Indian Journal of Clinical Biochemistry, Год журнала: 2017, Номер unknown
Опубликована: Ноя. 14, 2017
Язык: Английский
Experimental Gerontology, Год журнала: 2024, Номер 195, С. 112531 - 112531
Опубликована: Июль 31, 2024
Polyunsaturated fatty acids (PUFA) are known to have a regulatory effect on oxidative and inflammatory processes. This study aimed identify the relationship between blood PUFA status circulatory markers of stress inflammation in cohort 172 subjects. The population was divided by sex into three age groups: adults (18-64 years old, n = 69), older (65-89 54), long-lived individuals (LLIs, 90-111 49). Whole content quantified using gas chromatography. Additionally, serum levels C-reactive protein (CRP), paraoxonase (PON), Trolox equivalent antioxidant capacity (TEAC), malondialdehyde (MDA) were measured. Our results showed that higher omega-3 (n-3) index adult females predictor lower MDA concentrations (p 0.038). Conversely, total n-3 n-6 positively related values among LLI men < 0.05), while inversely correlated with 0.05). Interestingly, increased TEAC 0.007), arachidonic acid (AA)/eicosapentaenoic (EPA) ratio 0.006). These findings suggest cellular is changes AA/EPA females, whereas may enhance men. Overall, our highlights complex, sex-specific interactions profiles across different groups.
Язык: Английский
Процитировано
9
Aging and Disease, Год журнала: 2021, Номер 12(7), С. 1773 - 1773
Опубликована: Янв. 1, 2021
People are living longer, but lifespan increase does not coincide with a boost in health-span.Thus, improving the quality of life older people is priority.Centenarians reach extreme longevity relatively good health status, escaping or delaying fatal strongly invalidating diseases.Therefore, studying processes involved important to explain biological mechanisms and well-being, since knowledge born from this approach can provide valuable information on how slow aging.We performed present study well characterized very homogeneous sample 173 Western Sicily, update existing literature some phenotypic aspects aging propose range values for people.We classified 5 age groups, young adults centenarians, understand gender-related variations different parameters under study.We collected anamnestic data anthropometric, bioimpedance, molecular, haematological, oxidative, hematochemical tests, adopting multidimensional analysis approach.An evidence that there differences related both gender several biomarkers.Indeed, seem be still poorly considered inadequately investigated as other medical studies.Moreover, we often observed comparable between centenarians rather than non-agenarians hypothesizing sort slowdown, almost followed by reversal trend, decay systemic deterioration.The provides indications aging, benefits those who more vulnerable disease disability.The identification factors predispose long healthy enormous interest translational medicine an world.
Язык: Английский
Процитировано
34
International Journal of Molecular Sciences, Год журнала: 2014, Номер 15(11), С. 20997 - 21010
Опубликована: Ноя. 14, 2014
Paraoxonases (PON) are three enzymes (PON1, PON2 and PON3) that play a role in the organism’s antioxidant system; alterations which associated with diseases involving oxidative stress. In this review, we summarize evidence of PON related to pathogenesis coronary artery disease (CAD) atherosclerosis. We searched electronic databases (PubMed, Scopus Cochrane Database) no date limit. All articles selected investigated enzymatic activity and/or gene polymorphisms. The selection focused on relation atherosclerosis, CAD myocardial infarction. exclusion criteria were sample size <100 patients, non-human studies, editorials systematic reviews without restrictions country origin. With these criteria, identified thirty-five prospective studies published between 1986 2014 total 28,164 participants. relationship polymorphisms was not conclusive, but most support concept PON1 levels do influence atheroma formation. Conversely, relationships PON3 vs. have been extensively investigated. Our review current data concludes bases paraoxonases involvement atherosclerosis poorly understood issue requires future comprehensive, multi-centered studies.
Язык: Английский
Процитировано
44
Disease Markers, Год журнала: 2022, Номер 2022, С. 1 - 9
Опубликована: Март 10, 2022
To review and compare the PON-1 arylesterase activity between coronary artery disease (CAD) non-CAD patients.
Язык: Английский
Процитировано
21
Sao Paulo Medical Journal, Год журнала: 2016, Номер 134(3), С. 234 - 239
Опубликована: Май 11, 2016
Red grape seed extract (RGSE) contains oligomeric proanthocyanidin complexes as a class of flavonoids. These compounds are potent antioxidants and exert many health-promoting effects. This study aimed to determine the effects RGSE on serum levels triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL-C), low-density (LDL-C), apolipoprotein AI (apo-AI) paraoxonase (PON) activity in patients with mild moderate hyperlipidemia (MMH).A randomized double-blind placebo-controlled clinical trial was conducted at Shahid-Modarres Hospital (Tehran, Iran) Tabriz University Medical Sciences. Seventy MMH were randomly assigned receive treatment (200 mg/day RGSE) or placebo for eight weeks.Significant elevation apo-AI (P = 0.001), HDL-C 0.001) PON marked decreases concentrations TC 0.015), TG 0.011) LDL-C 0.014) found cases. significantly correlated (r 0.270; P < 0.01) 0.45; 0.001). Significant differences between control groups (before after treatment) 0.03), 0.002) seen.It is possible that increases mostly through increasing patients. It may thus have potential beneficial preventing oxidative stress atherosclerosis these
Язык: Английский
Процитировано
38
The Journal of Nutritional Biochemistry, Год журнала: 2017, Номер 48, С. 1 - 8
Опубликована: Июнь 6, 2017
Язык: Английский
Процитировано
37
Clinical Science, Год журнала: 2016, Номер 130(7), С. 491 - 497
Опубликована: Фев. 17, 2016
The maternal adaptation to pregnancy includes hyperlipidaemia, oxidative stress and chronic inflammation. In non-pregnant individuals, these processes are usually associated with poor vascular function. However, function is enhanced in pregnancy. It not understood how this achieved the face of adverse metabolic inflammatory environment. Research into cardiovascular disease demonstrates that plasma HDL (high-density lipoprotein), by merit its functionality rather than concentration, exerts protective effects on endothelium. has vasodilatory, antioxidant, anti-thrombotic anti-inflammatory effects, can protect against endothelial cell damage. pregnancy, concentration starts rise at 10 weeks gestation, peaking 20 weeks. initial occurs around time establishment feto-placental circulation, a when trophoblast plugs spiral arteries released, generating stress. Thus there intriguing possibility new improved synthesized circulation. obese and, greater extent, pre-eclampsia, levels significantly decreased reduced. Wire myography studies have shown an association between content apolipoprotein AI, major protein constituent HDL, blood vessel relaxation. These observations lead us hypothesize function, increases order endothelium pre-eclampsia fails occur.
Язык: Английский
Процитировано
31
Oncotarget, Год журнала: 2016, Номер 8(12), С. 19443 - 19454
Опубликована: Дек. 27, 2016
Paraoxonase1 (PON1) activity is closely related to coronary artery disease (CAD). However, whether PON1 can predict the degree of stenosis remains unknown. In present study, serum and factors that influence were analyzed in 186 patients with diagnostic angiography. The was determined using a spectrophotometry-based assay angiography, which severity graded clinically defined as single- or multi-vessel >50%. Target lesion quantified via quantitative angiography (QCA). significantly decreased CAD group, multiple subgroup, diabetes mellitus subgroup compared each control group. positively correlated High density lipoprotein cholesterol (HDL-C) Apolipoprotein A1 (ApoA1). Males, smoking, diabetes, heart failure identified influenced activity. Furthermore, Receiver Operating Characteristic Curve (ROC) analysis indicated cut-off point 330 U/L could sensitivity 52% specificity 65%. conclusion, low predicted lesion, particularly vessel lesions, smokers, may represent biochemical marker for CAD.
Язык: Английский
Процитировано
30
The Scientific World JOURNAL, Год журнала: 2014, Номер 2014, С. 1 - 6
Опубликована: Янв. 1, 2014
The aim of the study was to compare effect maximal exercise (ME) on paraoxonase (PON) and arylesterase (ARE) activity depending lifestyle in respect physical activity. performed 46 young men divided into two groups: sedentary (S) physically active (PA). All participants ME a treadmill. PON1 activities, FRAP, uric acid, bilirubin, TBARS, lipid profile were determined their blood before, at bout of, after ME. No significant differences activities found between S PA subjects baseline. Nearly all biochemicals increased both groups. Both PON ARE only subjects. ARE/HDL-C ratio difference response groups may be result adaptation regular We suggest that marker antioxidant protection an indicator exercise.
Язык: Английский
Процитировано
24
Scientific Reports, Год журнала: 2020, Номер 10(1)
Опубликована: Апрель 14, 2020
Abstract Since aortic aneurysms (AAs) are mostly asymptomatic, but they have a high mortality rate upon rupture, their detection and progression evaluation clinically important issues. To discover diagnostic biomarkers for AA, we performed proteome analysis of media from patients with thoracic atherosclerotic AA (TAAA), comparing protein levels between the aneurysm normal tissue areas. After hierarchical clustering data, samples were classified into three groups, regardless morphological features. This classification was shown to reflect disease stage identified by pathological examination. proteomics-based staging system enabled us identify more significantly altered proteins than system. In subsequent data analysis, Niemann-Pick type C2 (NPC2) insulin-like growth factor-binding 7 (IGFBP7) selected as novel biomarker candidates compared previously reported biomarker, thrombospondin 1 (THBS1). Blood concentrations NPC2 IGFBP7 increased, while THBS1 decreased in TAAA abdominal patients. Receiver operating characteristic healthy controls showed that higher specificity sensitivity THBS1. Thus, promising AA.
Язык: Английский
Процитировано
17