International Dental Journal, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 1, 2024
Periodontitis is a chronic and multifactorial inflammatory disease. However, existing medications often lack sufficient therapeutic effects. The aim to identify potential biomarkers efficient targets using Mendelian randomisation (MR) single-cell analysis.
Язык: Английский
International Immunopharmacology, Год журнала: 2024, Номер 144, С. 113642 - 113642
Опубликована: Ноя. 22, 2024
Язык: Английский
Процитировано
3
International Dental Journal, Год журнала: 2024, Номер unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
3
Journal of Multidisciplinary Healthcare, Год журнала: 2025, Номер Volume 18, С. 1053 - 1065
Опубликована: Фев. 1, 2025
Periodontitis and metabolic syndrome (MetS) are both linked to inflammation, but their association remains unclear. This study aimed explore the between periodontitis MetS prevalence evaluate its impact on prognosis of all-cause cardiovascular mortality in MetS. Data were obtained from National Health Nutrition Examination Survey (NHANES) database. Logistic regression analysis was used investigate MetS, while Cox applied assess periodontal status poor individuals with Furthermore, restricted cubic spline (RCS) performed linear nonlinear associations parameters, including attachment loss (AL) probing depth (PD), A total 9,270 included analysis. Individuals had a higher compared those without (OR=1.24, 95% CI: 1.08-1.43). revealed that associated an increased risk (HR=2.03, CI:1.40-2.92) (HR=2.32, CI:1.05-5.10) among RCS demonstrated AL prevalence, (P for nonlinearity < 0.05). However, PD linearly risks these outcomes overall is as well mortality.
Язык: Английский
Процитировано
0
Inflammation, Год журнала: 2025, Номер unknown
Опубликована: Фев. 27, 2025
Periodontitis is a chronic inflammatory disease characterized by inflammation of the periodontal soft tissues and loss alveolar bone. In oral environment, subgingival microorganisms salivary metabolites reflect host's health status. This study aimed to understand periodontitis severity progression rate analyzing microflora identify potential biomarkers. Fifty-three volunteers with stage II were graded using bone (%)/age index into two grades: 33 in grade A (< 0.25) 20 B (0.25–1.00). Using case–control study, simultaneously analyzed biomarkers associated periodontitis. The red complex, orange Campylobacter spp., uncultured Candidatus Saccharibacteria such as 5-Aminovaleric acid, N1-Acetylspermine showed significant positive correlation clinical parameters. Furthermore, we identified four differential (DL-Leucineamide, Dodecanedioic L-Tyrosine methyl ester Phenylpyruvic acid) that may serve for predicting progression. These results complex significantly correlated influenced changes metabolites. Additionally, indicating predominantly amino acid derivatives, confirming interactions between exacerbate development.
Язык: Английский
Процитировано
0
Mediators of Inflammation, Год журнала: 2025, Номер 2025(1)
Опубликована: Янв. 1, 2025
Background: Scoliosis is a condition that can have severe consequences for millions of individuals on an annual basis. Current research in this field increasingly focusing the role immune system development disease. However, precise relationship between immunity and scoliosis remains to be fully elucidated. Method: Our investigation involved comprehensive Mendelian randomization (MR) analysis explore potential causal cells scoliosis. The univariable MR encompassed 731 their with Cochran's Q test, leave-one-out MR-Egger intercept were used assess pleiotropy heterogeneity. We performed multivariable account confounding factors cells. colocalization summary data-based (SMR) utilized cis-eQTL. Results: study identified 13 significantly associated by MR, including four risk nine protective In order reduce cells, was employed, it determined only six cell types had independent effects SERPINH1 shared same variant CX3CR1 CD14- CD16-. FSD1L CCR2 SNHG14, SNORA33, NET1, SNORD100 HLA DR CD14+ CD16+ monocyte. Conclusion: findings suggested possible link found key genes cell, which provides new direction further research. specific underlying mechanisms require future experiments.
Язык: Английский
Процитировано
0
Odontology, Год журнала: 2025, Номер unknown
Опубликована: Апрель 13, 2025
Язык: Английский
Процитировано
0
Exploration, Год журнала: 2025, Номер unknown
Опубликована: Май 1, 2025
ABSTRACT The concept of the microbiota‐gut‐brain axis has witnessed significant advancements, and observational studies revealed dysbiosis in gut microbiota patients with brain tumors. causal relationship between tumors potential prognostic value are still unclear. Based on multiple Mendelian randomization analyses, this study confirms effects four microbes meningioma, seven pituitary tumor, eight glioma. Sherlock framework, identifies 103 meningioma‐related microbe‐related genes (MRGs), 40 tumor‐related MRGs, 63 glioma‐related MRGs expressed tissues. Almost all associated tumor grade prognosis. Lastly, model based machine learning established study, namely signature (MRS), could robustly predict prognosis glioma provide insights for immunotherapy benefits. This presents evidence tumors, which contributes to our understanding axis. prognosis, along prediction capacity MRS its association immunotherapy, provides support use as biomarkers evaluate treatment response
Язык: Английский
Процитировано
0
International Dental Journal, Год журнала: 2024, Номер unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
2
International Dental Journal, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 1, 2024
Periodontitis is a chronic and multifactorial inflammatory disease. However, existing medications often lack sufficient therapeutic effects. The aim to identify potential biomarkers efficient targets using Mendelian randomisation (MR) single-cell analysis.
Язык: Английский
Процитировано
1