Whole-brain annotation and multi-connectome cell typing of Drosophila
Nature,
Год журнала:
2024,
Номер
634(8032), С. 139 - 152
Опубликована: Окт. 2, 2024
Язык: Английский
Motor neurons generate pose-targeted movements via proprioceptive sculpting
Nature,
Год журнала:
2024,
Номер
628(8008), С. 596 - 603
Опубликована: Март 20, 2024
Язык: Английский
Dendrite architecture determines mitochondrial distribution patterns in vivo
Cell Reports,
Год журнала:
2024,
Номер
43(5), С. 114190 - 114190
Опубликована: Май 1, 2024
Neuronal
morphology
influences
synaptic
connectivity
and
neuronal
signal
processing.
However,
it
remains
unclear
how
shape
affects
steady-state
distributions
of
organelles
like
mitochondria.
In
this
work,
we
investigated
the
link
between
mitochondrial
transport
dendrite
branching
patterns
by
combining
mathematical
modeling
with
in
vivo
measurements
architecture,
motility,
localization
Drosophila
HS
(horizontal
system)
neurons.
our
model,
different
forms
morphological
scaling
rules—which
set
relative
thicknesses
parent
daughter
branches
at
each
junction
dendritic
arbor
motility
to
branch
thickness—predict
dramatically
global
patterns.
We
show
that
dendrites
obey
specific
subset
rules
that,
lead
realistic
distributions.
Moreover,
demonstrate
activity
does
not
affect
or
localization,
indicating
are
hard-wired
architecture
neuron.
Язык: Английский
A competitive disinhibitory network for robust optic flow processing in Drosophila
Nature Neuroscience,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 1, 2025
Язык: Английский
Infrequent strong connections constrain connectomic predictions of neuronal function
Cell,
Год журнала:
2025,
Номер
unknown
Опубликована: Июнь 1, 2025
Язык: Английский
Temperature cues are integrated in a flexible circadian neuropeptidergic feedback circuit to remodel sleep-wake patterns in flies
PLoS Biology,
Год журнала:
2024,
Номер
22(12), С. e3002918 - e3002918
Опубликована: Дек. 2, 2024
Organisms
detect
temperature
signals
through
peripheral
neurons,
which
relay
them
to
central
circadian
networks
drive
adaptive
behaviors.
Despite
recent
advances
in
Drosophila
research,
how
circuits
integrate
cues
with
regulate
sleep/wake
patterns
remains
unclear.
In
this
study,
we
used
the
FlyWire
brain
electron
microscopy
connectome
map
neuronal
connections,
identifying
lateral
posterior
neurons
LPNs
as
key
nodes
for
integrating
information
into
network.
receive
input
from
both
and
temperature-sensing
promoting
sleep
behavior.
Through
analysis,
genetic
manipulation,
behavioral
assays,
demonstrated
that
LPNs,
downstream
of
thermo-sensitive
anterior
cells
(ACs),
suppress
activity-promoting
dorsal
LNds
via
AstC
pathway,
inducing
Disrupting
LPN-LNd
communication
either
AstCR1
RNAi
or
an
mutant
significantly
impairs
heat-induced
reduction
evening
activity
peak.
Conversely,
optogenetic
calcium
imaging
assays
revealed
cold-activated
subsequently
stimulate
NPF-NPFR
signaling,
establishing
a
negative
feedback
loop.
This
mechanism
limits
LNd
activation
appropriate
levels,
thereby
fine-tuning
peak
increase
at
lower
temperatures.
conclusion,
our
study
constructed
comprehensive
centered
on
identified
novel
peptidergic
circuit
coordinates
signals,
offering
new
insights
regulation
.
Язык: Английский
Bilateral interactions of optic-flow sensitive neurons coordinate course control in flies
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Окт. 12, 2024
Abstract
Animals
rely
on
compensatory
actions
to
maintain
stability
and
navigate
their
environment
efficiently.
These
depend
global
visual
motion
cues
known
as
optic-flow.
While
the
optomotor
response
has
been
traditional
focus
for
studying
optic-flow
compensation
in
insects,
its
simplicity
insufficient
determine
role
of
intricate
processing
network
involved
course
control.
Here,
we
reveal
a
series
control
behaviours
Drosophila
link
them
specific
neural
circuits.
We
show
that
bilateral
electrical
coupling
optic-flow-sensitive
neurons
fly’s
lobula
plate
are
required
proper
This
interaction
works
alongside
chemical
synapses
within
HS-H2
dynamics
direction
turning
behaviours.
Our
findings
how
insects
use
navigation,
assigning
new
functional
significance
suggesting
previously
unknown
gap
junctions
non-linear
operations.
Язык: Английский