Journal of Future Foods,
Год журнала:
2022,
Номер
2(1), С. 41 - 52
Опубликована: Март 1, 2022
The
coconut
tree
(Cocos
nucifera)
which
is
also
known
as
the
"Tree
of
life"
has
its
own
values
in
each
part
and
oil
more
prestigious
among
them.
At
present,
consumption
booming
all
around
world
owing
to
tremendous
health
benefits.
unique
chemical
composition
enriched
with
medium
chain
fatty
acids
(MCFAs)
led
exploration
these
nutritional
therapeutic
influences.
Unlike
long
(LCFAs),
MCFAs
generated
from
digestion
triglycerides
(MCTs)
a
specific
pathway
for
metabolism,
it
bypasses
lymphatic
system
enter
liver
directly
through
portal
vein.
Due
such
distinct
attributes
absorption
MCTs
are
readily
capable
forming
ketone
bodies
than
other
triglycerides.
These
competent
energy
source
brains,
especially
those
having
cognitive
impairments
like
Alzheimer's
disease
(AD).
AD
neurodegenerative
characterized
clinically
by
accelerating
shortfalls
memory
behavioral
changes.
principal
biochemical
hallmarks
behind
pathogenesis
development
extracellular
amyloid
β
plaques
accumulation
intracellular
neurofibrillary
tangles.
Occurrence
Cardiovascular
diseases
(CVD)
elevated
LDL
levels,
hypertension,
Type
2
diabetes,
obesity,
insulin
resistance
some
key
risk
factors
that
responsible
increasing
prevalence
incidence
AD.
There
sufficient
evidence
prove
metabolized
absorbed
way
retards
severity
physiological
factors.
Besides,
endowed
many
polyphenolic
compounds
serving
antioxidants
combating
oxidative
stress
inflammation,
turn
downregulates
etiology
But
depending
on
different
processing
conditions
applied
extraction
techniques
oil,
variations
antioxidant
capacity
can
take
place.
Even
though
there
inadequacies
peer-reviewed
large
cohort
clinical
data
run,
this
article
reviews
constituents,
metabolism
have
positive
findings
potentiality
treat
supplement.
Frontiers in Aging Neuroscience,
Год журнала:
2019,
Номер
11
Опубликована: Ноя. 20, 2019
Neurons
are
highly
specialized
postmitotic
cells
that
inherently
dependent
on
mitochondria
owing
to
their
high
bioenergetic
demand.
Mitochondrial
dysfunction
is
therefore
associated
with
various
age-related
neurodegenerative
disorders
such
as
Alzheimer's
disease
(AD),
wherein
accumulation
of
damaged
and
dysfunctional
has
been
reported
early
symptoms
further
contributing
progression.
In
AD,
impairment
mitochondrial
function
causes
deficiency,
intracellular
calcium
imbalance
oxidative
stress
thereby
aggravating
the
effect
Aβ
tau
pathologies,
leading
synaptic
dysfunction,
cognitive
memory
loss.
Although
there
reports
suggesting
intricate
parallelism
between
AD
pathologies
A
aggregation
hyperphosphorylated
accumulation,
factors
drive
pathogenesis
either
unclear.
addition,
emerging
evidence
suggests
quality
control
(QC)
mechanisms
mitophagy
impaired
in
AD.
As
an
important
QC
mechanism,
plays
a
critical
role
maintaining
neuronal
health
function.
Studies
show
different
proteins
involved
mitophagy,
dynamics
biogenesis
affected
The
compromised
may
also
be
attributed
autophagosome-lysosome
fusion
defects
lysosomal
acidification.
Therapeutic
interventions
aiming
restore
functions
can
used
strategy
for
ameliorating
pathogenesis.
Recent
implicates
microglial
activation
via
induction
reducing
amyloid
plaque
load.
This
review
summarizes
current
developments
field
Journal of Personalized Medicine,
Год журнала:
2023,
Номер
13(4), С. 652 - 652
Опубликована: Апрель 10, 2023
Brain-derived
neurotrophic
factor
(BDNF)
has
a
crucial
function
in
the
central
nervous
system
and
sensory
structures
including
olfactory
auditory
systems.
Many
studies
have
highlighted
protective
effects
of
BDNF
brain,
showing
how
it
can
promote
neuronal
growth
survival
modulate
synaptic
plasticity.
On
other
hand,
conflicting
data
about
expression
functions
cochlear
been
reported.
Several
clinical
experimental
research
showed
alterations
levels
neurodegenerative
diseases
affecting
peripheral
system,
suggesting
that
be
promising
biomarker
most
conditions,
Alzheimer’s
disease,
shearing
loss,
or
impairment.
Here,
we
summarize
current
concerning
brain
domains
(olfaction
hearing),
focusing
on
BDNF/TrkB
signalling
pathway
activation
both
physiological
pathological
conditions.
Finally,
review
significant
highlighting
possibility
to
target
as
early
diagnosis
cognitive
neurodegeneration,
opening
new
opportunities
develop
effective
therapeutic
strategies
aimed
counteract
neurodegeneration.
International Journal of Molecular Sciences,
Год журнала:
2021,
Номер
22(14), С. 7710 - 7710
Опубликована: Июль 19, 2021
The
blood-brain
barrier
(BBB)
regulates
the
delivery
of
oxygen
and
important
nutrients
to
brain
through
active
passive
transport
prevents
neurotoxins
from
entering
brain.
It
also
has
a
clearance
function
removes
carbon
dioxide
toxic
metabolites
central
nervous
system
(CNS).
Several
drugs
are
unable
cross
BBB
enter
CNS,
adding
complexity
drug
screens
targeting
disorders.
A
well-functioning
is
essential
for
maintaining
healthy
tissue,
malfunction
BBB,
linked
its
permeability,
results
in
toxins
immune
cells
CNS.
This
impairment
associated
with
variety
neurological
diseases,
including
Alzheimer's
disease
Parkinson's
disease.
Here,
we
summarize
current
knowledge
about
neurodegenerative
diseases.
Furthermore,
focus
on
recent
progress
using
human-induced
pluripotent
stem
cell
(iPSC)-derived
models
study
BBB.
We
review
potential
novel
cell-based
platforms
modeling
address
advances
key
challenges
technology
human
Finally,
highlight
future
directions
this
area.
Biomolecules,
Год журнала:
2022,
Номер
12(11), С. 1676 - 1676
Опубликована: Ноя. 11, 2022
Damage
or
loss
of
brain
cells
and
impaired
neurochemistry,
neurogenesis,
synaptic
nonsynaptic
plasticity
the
lead
to
dementia
in
neurodegenerative
diseases,
such
as
Alzheimer's
disease
(AD).
Injury
synapses
neurons
accumulation
extracellular
amyloid
plaques
intracellular
neurofibrillary
tangles
are
considered
main
morphological
neuropathological
features
AD.
Age,
genetic
epigenetic
factors,
environmental
stressors,
lifestyle
contribute
risk
AD
onset
progression.
These
factors
associated
with
structural
functional
changes
brain,
leading
cognitive
decline.
Biomarkers
reflect
cause
specific
function,
especially
pathways
neurotransmission,
neuroinflammation,
bioenergetics,
apoptosis,
oxidative
nitrosative
stress.
Even
initial
stages,
is
Aβ
neurotoxicity,
mitochondrial
dysfunction,
tau
neurotoxicity.
The
integrative
amyloid-tau-mitochondrial
hypothesis
assumes
that
primary
neurotoxicity
oligomers
oligomers,
their
mutual
synergy.
For
development
new
efficient
drugs,
targeting
elimination
potentiation
effects,
unwanted
protein
interactions
biomarkers
(mainly
dysfunction)
early
stage
seems
promising.
Pharmaceuticals,
Год журнала:
2022,
Номер
15(12), С. 1560 - 1560
Опубликована: Дек. 14, 2022
Alzheimer’s
disease
(AD)
is
a
neurodegenerative
disorder
characterized
by
decreased
synaptic
transmission
and
cerebral
atrophy
with
appearance
of
amyloid
plaques
neurofibrillary
tangles.
Cognitive,
functional,
behavioral
alterations
are
commonly
associated
the
disease.
Different
pathophysiological
pathways
AD
have
been
proposed,
some
which
interact
influence
one
another.
Current
treatment
for
mainly
involves
use
therapeutic
agents
to
alleviate
symptoms
in
patients.
The
conventional
single-target
approaches
do
not
often
cause
desired
effect
due
its
multifactorial
origin.
Thus,
multi-target
strategies
since
undertaken,
aim
simultaneously
target
multiple
targets
involved
development
AD.
In
this
review,
we
provide
an
overview
pathogenesis
current
drug
therapies
Additionally,
rationales
examples
drugs
pharmacological
actions
against
also
discussed.
