Tracking the neurodevelopmental trajectory of beta band oscillations with optically pumped magnetometer-based magnetoencephalography
eLife,
Год журнала:
2024,
Номер
13
Опубликована: Фев. 16, 2024
Neural
oscillations
mediate
the
coordination
of
activity
within
and
between
brain
networks,
supporting
cognition
behaviour.
How
these
processes
develop
throughout
childhood
is
not
only
an
important
neuroscientific
question
but
could
also
shed
light
on
mechanisms
underlying
neurological
psychiatric
disorders.
However,
measuring
neurodevelopmental
trajectory
has
been
hampered
by
confounds
from
instrumentation.
In
this
paper,
we
investigate
suitability
a
disruptive
new
imaging
platform
-
optically
pumped
magnetometer-based
magnetoencephalography
(OPM-MEG)
to
study
during
development.
We
show
how
unique
192-channel
OPM-MEG
device,
which
adaptable
head
size
robust
participant
movement,
can
be
used
collect
high-fidelity
electrophysiological
data
in
individuals
aged
2
34
years.
Data
were
collected
somatosensory
task,
measured
both
stimulus-induced
modulation
beta
sensory
cortex,
whole-brain
connectivity,
showing
that
modulate
significantly
with
age.
Moreover,
pan-spectral
bursts
drive
task-induced
modulation,
their
probability
occurrence
spectral
content
change
Our
results
offer
insights
into
developmental
provide
clear
evidence
ideal
for
studying
electrophysiology
neurodevelopment.
Язык: Английский
A Novel, Robust, and Portable Platform for Magnetoencephalography using Optically Pumped Magnetometers
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Март 11, 2024
ABSTRACT
Magnetoencephalography
(MEG)
measures
brain
function
via
assessment
of
magnetic
fields
generated
by
neural
currents.
Conventional
MEG
uses
superconducting
sensors,
which
place
significant
limitations
on
performance,
practicality,
and
deployment;
however,
the
field
has
been
revolutionised
in
recent
years
introduction
optically-pumped-magnetometers
(OPMs).
OPMs
enable
measurement
signal
without
cryogenics,
consequently
conception
‘OPM-MEG’
systems
ostensibly
allow
increased
sensitivity
resolution,
lifespan
compliance,
free
subject
movement,
lower
cost.
However,
OPM-MEG
remains
its
infancy
with
both
sensor
system
design.
Here,
we
report
a
new
design
miniaturised
integrated
electronic
control,
high
level
portability,
improved
dynamic
range
(arguably
biggest
limitation
existing
instrumentation).
We
show
that
this
produces
equivalent
when
compared
to
an
established
instrument;
specifically,
measuring
task-induced
beta-band,
gamma-band
evoked
neuro-electrical
responses,
source
localisations
from
two
were
highly
comparable
temporal
correlation
was
>0.7
at
individual
>0.9
for
groups.
Using
electromagnetic
phantom,
demonstrate
running
background
up
8
nT.
is
effective
gathering
data
during
movement
(including
sitting-to-standing
paradigm)
it
compatible
simultaneous
electroencephalography
(EEG
–
clinical
standard).
Finally,
portability
moving
between
laboratories.
Overall,
our
shown
be
step
forward
technology
offers
attractive
platform
next
generation
functional
medical
imaging.
Язык: Английский
Research on the Application of Silver Nanowire-Based Non-Magnetic Transparent Heating Films in SERF Magnetometers
Sensors,
Год журнала:
2025,
Номер
25(1), С. 234 - 234
Опубликована: Янв. 3, 2025
We
propose
a
non-magnetic
transparent
heating
film
based
on
silver
nanowires
(Ag-NWs)
for
application
in
spin-exchange
relaxation-free
(SERF)
magnetic
field
measurement
devices.
To
achieve
ultra-high
sensitivity
atomic
magnetometers,
the
atoms
within
alkali
metal
vapor
cell
must
be
maintained
stable
and
uniform
high-temperature
environment.
Ag-NWs,
as
conductive
material
with
exceptional
electrical
conductivity,
are
well
suited
this
application.
By
employing
high-frequency
AC
heating,
we
effectively
minimize
associated
noise.
The
experimental
results
demonstrate
that
proposed
film,
utilizing
surface
method,
can
temperatures
exceeding
140
°C,
which
is
sufficient
to
vaporize
atoms.
average
flux
coefficient
of
0.1143
nT/mA.
Typically,
current
increases,
larger
generated.
When
integrated
system
discussed
paper,
characteristic
mitigate
low-frequency
interference.
In
comparison
traditional
flexible
printed
circuits
(FPC),
Ag-NWs
exhibits
more
temperature
distribution.
This
magnetically
leveraging
enhances
magnetometry
presents
opportunities
use
chip-level
gyroscopes,
clocks,
various
other
Язык: Английский
Source Reconstruction Without an MRI using Optically Pumped Magnetometer based Magnetoencephalography
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 31, 2025
Abstract
Source
modelling
in
magnetoencephalography
(MEG)
maps
the
spatial
origins
of
electrophysiological
signals
brain.
Typically,
this
requires
an
anatomical
MRI
scan
subject’s
head,
from
which
a
model
neuromagnetic
field
(the
forward
model)
is
derived.
Wearable
MEG
–
based
on
optically
pumped
magnetometers
(OPMs)
enables
measurement
participants
who
struggle
to
cope
with
conventional
scanning
environments
(e.g.
children),
enabling
study
novel
cohorts.
However,
its
value
limited
if
still
required
for
source
modelling.
Here
we
describe
method
warping
template
MRIs
3D
structured-light
scans
generate
“pseudo-MRIs”.
We
apply
our
using
data
20
during
sensory
task,
measuring
induced
(beta
band)
responses
and
whole-brain
functional
connectivity.
Results
show
that
group
average
locations
peak
task-induced
beta
modulation
were
separated
by
2.75
mm,
when
comparing
real-
pseudo-MRI
approaches.
Group
averaged
time-frequency
spectra
also
highly
correlated
(Pearson
correlation
0.99)
as
connectome
matrices
(0.87),
global
connectivity
(0.98).
In
sum,
results
demonstrate
source-localized
OPM-MEG
data,
modelled
without
individual
can
be
similar.
This
will
useful
future
studies
where
capture
challenging.
Язык: Английский
Facilitating cognitive neuroscience research with 80-sensor optically pumped magnetometer magnetoencephalography (OPM-MEG)
NeuroImage,
Год журнала:
2025,
Номер
311, С. 121182 - 121182
Опубликована: Апрель 3, 2025
Язык: Английский
Demonstrating the need for long inter-stimulus intervals when studying the post-movement beta rebound following a simple button press
Frontiers in Neuroscience,
Год журнала:
2025,
Номер
19
Опубликована: Апрель 25, 2025
Voluntary
movements
reliably
elicit
event-related
synchronization
of
oscillatory
neuronal
rhythms
in
the
beta
(15-30
Hz)
range
immediately
following
movement
offset,
as
measured
by
magneto/electroencephalography
(M/EEG).
This
response
has
been
termed
post-movement
rebound
(PMBR).
While
early
work
on
PMBR
advocated
for
long
inter-stimulus
intervals
(ISIs)-arguing
that
might
persist
several
seconds-these
concerns
have
since
fallen
wayside,
with
many
recent
studies
employing
very
short
(<
5
s)
ISIs.
In
this
we
interrogated
sensor-level
MEG
time
courses
635
individuals
who
participated
a
cued
button-pressing
paradigm
part
Cambridge
Centre
Ageing
and
Neuroscience
(Cam-CAN)
project.
We
focussed
subset
trials
which
button
presses
were
separated
at
least
15
s
and,
using
curve
modeling
Bayesian
inference,
estimated
point
power
returned
to
baseline
levels.
show
takes
around
4-5
return
levels
movement.
These
results
important
implications
experimental
design.
The
is
ubiquitously
defined
relative
preceding
period;
argue
ISIs
preclude
true
estimation
turn,
accurate
magnitude.
recommend
future
targeting
use
6-7
s,
allowing
baseline,
plus
1-2
period
proper
estimation.
Further
needed
clarify
duration
context
different
sensorimotor
paradigms
clinical
populations.
Язык: Английский
The development of aperiodic and periodic resting-state power between early childhood and adulthood: New insights from optically pumped magnetometers
Developmental Cognitive Neuroscience,
Год журнала:
2024,
Номер
69, С. 101433 - 101433
Опубликована: Авг. 10, 2024
Neurophysiological
signals,
comprised
of
both
periodic
(e.g.,
oscillatory)
and
aperiodic
non-oscillatory)
activity,
undergo
complex
developmental
changes
between
childhood
adulthood.
With
much
the
existing
literature
primarily
focused
on
features
brain
function,
our
understanding
signals
is
still
in
its
infancy.
Here,
we
are
first
to
examine
age-related
(peak
frequency
power)
(slope
offset)
activity
using
optically
pumped
magnetometers
(OPMs),
a
new,
wearable
magnetoencephalography
(MEG)
technology
that
particularly
well-suited
for
studying
development.
We
examined
these
spectral
sample
(N=65)
toddlers
(1-3
years),
children
(4-5
young
adults
(20-26
(27-38
years).
Consistent
with
extant
literature,
found
significant
decreases
slope
offset,
peak
power
were
frequency-specific;
show
effect
sizes
also
varied
across
regions.
This
work
not
only
adds
growing
body
highlighting
advantages
OPMs,
especially
development,
but
contributes
novel
information
regarding
variation
neurophysiological
age
brain.
Язык: Английский
A Novel Time–Frequency Parameterization Method for Oscillations in Specific Frequency Bands and Its Application on OPM-MEG
Bioengineering,
Год журнала:
2024,
Номер
11(8), С. 773 - 773
Опубликована: Июль 31, 2024
Time-frequency
parameterization
for
oscillations
in
specific
frequency
bands
reflects
the
dynamic
changes
brain.
It
is
related
to
cognitive
behavior
and
diseases
has
received
significant
attention
neuroscience.
However,
many
studies
do
not
consider
impact
of
aperiodic
noise
neural
activity,
including
their
time-varying
fluctuations.
Some
are
limited
by
low
resolution
time-frequency
spectrum
parameter-solved
operation.
Therefore,
this
paper
proposes
super-resolution
periodic
(transient)
oscillation
(STPPTO).
STPPTO
obtains
a
with
Superlet
transform.
Then,
representation
obtained
removing
component
fitted
time-resolved
way.
Finally,
definition
transient
events
used
parameterize
oscillations.
The
performance
method
validated
on
simulated
data
its
reliability
demonstrated
magnetoencephalography.
We
show
how
it
can
be
explore
analyze
oscillatory
activity
under
rhythmic
stimulation.
Язык: Английский
The development of aperiodic and periodic resting-state power between early childhood and adulthood: new insights from optically pumped magnetometers
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Май 14, 2024
Abstract
Neurophysiological
signals,
comprised
of
both
periodic
(e.g.,
oscillatory)
and
aperiodic
non-oscillatory)
activity,
undergo
complex
developmental
changes
between
childhood
adulthood.
With
much
the
existing
literature
primarily
focused
on
features
brain
function,
our
understanding
signals
is
still
in
its
infancy.
Here,
we
are
first
to
examine
age-related
(peak
frequency
power)
(slope
offset)
activity
using
optically
pumped
magnetometers
(OPMs),
a
new,
wearable
magnetoencephalography
(MEG)
technology
that
particularly
well-suited
for
studying
development.
We
examined
these
spectral
sample
(
N
=65)
toddlers
(1-3
years),
children
(4-5
young
adults
(20-26
(27-38
years).
Consistent
with
extant
literature,
found
significant
decreases
slope
offset,
peak
power
were
frequency-specific;
show
effect
sizes
also
varied
across
regions.
This
work
not
only
adds
growing
body
highlighting
advantages
OPMs,
especially
development,
but
contributes
novel
information
regarding
variation
neurophysiological
age
brain.
Язык: Английский