Divergent recruitment of developmentally defined neuronal ensembles supports memory dynamics

Science, Год журнала: 2024, Номер 385(6710)

Опубликована: Авг. 15, 2024

Memories are dynamic constructs whose properties change with time and experience. The biological mechanisms underpinning these dynamics remain elusive, particularly concerning how shifts in the composition of memory-encoding neuronal ensembles influence evolution a memory over time. By targeting developmentally distinct subpopulations principal neurons, we discovered that encoding resulted concurrent establishment multiple traces mouse hippocampus. Two were instantiated early- late-born neurons followed reactivation trajectories after encoding. divergent recruitment underpinned gradual reorganization modulated persistence plasticity across learning episodes. Thus, our findings reveal profound intricate relationships between ensemble progression memories

Язык: Английский

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Hippocampal Representational Drift Persists in a Stable Multisensory Virtual Environment

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Апрель 19, 2025

Abstract Experiments tracking hippocampal place cells in mice navigating the same real environment have found significant changes neural representations over days. However, there is currently a debate whether such “representational drift” serves an intrinsic function, as distinguishing similar experiences occurring at different times, or instead observed due to subtle differences sensory behavior. Here, we used experimental control offered by multisensory virtual reality (VR) system determine that behavior do not detectably change drift rate. We also excitability of individual was most predictive their representational subsequent days, with more excitable exhibiting less drift. These findings establish occurs even highly reproducible environments and highlight neuronal key factor long-term stability.

Язык: Английский

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Parallel processing of past and future memories through reactivation and synaptic plasticity mechanisms during sleep

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Апрель 28, 2025

Язык: Английский

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Extinction training suppresses activity of fear memory ensembles across the hippocampus and alters transcriptomes of fear-encoding cells

Neuropsychopharmacology, Год журнала: 2024, Номер unknown

Опубликована: Июнь 14, 2024

Язык: Английский

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NMDA receptors regulate the firing rate set point of hippocampal circuits without altering single-cell dynamics

Neuron, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Highlights•Hippocampal firing is actively regulated around a network-level set point•Blocking NMDARs reduces this point without impairing compensatory responses•Intrinsic plasticity of PV neurons mediates novel NMDAR function via eEF2K•NMDARs regulate E/I ratio and network affecting single-neuron driftSummaryUnderstanding how neuronal circuits stabilize their activity fundamental yet poorly understood aspect neuroscience. Here, we show that hippocampal properties, such as rate distribution dimensionality, are regulated, despite perturbations single-cell drift. Continuous inhibition N-methyl-D-aspartate receptors (NMDARs) ex vivo lowers the excitation/inhibition rates while preserving resilience to perturbations. This establishes new NMDAR-eEF2K signaling pathway. NMDARs' capacity modulate mediated by excitatory synapses intrinsic excitability parvalbumin-positive neurons, respectively. In behaving mice, continuous blockade in CA1 altering drift or triggering response. These findings expand beyond canonical role synaptic raise possibility some NMDAR-dependent behavioral effects unique regulation population points.Graphical abstract

Язык: Английский

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Representational drift in barrel cortex is receptive field dependent

Current Biology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Язык: Английский

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Interactions between memory and reward systems

Elsevier eBooks, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Язык: Английский

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