The development of aperiodic and periodic resting-state power between early childhood and adulthood: new insights from optically pumped magnetometers DOI Creative Commons
Marlee M. Vandewouw, Julie Sato, Kristina Safar

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 14, 2024

Abstract Neurophysiological signals, comprised of both periodic (e.g., oscillatory) and aperiodic non-oscillatory) activity, undergo complex developmental changes between childhood adulthood. With much the existing literature primarily focused on features brain function, our understanding signals is still in its infancy. Here, we are first to examine age-related (peak frequency power) (slope offset) activity using optically pumped magnetometers (OPMs), a new, wearable magnetoencephalography (MEG) technology that particularly well-suited for studying development. We examined these spectral sample ( N =65) toddlers (1-3 years), children (4-5 young adults (20-26 (27-38 years). Consistent with extant literature, found significant decreases slope offset, peak power were frequency-specific; show effect sizes also varied across regions. This work not only adds growing body highlighting advantages OPMs, especially development, but contributes novel information regarding variation neurophysiological age brain.

Language: Английский

Tracking the neurodevelopmental trajectory of beta band oscillations with optically pumped magnetometer-based magnetoencephalography DOI Creative Commons
Lukas Rier, Natalie Rhodes, Daisie Pakenham

et al.

eLife, Journal Year: 2024, Volume and Issue: 13

Published: Feb. 16, 2024

Neural oscillations mediate the coordination of activity within and between brain networks, supporting cognition behaviour. How these processes develop throughout childhood is not only an important neuroscientific question but could also shed light on mechanisms underlying neurological psychiatric disorders. However, measuring neurodevelopmental trajectory has been hampered by confounds from instrumentation. In this paper, we investigate suitability a disruptive new imaging platform - optically pumped magnetometer-based magnetoencephalography (OPM-MEG) to study during development. We show how unique 192-channel OPM-MEG device, which adaptable head size robust participant movement, can be used collect high-fidelity electrophysiological data in individuals aged 2 34 years. Data were collected somatosensory task, measured both stimulus-induced modulation beta sensory cortex, whole-brain connectivity, showing that modulate significantly with age. Moreover, pan-spectral bursts drive task-induced modulation, their probability occurrence spectral content change Our results offer insights into developmental provide clear evidence ideal for studying electrophysiology neurodevelopment.

Language: Английский

Citations

9
A Novel, Robust, and Portable Platform for Magnetoencephalography using Optically Pumped Magnetometers DOI Creative Commons
Holly Schofield, Ryan M. Hill, Odile Feys

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: March 11, 2024

ABSTRACT Magnetoencephalography (MEG) measures brain function via assessment of magnetic fields generated by neural currents. Conventional MEG uses superconducting sensors, which place significant limitations on performance, practicality, and deployment; however, the field has been revolutionised in recent years introduction optically-pumped-magnetometers (OPMs). OPMs enable measurement signal without cryogenics, consequently conception ‘OPM-MEG’ systems ostensibly allow increased sensitivity resolution, lifespan compliance, free subject movement, lower cost. However, OPM-MEG remains its infancy with both sensor system design. Here, we report a new design miniaturised integrated electronic control, high level portability, improved dynamic range (arguably biggest limitation existing instrumentation). We show that this produces equivalent when compared to an established instrument; specifically, measuring task-induced beta-band, gamma-band evoked neuro-electrical responses, source localisations from two were highly comparable temporal correlation was >0.7 at individual >0.9 for groups. Using electromagnetic phantom, demonstrate running background up 8 nT. is effective gathering data during movement (including sitting-to-standing paradigm) it compatible simultaneous electroencephalography (EEG – clinical standard). Finally, portability moving between laboratories. Overall, our shown be step forward technology offers attractive platform next generation functional medical imaging.

Language: Английский

Citations

3
Research on the Application of Silver Nanowire-Based Non-Magnetic Transparent Heating Films in SERF Magnetometers DOI Creative Commons

Ge Yi,

Yuhan Li, Yang Li

et al.

Sensors, Journal Year: 2025, Volume and Issue: 25(1), P. 234 - 234

Published: Jan. 3, 2025

We propose a non-magnetic transparent heating film based on silver nanowires (Ag-NWs) for application in spin-exchange relaxation-free (SERF) magnetic field measurement devices. To achieve ultra-high sensitivity atomic magnetometers, the atoms within alkali metal vapor cell must be maintained stable and uniform high-temperature environment. Ag-NWs, as conductive material with exceptional electrical conductivity, are well suited this application. By employing high-frequency AC heating, we effectively minimize associated noise. The experimental results demonstrate that proposed film, utilizing surface method, can temperatures exceeding 140 °C, which is sufficient to vaporize atoms. average flux coefficient of 0.1143 nT/mA. Typically, current increases, larger generated. When integrated system discussed paper, characteristic mitigate low-frequency interference. In comparison traditional flexible printed circuits (FPC), Ag-NWs exhibits more temperature distribution. This magnetically leveraging enhances magnetometry presents opportunities use chip-level gyroscopes, clocks, various other

Language: Английский

Citations

0
Source Reconstruction Without an MRI using Optically Pumped Magnetometer based Magnetoencephalography DOI Creative Commons
Natalie Rhodes, Lukas Rier, Elena Boto

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Abstract Source modelling in magnetoencephalography (MEG) maps the spatial origins of electrophysiological signals brain. Typically, this requires an anatomical MRI scan subject’s head, from which a model neuromagnetic field (the forward model) is derived. Wearable MEG – based on optically pumped magnetometers (OPMs) enables measurement participants who struggle to cope with conventional scanning environments (e.g. children), enabling study novel cohorts. However, its value limited if still required for source modelling. Here we describe method warping template MRIs 3D structured-light scans generate “pseudo-MRIs”. We apply our using data 20 during sensory task, measuring induced (beta band) responses and whole-brain functional connectivity. Results show that group average locations peak task-induced beta modulation were separated by 2.75 mm, when comparing real- pseudo-MRI approaches. Group averaged time-frequency spectra also highly correlated (Pearson correlation 0.99) as connectome matrices (0.87), global connectivity (0.98). In sum, results demonstrate source-localized OPM-MEG data, modelled without individual can be similar. This will useful future studies where capture challenging.

Language: Английский

Citations

0
Facilitating cognitive neuroscience research with 80-sensor optically pumped magnetometer magnetoencephalography (OPM-MEG) DOI Creative Commons
Wei Xu, Pan Liao, Miao Cao

et al.

NeuroImage, Journal Year: 2025, Volume and Issue: 311, P. 121182 - 121182

Published: April 3, 2025

Language: Английский

Citations

0
Demonstrating the need for long inter-stimulus intervals when studying the post-movement beta rebound following a simple button press DOI Creative Commons
Lyam M. Bailey,

Timothy Bardouille

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: April 25, 2025

Voluntary movements reliably elicit event-related synchronization of oscillatory neuronal rhythms in the beta (15-30 Hz) range immediately following movement offset, as measured by magneto/electroencephalography (M/EEG). This response has been termed post-movement rebound (PMBR). While early work on PMBR advocated for long inter-stimulus intervals (ISIs)-arguing that might persist several seconds-these concerns have since fallen wayside, with many recent studies employing very short (< 5 s) ISIs. In this we interrogated sensor-level MEG time courses 635 individuals who participated a cued button-pressing paradigm part Cambridge Centre Ageing and Neuroscience (Cam-CAN) project. We focussed subset trials which button presses were separated at least 15 s and, using curve modeling Bayesian inference, estimated point power returned to baseline levels. show takes around 4-5 return levels movement. These results important implications experimental design. The is ubiquitously defined relative preceding period; argue ISIs preclude true estimation turn, accurate magnitude. recommend future targeting use 6-7 s, allowing baseline, plus 1-2 period proper estimation. Further needed clarify duration context different sensorimotor paradigms clinical populations.

Language: Английский

Citations

0
The development of aperiodic and periodic resting-state power between early childhood and adulthood: New insights from optically pumped magnetometers DOI Creative Commons
Marlee M. Vandewouw, Julie Sato, Kristina Safar

et al.

Developmental Cognitive Neuroscience, Journal Year: 2024, Volume and Issue: 69, P. 101433 - 101433

Published: Aug. 10, 2024

Neurophysiological signals, comprised of both periodic (e.g., oscillatory) and aperiodic non-oscillatory) activity, undergo complex developmental changes between childhood adulthood. With much the existing literature primarily focused on features brain function, our understanding signals is still in its infancy. Here, we are first to examine age-related (peak frequency power) (slope offset) activity using optically pumped magnetometers (OPMs), a new, wearable magnetoencephalography (MEG) technology that particularly well-suited for studying development. We examined these spectral sample (N=65) toddlers (1-3 years), children (4-5 young adults (20-26 (27-38 years). Consistent with extant literature, found significant decreases slope offset, peak power were frequency-specific; show effect sizes also varied across regions. This work not only adds growing body highlighting advantages OPMs, especially development, but contributes novel information regarding variation neurophysiological age brain.

Language: Английский

Citations

2
A Novel Time–Frequency Parameterization Method for Oscillations in Specific Frequency Bands and Its Application on OPM-MEG DOI Creative Commons
Xiaoyu Liang, Ruonan Wang, Huanqi Wu

et al.

Bioengineering, Journal Year: 2024, Volume and Issue: 11(8), P. 773 - 773

Published: July 31, 2024

Time-frequency parameterization for oscillations in specific frequency bands reflects the dynamic changes brain. It is related to cognitive behavior and diseases has received significant attention neuroscience. However, many studies do not consider impact of aperiodic noise neural activity, including their time-varying fluctuations. Some are limited by low resolution time-frequency spectrum parameter-solved operation. Therefore, this paper proposes super-resolution periodic (transient) oscillation (STPPTO). STPPTO obtains a with Superlet transform. Then, representation obtained removing component fitted time-resolved way. Finally, definition transient events used parameterize oscillations. The performance method validated on simulated data its reliability demonstrated magnetoencephalography. We show how it can be explore analyze oscillatory activity under rhythmic stimulation.

Language: Английский

Citations

1
The development of aperiodic and periodic resting-state power between early childhood and adulthood: new insights from optically pumped magnetometers DOI Creative Commons
Marlee M. Vandewouw, Julie Sato, Kristina Safar

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 14, 2024

Abstract Neurophysiological signals, comprised of both periodic (e.g., oscillatory) and aperiodic non-oscillatory) activity, undergo complex developmental changes between childhood adulthood. With much the existing literature primarily focused on features brain function, our understanding signals is still in its infancy. Here, we are first to examine age-related (peak frequency power) (slope offset) activity using optically pumped magnetometers (OPMs), a new, wearable magnetoencephalography (MEG) technology that particularly well-suited for studying development. We examined these spectral sample ( N =65) toddlers (1-3 years), children (4-5 young adults (20-26 (27-38 years). Consistent with extant literature, found significant decreases slope offset, peak power were frequency-specific; show effect sizes also varied across regions. This work not only adds growing body highlighting advantages OPMs, especially development, but contributes novel information regarding variation neurophysiological age brain.

Language: Английский

Citations

0