Dynamic Changes in Gut Microbiota-Derived Metabolite Trimethylamine-N-Oxide and Risk of Type 2 Diabetes Mellitus: Potential for Dietary Changes in Diabetes Prevention
Nutrients,
Год журнала:
2024,
Номер
16(11), С. 1711 - 1711
Опубликована: Май 30, 2024
Background:
A
gut-microbial
metabolite,
trimethylamine
N-oxide
(TMAO),
has
been
associated
with
type
2
diabetes
mellitus
(T2DM).
Few
previous
prospective
studies
have
addressed
associations
between
the
changes
in
TMAO
and
T2DM
incidence.
Methods:
Data
were
derived
from
a
longitudinal
cohort
conducted
2019
to
2021
rural
areas
of
Fuxin
County,
Liaoning
Province,
China,
1515
diabetes-free
participants
aged
above
35
years
included.
The
concentrations
serum
its
precursors
measured
at
two
time
points,
namely
2021.
(ΔTMAO)
separately
tested
logistic
regression
model.
For
further
examination,
odds
ratios
(ORs)
for
calculated
according
combination
levels
ΔTMAO
levels.
Results:
During
median
follow-up
1.85
years,
81
incident
cases
(5.35%)
identified.
Baseline
exhibited
nonlinear
relationship,
first
decreasing
then
increasing,
only
highest
quartile
was
it
risk
T2DM.
OR
3.35
(95%CI:
1.55–7.26,
p
=
0.002),
compared
lowest
quartile.
As
precursors,
choline
level
Q3
Q4
3.37
1.41–8.05,
0.006)
4.72
1.47–15.13,
0.009),
respectively.
When
considering
both
baseline
over
time,
sustained
high
demonstrated
significantly
increased
T2DM,
multivariable-adjusted
8.68
1.97,
38.34).
Conclusion:
Both
initial
long-term
collectively
occurrence
subsequent
events.
Interventions
aimed
normalizing
levels,
such
as
adopting
healthy
dietary
pattern,
may
be
particularly
beneficial
prevention.
Язык: Английский
The Role of the Gut Microbiota in Health, Diet, and Disease with a Focus on Obesity
Foods,
Год журнала:
2025,
Номер
14(3), С. 492 - 492
Опубликована: Фев. 4, 2025
The
gut
microbiota
has
been
increasingly
recognised
as
a
critical
determinant
of
human
health,
influencing
wide
range
physiological
processes.
A
healthy
is
essential
for
maintaining
metabolic,
immune,
and
gastrointestinal
homeostasis,
contributing
to
overall
well-being.
Alterations
in
its
composition
functionality,
often
referred
microbial
dysbiosis,
are
strongly
associated
with
the
development
gut-related
systemic
diseases.
synthesises
several
components
interacts
epithelial
cell
receptors,
processes
that
extend
beyond
nutritional
status
pathogenesis
diseases
such
obesity,
which
their
known
contribution
status.
Therefore,
this
state-of-the-art
review
findings
from
recent
studies
on
composition,
functions,
factors
microbiota,
focus
role
obesity.
systematic
search
peer-reviewed
literature
was
conducted
ensure
comprehensive
coverage,
while
expert
insights
incorporated
discuss
emerging
research
directions
future
perspectives
field.
Язык: Английский
Relationship between the Mediterranean Diet and Metabolic Syndrome and Each of the Components That Form It in Caucasian Subjects: A Cross-Sectional Trial
Nutrients,
Год журнала:
2024,
Номер
16(12), С. 1948 - 1948
Опубликована: Июнь 19, 2024
The
main
objective
of
this
work
is
to
investigate
the
relationship
between
Mediterranean
diet
(MD)
and
metabolic
syndrome
(MetS)
its
components
in
Caucasian
subjects
35
74
years.
secondary
analyze
sex
differences.
Methods:
A
cross-sectional
trial.
This
study
utilized
data
from
EVA,
MARK,
EVIDENT
studies,
a
total
3417
with
mean
age
±
SD
60.14
9.14
years
(57%
men)
were
included.
We
followed
five
criteria
established
National
Cholesterol
Education
Program
III
define
MetS.
MD
was
assessed
14-item
adherence
screener
(MEDAS)
used
PREDIMED
study.
Good
considered
when
value
higher
than
median
value.
Results:
MEDAS
questionnaire
5.83
2.04
(men
5.66
2.06
women
6.04
1.99;
p
<
0.001).
Adherence
observed
by
38.6%
(34.3%
men
40.3%
women;
MetS
41.6%
(39.0%
45.2%
In
multiple
regression
analysis,
after
adjusting
for
possible
confounders,
showed
negative
association
number
per
subject
(β
=
−0.336),
different
MetS:
systolic
blood
pressure
−0.011),
diastolic
−0.029),
glycemia
−0.009),
triglycerides
−0.004),
waist
circumference
−0.026),
except
HDL-cholesterol
which
positive
0.021);
0.001
all
cases.
logistic
analysis
performed,
we
found
that
an
increase
associated
decrease
probability
(OR
0.56)
components:
levels
≥
130/85
mmHg
0.63),
fasting
plasma
glucose
100
mg/dL
0.62),
triglyceride
150
0.65),
88
cm
≥102
0.74),
increased
high-density
lipoprotein
cholesterol
40
<50
1.70);
results
similar,
both
regression.
Conclusions:
our
indicate
greater
MD,
lower
presenting
result
repeated
sex.
More
studies
are
needed
clarify
these
can
be
extended
rest
countries,
other
countries
outside
basin.
Язык: Английский
Effects of dynamic high-pressure microfluidization treatment on the structural, physicochemical, and digestive properties of wheat starch-Lonicera caerulea berry polyphenol complex
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
281, С. 136150 - 136150
Опубликована: Окт. 5, 2024
Язык: Английский
Association between Baltic sea diet and healthy Nordic diet index with risk of type 2 diabetes mellitus: a case–control study
Frontiers in Endocrinology,
Год журнала:
2025,
Номер
16
Опубликована: Март 27, 2025
Backgrounds
Recent
evidence
shows
the
beneficial
effects
of
Baltic
Sea
diet
score
(BSDS)
and
healthy
Nordic
index
(HNDI)
on
chronic
diseases;
however,
there
is
no
to
investigate
them
risk
type
2
diabetes
mellitus
(T2DM).
The
purpose
this
study
was
associations
between
BSDS
HNDI
with
T2DM.
Methods
This
used
a
case-control
design
participants
aged
18
60
diagnosed
in
last
six
months
(225
cases,
450
controls).
evaluation
employed
validated
168−item
semi−quantitative
food
frequency
questionnaire
(FFQ).
Binary
logistic
regression
determine
how
OBS
T2DM
are
related.
Results
mean
scores
for
were
16.00
±
2.49
11.99
2.61,
respectively.
final
model,
which
accounted
confounding
variables,
indicated
that
increased
adherence
associated
reduced
likelihood
developing
(OR
=
0.42;
95%
CI
0.18–0.98;
p
trend
0.043).
Additionally,
significant
association
observed
lower
higher
both
unadjusted
0.49,
0.31–0.77;
0.001)
adjusted
0.48,
0.32–0.89;
0.003)
models.
Conclusion
Our
research
following
significantly
reduces
Commitment
dietary
pattern
may
also
reduce
related
factors.
Further
longitudinal
studies
across
diverse
populations
needed
validate
these
findings.
Язык: Английский
Gut Microbiota and Metabolic Dysregulation in Elderly Diabetic Patients: Is There a Gender-Specific Effect
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(9), С. 3103 - 3103
Опубликована: Апрель 30, 2025
Background/Objectives:
The
aim
of
this
study
was
to
qualitatively
and
quantitatively
assess
the
bacterial
domain
gut
microbiome
in
elderly
patients
with
type
2
diabetes
(T2D),
a
focus
on
sex
differences,
glycemic
control,
lipid
disorders.
Methods:
This
included
60
older
adults
T2D
(38
women
22
men)
treated
metformin
or
combination
insulin.
microbiota
profiled
using
16S
rRNA
gene
sequencing.
Statistical
analyses,
including
correlation
analysis
multiple
regression,
were
performed
identify
associations
between
microbial
taxa,
sex,
metabolic
parameters.
Results:
No
statistically
significant
differences
alpha
beta
diversity
observed
sexes.
Multiple
regression
indicated
positive
relationship
Tenericutes
HbA1c
male
participants
(β
=
2.22931,
CI
[0.75,
3.70],
R
0.67;
R2
0.36;
unadjusted
p
0.0052;
adjusted
0.0496).
In
female
participants,
G0'
-2.24107,
[-3.19,
-1.30],
0.78;
0.58;
0.00003;
0.0005)
-1.86670,
[-2.61,
-1.12],
0.00001;
0.0003)
correlated
negatively
Verrucomicrobia
as
well
-1.90427,
[-2.95,
-0.85],
0.46;
0.17;
0.0008;
0.007)
-1.69561,
[-2.52,
-0.87],
0.0002;
0.002)
OD1
bacteria,
known
Parcubacteria.
Conclusions:
population
diabetes,
biological
did
not
significantly
affect
diversity.
However,
several
exploratory
taxa
parameters
differed
men
women,
suggesting
that
may
influence
specific
aspects
microbiota-metabolism
interactions.
These
preliminary
findings
underscore
importance
considering
both
age-
sex-related
factors
when
investigating
context
diabetes.
Язык: Английский
Gut microbiota and kidney diseases. Literature review
Nephrology and Dialysis,
Год журнала:
2024,
Номер
26(3), С. 283 - 302
Опубликована: Сен. 20, 2024
Recent
technological
advances
have
significantly
enhanced
our
understanding
of
the
role
microbial
communities
play
in
human
body.
The
gut
microbiota,
one
most
diverse
microbiomes,
consists
over
35,000
bacterial
species
and
10
million
genes,
leading
researchers
to
consider
it
as
an
additional
organ.
This
whiles
relatively
stable
within
each
individual
highly
influenced
by
exogenous
endogenous
factors.
Collectively,
microbiota
functions
a
"second
genome",
profoundly
impacting
host’s
metabolic
pathways
regulating
body’s
complex
homeostatic
balance.
Research
into
"microbe–host"
interaction,
both
health
disease,
has
garnered
worldwide
scientific.
In
chronic
kidney
disease
(CKD),
undergoes
significant
changes,
growing
evidences
suggests
that
dysbiosis
plays
crucial
progression
renal
failure.
Key
pathological
process,
such
production
gut-derived
uremic
toxins,
decreased
synthesis
short–
chain
fatty
acids,
altered
intestinal
pH,
compromised
barrier
function,
heightened
systemic
inflammation,
are
all
linked
microbiota.
However,
relationship
between
these
changes
pathogenesis
requires
further
investigation.
Advances
microbiome
research,
including
metagenomic
metatranscriptomic
analyses,
alongside
proteomic,
metabolomics,
immunomic
studies,
greatly
expanded
microbiomal
community
structure
functions.
These
technologies,
coupled
with
mechanistic
experiments
model
systems,
deepened
knowledge
how
influences
metabolism.
Current
research
aims
explore
bidirectional
host,
identifying
potential
interventions
could
help
restore
mutualistic
relationship.
Язык: Английский
Gut microbiota modulating therapy for diabetes mellitus should be individualized
World Journal of Diabetes,
Год журнала:
2024,
Номер
15(10), С. 2152 - 2156
Опубликована: Сен. 26, 2024
In
this
editorial,
we
commented
on
two
articles
published
online
in
August
and
September
2024
the
World
Journal
of
Diabetes
,
which
focused
modifying
gut
microbiota
(GM)
to
prevent
or
delay
progression
diabetes
mellitus
(DM)
DM-related
complications.
Numerous
studies,
many
are
animal
have
indicated
potential
role
GM
pathogenesis
DM.
However,
detailed
causality
mechanisms
between
DM
not
been
fully
clarified.
Although
there
some
reports
a
treating
DM,
most
lack
long-term
observations
mechanistic.
Additionally,
its
might
vary
among
individuals;
therefore,
GM-targeted
interventions
should
be
individualized
realize
their
therapeutic
potential.
Язык: Английский