Diagnosis of Obesity: 2022 Update of Clinical Practice Guidelines for Obesity by the Korean Society for the Study of Obesity

Journal of Obesity & Metabolic Syndrome, Год журнала: 2023, Номер 32(2), С. 121 - 129

Опубликована: Июнь 30, 2023

Ji-Hee Haam, Bom Taeck Kim, Eun Mi Hyuktae Kwon, Jee-Hyun Kang, Jung Hwan Park, Kyoung-Kon Sang Youl Rhee, Yang-Hyun Ki Young Lee. J Obes Metab Syndr 2023;32:121-9. https://doi.org/10.7570/jomes23031

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2023 Obesity Fact Sheet: Prevalence of Obesity and Abdominal Obesity in Adults, Adolescents, and Children in Korea from 2012 to 2021

Journal of Obesity & Metabolic Syndrome, Год журнала: 2024, Номер 33(1), С. 27 - 35

Опубликована: Март 27, 2024

The 2023 Obesity Fact Sheet aims to present an updated overview of obesity prevalence across all age groups, including children and adolescents.

Язык: Английский

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An overview of obesity‐related complications: The epidemiological evidence linking body weight and other markers of obesity to adverse health outcomes

Diabetes Obesity and Metabolism, Год журнала: 2025, Номер unknown

Опубликована: Март 11, 2025

Abstract Obesity is a highly prevalent chronic multisystem disease associated with shortened life expectancy due to number of adverse health outcomes. Epidemiological data link body weight and parameters central fat distribution an increasing risk for type 2 diabetes, hypertension, fatty liver diseases, cardiovascular diseases including myocardial infarction, heart failure, atrial fibrillation, stroke, obstructive sleep apnoea, osteoarthritis, mental disorders some types cancer. However, the individual develop cardiometabolic other obesity‐related cannot entirely be explained by increased mass. Rather than excess accumulation, dysfunction adipose tissue may represent mechanistic between obesity There are people living who seem protected against premature development diseases. On hand, normal typical upon predominantly visceral distribution. The mechanisms linking impaired function in include adipocyte hypertrophy, altered cellular composition, limited expandability safe subcutaneous stores, ectopic deposition depots, organs, hypoxia, variety stresses, inflammatory processes, release pro‐inflammatory, diabetogenic atherogenic signals. Genetic environmental factors might contribute either alone or via interaction intrinsic biological variation function. still many open questions regarding how causes whether these pathologies could reversed. Evidence‐based loss interventions using behaviour change, pharmacological surgical approaches have clarified beneficial effects realistic sustained on complications as hard This review focusses recent advances understanding epidemiological trends Plain Language Summary complex progressive characterized excessive that impair quality life. Worldwide, adults has more doubled since 1990. lead reduced expectancy, because it increases (e.g., high blood pressure, stroke), musculoskeletal respiratory depression certain not every person develops For better prevention treatment, important understand mass related It become clear explain higher complications. People can low developing Compared those abdominal region, average bigger cells, immune cells signals released from directly affect brain, liver, vasculature organs. Both inherited environment cause abnormalities through changes lower calorie intake, physical activity), medications surgery improve health, reduce

Язык: Английский

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Approved Anti-Obesity Medications in 2022 KSSO Guidelines and the Promise of Phase 3 Clinical Trials: Anti-Obesity Drugs in the Sky and on the Horizon

Journal of Obesity & Metabolic Syndrome, Год журнала: 2023, Номер 32(2), С. 106 - 120

Опубликована: Июнь 23, 2023

Obesity is a prevalent global health issue affecting approximately half of the world's population.Extensive scientific research highlights urgent need for effective obesity management to mitigate risks and prevent complications.While bariatric surgery has proven be highly effective, providing substantial short-term long-term weight loss resolution obesity-related comorbidities, it important recognize its limitations associated risks.Given epidemic surgical interventions, there high demand safe anti-obesity medications (AOMs).In Korea, Korean Society Study strongly advocates use pharmacotherapy in adults with body mass index 25 kg/m² or higher who have not achieved reduction through non-pharmacological treatments.Currently, five AOMs been approved management: orlistat, naltrexone/bupropion, phentermine/topiramate, liraglutide, semaglutide.Tirzepatide awaiting approval, compounds such as CagriSema (Novo Nordisk) oral semaglutide are currently undergoing rigorous evaluation phase 3 clinical trials.Furthermore, other promising drugs, including orforglipron, BI 456906, retartrutide, progressing studies, expanding therapeutic options management.In personalized patient care, physicians play crucial role accurately identifying individuals genuinely require selecting appropriate based on individual characteristics.By integrating evidence-based interventions considering unique needs patients, healthcare professionals significantly contribute success strategies.

Язык: Английский

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Obesity in Children and Adolescents: 2022 Update of Clinical Practice Guidelines for Obesity by the Korean Society for the Study of Obesity

Journal of Obesity & Metabolic Syndrome, Год журнала: 2024, Номер 33(1), С. 11 - 19

Опубликована: Янв. 9, 2024

Eungu Kang, Yong Hee Hong, Jaehyun Kim, Sochung Chung, Kyoung-Kon Ji-Hee Haam, Bom Taeck Eun Mi Jung Hwan Park, Sang Youl Rhee, Jee-Hyun Young-Jun Rhie. J Obes Metab Syndr -0001;0:0-. https://doi.org/10.7570/jomes23060

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A 12-Week, Single-Centre, Randomised, Double-Blind, Placebo-Controlled, Parallel-Design Clinical Trial for the Evaluation of the Efficacy and Safety of Lactiplantibacillus plantarum SKO-001 in Reducing Body Fat

Nutrients, Год журнала: 2024, Номер 16(8), С. 1137 - 1137

Опубликована: Апрель 11, 2024

There is growing evidence linking gut microbiota to overall health, including obesity risk and associated diseases. Lactiplantibacillus plantarum SKO-001, a probiotic strain isolated from Angelica gigas, has been reported reduce by controlling the microbiome. In this double-blind, randomised clinical trial, we aimed evaluate efficacy safety of SKO-001 in reducing body fat. We included 100 participants into or placebo groups (1:1) for 12 weeks. Dual-energy X-ray absorptiometry was used objectively fat reduction. Body percentage (p = 0.016), mass 0.02), low-density lipoprotein-cholesterol levels 0.025), adiponectin 0.023) were lower group than after weeks consumption. group, subcutaneous area 0.003), total cholesterol leptin 0.014) significantly decreased consumption compared with baseline values. Additionally, did not cause any severe adverse reactions. conclusion, safe effective potential further testing humans.

Язык: Английский

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Age at Menopause and Development of Type 2 Diabetes in Korea

JAMA Network Open, Год журнала: 2025, Номер 8(1), С. e2455388 - e2455388

Опубликована: Янв. 21, 2025

Importance There is limited evidence regarding the association between age at menopause and incident type 2 diabetes (T2D). Objective To investigate whether premature are associated with T2D incidence in postmenopausal Korean women. Design, Setting, Participants This population-based cohort study was conducted among a nationally representative sample from National Health Insurance Service database of 1 125 378 women without who enrolled 2009. The median (IQR) follow-up 8.4 (8.1-8.7) years. Data were analyzed March 2024. Exposures Age (menopause onset <40 years). Main Outcomes Measures primary outcome T2D. Multivariable Cox proportional hazards regression analysis used to estimate hazard ratios (HRs) 95% CIs for by menopause, adjusting potential confounders. Results Of participants (mean [SD] enrollment, 61.2 [8.4] years), 113 864 individuals (10.1%) diagnosed least year after enrollment. Women ages younger than 40 years (premature menopause; HR, 1.13; CI, 1.08-1.18) 44 (HR, 1.03; 1.00-1.06) had increased risk compared those 50 or older, adjustment sociodemographic, lifestyle, cardiometabolic, psychiatric, reproductive factors; developing ( P trend <.001). Body mass index, depressive disorder, prediabetes modified subgroup analyses; example, vs HRs 1.54 (95% 1.14-2.06) BMI less 18.5 1.14 1.00-1.30) 30 greater < .001), 1.28 1.12-1.45) depression 1.11 1.07-1.16) = .01), 1.25 1.18-1.33) not prediabetic 1.04 0.99-1.11) .001). Conclusions Relevance In this study, early higher T2D, highlighting need targeted public health strategies aimed preventing delaying

Язык: Английский

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Serum uric acid to creatinine ratio as a predictor of insulin resistance, β cell function, and metabolic syndrome in normal Korean adults: a cross-sectional study

BMC Endocrine Disorders, Год журнала: 2025, Номер 25(1)

Опубликована: Фев. 5, 2025

This study aimed to determine the relations between serum uric acid creatinine ratio(SUA/Cr) and insulin resistance, pancreatic β cell function, outbreak of metabolic syndrome (MetS) in normal Korean participants. included 14,984 participants without diabetes mellitus or gout who participated 2019–2021 Korea National Health Nutrition Examination Survey. To evaluate resistance homeostasis model assessment (HOMA) was used. Insulin suggested by HOMA-IR, function presented as HOMA-β. Multivariate logistic linear regression analysis used identify factors affecting HOMA-β, MetS. Cut-off values SUA/Cr predict dysfunction, MetS risk were also been suggested. Consequent dividing into tertiles, higher SUA/Cr, HOMA-IR dysfunction cell, rate increased (p < 0.05). associated with existence (adjusted odds ratio [OR]; 1.231 [95% confidence interval [CI]; 1.204–1.259], 1.033 [1.011–1.057], 1.065 [1.026–1.106], respectively). In addition, group clinical significance 3rd tertile. this group, could be predicted when value 8.2716, 8.8710, 7.9762, respectively. Based on total number people, meaningful 7.0175, 6.7925, 6.9369. The may a useful marker for predicting incidence

Язык: Английский

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Persistent influence of past obesity on current adiponectin levels and mortality in patients with type 2 diabetes

The Korean Journal of Internal Medicine, Год журнала: 2025, Номер 40(2), С. 299 - 309

Опубликована: Март 1, 2025

Background/Aims: Adiponectin, a hormone primarily produced by adipocytes, typically shows an inverse relationship with body mass index (BMI). However, some studies have reported positive correlation between the two. Thus, this study aimed to examine adiponectin level and BMI in diabetic patients, focusing on impact of past obesity current levels.Methods: We conducted observational analyzing data from 323 patients at Kyungpook National University Hospital. Based BMIs, participants were categorized into never-obese (nn, n = 106), previously obese (on, 43), persistently (oo, 73) groups based threshold 25 kg/m2. Adiponectin key variables. Kaplan–Meier analysis assessed their all-cause mortality up August 2023, survival differences quartiles follow-up starting patient enrollment (2010–2015).Results: The revealed significant maximum BMI. group exhibited approximately 10% lower levels compared nn group. This association remained after adjusting for BMI, age, sex, highlighting lasting influence previous levels. Furthermore, indicated that lowest quartile had reduced survival, statistically trend (p 0.062).Conclusions: Findings suggest levels, potentially reflecting obesity, are associated decreased underscoring critical role long-term health outcomes.

Язык: Английский

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Obesity classification: a comparative study of machine learning models excluding weight and height data

Revista da Associação Médica Brasileira, Год журнала: 2025, Номер 71(1)

Опубликована: Янв. 1, 2025

Obesity is a global health problem. The aim to analyze the effectiveness of machine learning models in predicting obesity classes and determine which model performs best classification. We used dataset with 2,111 individuals categorized into seven groups based on their body mass index, ranging from average weight class III obesity. Our classification were trained tested using demographic information like age, gender, eating habits without including height variables. study demonstrated that when information, can classify index. random forest provided highest performance scores among all this research. Machine methods have potential be more extensively effective efforts combat

Язык: Английский

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