Bilateral interactions of optic-flow sensitive neurons coordinate course control in flies DOI Creative Commons
Victoria O. Pokusaeva, Roshan Satapathy, Olga Symonova

и другие.

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Окт. 12, 2024

Abstract Animals rely on compensatory actions to maintain stability and navigate their environment efficiently. These depend global visual motion cues known as optic-flow. While the optomotor response has been traditional focus for studying optic-flow compensation in insects, its simplicity insufficient determine role of intricate processing network involved course control. Here, we reveal a series control behaviours Drosophila link them specific neural circuits. We show that bilateral electrical coupling optic-flow-sensitive neurons fly’s lobula plate are required proper This interaction works alongside chemical synapses within HS-H2 dynamics direction turning behaviours. Our findings how insects use navigation, assigning new functional significance suggesting previously unknown gap junctions non-linear operations.

Язык: Английский

Whole-brain annotation and multi-connectome cell typing of Drosophila DOI Creative Commons
Philipp Schlegel, Yijie Yin, Alexander Shakeel Bates

и другие.

Nature, Год журнала: 2024, Номер 634(8032), С. 139 - 152

Опубликована: Окт. 2, 2024

Язык: Английский

Процитировано

106
Motor neurons generate pose-targeted movements via proprioceptive sculpting DOI
Benjamin Gorko, Igor Siwanowicz,

Kari Close

и другие.

Nature, Год журнала: 2024, Номер 628(8008), С. 596 - 603

Опубликована: Март 20, 2024

Язык: Английский

Процитировано

21
Dendrite architecture determines mitochondrial distribution patterns in vivo DOI Creative Commons
Eavan J. Donovan, Anamika Agrawal, Nicole Liberman

и другие.

Cell Reports, Год журнала: 2024, Номер 43(5), С. 114190 - 114190

Опубликована: Май 1, 2024

Neuronal morphology influences synaptic connectivity and neuronal signal processing. However, it remains unclear how shape affects steady-state distributions of organelles like mitochondria. In this work, we investigated the link between mitochondrial transport dendrite branching patterns by combining mathematical modeling with in vivo measurements architecture, motility, localization Drosophila HS (horizontal system) neurons. our model, different forms morphological scaling rules—which set relative thicknesses parent daughter branches at each junction dendritic arbor motility to branch thickness—predict dramatically global patterns. We show that dendrites obey specific subset rules that, lead realistic distributions. Moreover, demonstrate activity does not affect or localization, indicating are hard-wired architecture neuron.

Язык: Английский

Процитировано

6
A competitive disinhibitory network for robust optic flow processing in Drosophila DOI Creative Commons
Mert Erginkaya, Tomás Cruz, Margarida Brotas

и другие.

Nature Neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
Infrequent strong connections constrain connectomic predictions of neuronal function DOI
Timothy A. Currier, Thomas R. Clandinin

Cell, Год журнала: 2025, Номер unknown

Опубликована: Июнь 1, 2025

Язык: Английский

Процитировано

0
Temperature cues are integrated in a flexible circadian neuropeptidergic feedback circuit to remodel sleep-wake patterns in flies DOI Creative Commons

Xin Yuan,

Hailiang Li, Fang Guo

и другие.

PLoS Biology, Год журнала: 2024, Номер 22(12), С. e3002918 - e3002918

Опубликована: Дек. 2, 2024

Organisms detect temperature signals through peripheral neurons, which relay them to central circadian networks drive adaptive behaviors. Despite recent advances in Drosophila research, how circuits integrate cues with regulate sleep/wake patterns remains unclear. In this study, we used the FlyWire brain electron microscopy connectome map neuronal connections, identifying lateral posterior neurons LPNs as key nodes for integrating information into network. receive input from both and temperature-sensing promoting sleep behavior. Through analysis, genetic manipulation, behavioral assays, demonstrated that LPNs, downstream of thermo-sensitive anterior cells (ACs), suppress activity-promoting dorsal LNds via AstC pathway, inducing Disrupting LPN-LNd communication either AstCR1 RNAi or an mutant significantly impairs heat-induced reduction evening activity peak. Conversely, optogenetic calcium imaging assays revealed cold-activated subsequently stimulate NPF-NPFR signaling, establishing a negative feedback loop. This mechanism limits LNd activation appropriate levels, thereby fine-tuning peak increase at lower temperatures. conclusion, our study constructed comprehensive centered on identified novel peptidergic circuit coordinates signals, offering new insights regulation .

Язык: Английский

Процитировано

2
Bilateral interactions of optic-flow sensitive neurons coordinate course control in flies DOI Creative Commons
Victoria O. Pokusaeva, Roshan Satapathy, Olga Symonova

и другие.

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Окт. 12, 2024

Abstract Animals rely on compensatory actions to maintain stability and navigate their environment efficiently. These depend global visual motion cues known as optic-flow. While the optomotor response has been traditional focus for studying optic-flow compensation in insects, its simplicity insufficient determine role of intricate processing network involved course control. Here, we reveal a series control behaviours Drosophila link them specific neural circuits. We show that bilateral electrical coupling optic-flow-sensitive neurons fly’s lobula plate are required proper This interaction works alongside chemical synapses within HS-H2 dynamics direction turning behaviours. Our findings how insects use navigation, assigning new functional significance suggesting previously unknown gap junctions non-linear operations.

Язык: Английский

Процитировано

1