-19 pertained speed, example, real-time information sharing1, record-time development vaccines2, unprecedented rapidity getting results from some large randomized trials interventions3, solidly documenting or refuting claims effectiveness4. On this basis, visible scientists response seems worth celebrating. Basic research, translational research evidence-based tools all had bright days crisis. But success was accompanied major Some reflected efforts influential their political allies demonize dissenting scientific views evidence. From earliest pandemic, despite weak, absent contradictory evidence, leading national decision makers, facing urgent need action5, assured public they adopting policies 'following science'6. A new elite media-savvy experts fields like virology modelling (with without relevant credentials) gained visibility influence circles. narrow, reductionist disciplinary sometimes partisan perspectives7, 8 'influencers' helped justify allocated sacrifice, privation suffering across walks society hundreds millions lives. consequences education, healthcare, small businesses, social life democratic politics itself often disastrous. Consequences most acutely felt vulnerable populations, factory workers school children, old poor9. Radically different responses disease nation nation—from draconian lockdowns sectors, relatively permissive flexible regimes—made obvious value evidence support what politically desirable possible contexts. Rather following science, enlisted follow politics. Supposedly science-based turn built upon amplified deeper contradictions at intersections health. affluent nations with generously funded as United States Kingdom, been experiencing slow-downs even reversals gains expectancy predate COVID-1910, 11. trends, unthinkable 25 years ago, both reflect exacerbate pre-existing entrenched health inequities. For men London's neighbourhoods 18 longer those poor areas11. Such disparities have multiple causes, but economy medical a critical part story12. Investments sciences focus overwhelmingly on reductionist, molecular-genetic approaches cures, which can generate status profits companies, minimal benefits population may widen inequalities. Medical delivered through market mechanisms continually inflates healthcare costs, another driver Additional tensions science-health interface include misuse direct products itself, opioids, iatrogenic disorders. Indeed, lockdown, acquired new, dimensions13. Yet study communication disorders COVID too demonized high-level decision-makers advisors, clouded our ability openly debate balance impacts massive interventions imposed segments society. Now add uncertain plausible possibility product science14, 15, an apparently outrageous consequence becomes inescapable: become threat overall Under ambiguous circumstances, could feed into rising tide scepticism about authority affairs, given uneasy possibilities accumulating mentioned, hardly irrational increasing proportion dissatisfied wondering whether truth path healthier world must lie somewhere else within prestigious journals celebrities science–policy–communication interface16. At time when monopoly has never contested17, pretence 'the' be deployed processes decisions interest only make contestation worse. This not 'relativist' perspective, hard lesson COVID-19. Contradictions enterprise, uncertainties knowledge, limits accomplish, disagreement actions take, are real unavoidable. In absence strong and, worse, inhibition get better justification 'the settled' accurate unfavourable 'can harm response'), coupled unwillingness acknowledge uncertainties, nonscientists clearly sense there something fundamentally wrong response. public, behaviour, collectively responds reality. More less answer. Entanglement happened various degrees most, if all, countries. It resulted extreme COVID-19, China's prolonged zero strategy eventually abandoned unsustainable. Lack transparency makes difficult fathom exact depth failures, China enormous uncertainty eventual level other excess deaths18. Moreover, states, unclear how far-reaching future negative impact measures last frontiers mental chronic outcomes19-21. experience clear today's enterprise autonomous, self-correcting global good, component global, regional economies needs poorly aligned22-27. Commodification predicted half century ago28, 29, reached levels30. Systemic problems industrial-scale widely acknowledged insularity disciplines lack system thinking31 integration32; proliferation biased, conflicted low-quality divorced needs33; waste driven productivity rather accountability34; truly open discussions funds needs35. Can science–policy–public rift became so healed? To pursue goal, democracies will embrace, over long term, one moves away current commodification incentives objectives29, 36, 37, acknowledges between values, accepts specialized expertise—and especially danger hordes influencers made media38—for guiding challenges necessary step healing process would advocates recognize own complicity having supported emergence problems, doing embrace redesign. Absent commitments, should expect continued balkanization expertise truth, left hope societies discover sources cohesion coherence outside remit science. authors declare no conflicts interest. John P. A. Ioannidis Joachim Sturmberg members editorial board journal evaluation paper. There data attached contribution.
Язык: Английский
Процитировано
7