Strategic stabilization of arousal boosts sustained attention DOI Creative Commons
Jan Willem de Gee, Zakir Mridha,

Marisa Hudson

и другие.

Current Biology, Год журнала: 2024, Номер 34(18), С. 4114 - 4128.e6

Опубликована: Авг. 15, 2024

Arousal and motivation interact to profoundly influence behavior. For example, experience tells us that we have some capacity control our arousal when appropriately motivated, such as staying awake while driving a motor vehicle. However, little is known about how jointly decision computations, including if animals, rodents, adapt their state needs. Here, developed show results from an auditory, feature-based, sustained-attention task with intermittently shifting utility. We use pupil size estimate across wide range of states apply tailored signal-detection theoretic, hazard function, accumulation-to-bound modeling approaches in large cohort mice. find pupil-linked utility both major impacts on multiple aspects performance. Although substantial fluctuations persist conditions, mice partially stabilize near intermediate optimal level high. Behavioral analyses elements behavior improve during high influences some, but not all, them. Specifically, the likelihood timescale sensory evidence accumulation quantity accumulated per time step attending. In sum, establish specific decision-computational signatures arousal, motivation, interaction attention. So doing, provide experimental analysis framework for studying self-regulation neurotypical brains diseases attention-deficit/hyperactivity disorder.

Язык: Английский

Decision-making dynamics are predicted by arousal and uninstructed movements DOI Creative Commons
Daniel R. Hulsey, Kevin Zumwalt, Luca Mazzucato

и другие.

Cell Reports, Год журнала: 2024, Номер 43(2), С. 113709 - 113709

Опубликована: Янв. 26, 2024

During sensory-guided behavior, an animal's decision-making dynamics unfold through sequences of distinct performance states, even while stimulus-reward contingencies remain static. Little is known about the factors that underlie these changes in task performance. We hypothesize can be predicted by externally observable measures, such as uninstructed movements and arousal. Here, using computational modeling visual auditory data from mice, we uncovered lawful relationships between transitions strategic states arousal movements. Using hidden Markov models applied to behavioral choices during sensory discrimination tasks, find animals fluctuate minutes-long optimal, sub-optimal, disengaged states. Optimal state epochs are intermediate levels, reduced variability, pupil diameter movement. Our results demonstrate behaviors predict optimal suggest mice regulate their

Язык: Английский

Процитировано

18
Ketamine rescues anhedonia by cell-type- and input-specific adaptations in the nucleus accumbens DOI Creative Commons

Federica Lucantonio,

Jacob Roeglin,

Shuwen Li

и другие.

Neuron, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

1
Decision-making dynamics are predicted by arousal and uninstructed movements DOI Creative Commons
Daniel R. Hulsey, Kevin Zumwalt, Luca Mazzucato

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Март 2, 2023

During sensory-guided behavior, an animal's decision-making dynamics unfold through sequences of distinct performance states, even while stimulus-reward contingencies remain static. Little is known about the factors that underlie these changes in task performance. We hypothesize can be predicted by externally observable measures, such as uninstructed movements and arousal. Here, combining behavioral experiments mice with computational modeling, we uncovered lawful relationships between transitions strategic states arousal movements. Using hidden Markov models applied to choices during sensory discrimination tasks, found animals fluctuate minutes-long optimal, sub-optimal disengaged states. Optimal state epochs were intermediate levels, reduced variability, pupil diameter, along variability face locomotion. Our results demonstrate behaviors predict optimal suggest regulate their

Язык: Английский

Процитировано

12
Knockout of 5-HT7 receptor in the mouse mildly modifies the structure and function of dorsal raphe neurons DOI

Agnieszka Kania,

Michał Kiełbiński, Marcin Siwiec

и другие.

Brain Research, Год журнала: 2025, Номер unknown, С. 149655 - 149655

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Strategic stabilization of arousal boosts sustained attention DOI Creative Commons
Jan Willem de Gee, Zakir Mridha,

Marisa Hudson

и другие.

Current Biology, Год журнала: 2024, Номер 34(18), С. 4114 - 4128.e6

Опубликована: Авг. 15, 2024

Arousal and motivation interact to profoundly influence behavior. For example, experience tells us that we have some capacity control our arousal when appropriately motivated, such as staying awake while driving a motor vehicle. However, little is known about how jointly decision computations, including if animals, rodents, adapt their state needs. Here, developed show results from an auditory, feature-based, sustained-attention task with intermittently shifting utility. We use pupil size estimate across wide range of states apply tailored signal-detection theoretic, hazard function, accumulation-to-bound modeling approaches in large cohort mice. find pupil-linked utility both major impacts on multiple aspects performance. Although substantial fluctuations persist conditions, mice partially stabilize near intermediate optimal level high. Behavioral analyses elements behavior improve during high influences some, but not all, them. Specifically, the likelihood timescale sensory evidence accumulation quantity accumulated per time step attending. In sum, establish specific decision-computational signatures arousal, motivation, interaction attention. So doing, provide experimental analysis framework for studying self-regulation neurotypical brains diseases attention-deficit/hyperactivity disorder.

Язык: Английский

Процитировано

1