Высокая эффективность современной химиолучевой терапии позволила добиться больших успехов в лечении онкогематологических заболеваний. Основой многих схем полихимиотерапии первой линии лечения остаются антраци клиновые антибиотики. Эффективное лечение основного заболевания в ряде случаев сопровождается развитием различных осложнений со стороны сердечно-сосудистой системы, в том числе очень тяжелых, с развитием летального исхода. Необходимо учитывать возможность развития не только острой кардиотоксичности, но и различных осложнений со стороны сердечнососудистой системы после завершения противоопухолевого лечения. Алгоритм подготовки пациентов к химиолучевой терапии, должен обязательно включатъ обследование сердечно-сосудистой системы до начала лечения, в дальнейшем необходимо регулярное обследование на протяжении терапии. Профилактика и лечение кардиотоксичности являются сложными клиническими задачами в …
CARDIOVASCULAR THERAPY AND PREVENTION,
Год журнала:
2022,
Номер
21(5), С. 3182 - 3182
Опубликована: Июнь 4, 2022
Aim.
To
assess
the
right
ventricle
(RV)
during
chemotherapy
(CT)
in
patients
with
breast
cancer
(BC).
Material
and
methods
.
The
study
included
40
women
aged
35-72
years
BC
who
underwent
anthracycline
chemotherapy.
main
group
(n=40)
BC,
examined
at
first
contact,
37
of
whom
were
reexamined
after
6
months.
Control
(n=25)
without
BC.
Results
In
group,
median
transverse
dimension
anterior
wall
thickness
RV
significantly
greater
than
control
(p<0,001).
Early
diastolic
transtricuspid
flow
velocity
(Et)
months
was
lower
(p=0,003).
ratio
Et
to
late
(At)
(Et/At)
decreased
follow-up
period
(p<0,05)
when
compared
baseline
values.
Higher
values
Tei
index
noted
one
(p<0,05).
Using
logistic
regression
for
index,
model
radiation
therapy,
total
dose,
negative
affectivity
score
as
follows:
F(3,17)=12,548,
p<0,001,
R
2
=0,729.
For
Et/At
ratio,
additional
therapy
heart
rate
significant
factors
F(2,16)=12,548,
p=0,005,
=0,526.
Conclusion
Against
background
CT,
deterioration
systolic
(increase
volume)
(decrease
ratio)
function
noted.
Acta Biomedica Scientifica (East Siberian Biomedical Journal),
Год журнала:
2021,
Номер
6(4), С. 87 - 99
Опубликована: Окт. 17, 2021
Cardiovascular
disease
has
serious
economic
and
social
consequences
that
affect
people,
health
systems
societies
around
the
world.
Ischemic
heart
is
one
of
main
global
causes
death
population,
its
growth
predicted
in
coming
years.
This
fact
continues
to
be
concern
health,
services.
remains
most
common
cause
death,
age-standardized
rates
are
higher
for
men
than
women.
comorbidity
increases
significantly
with
age.The
combination
ischemic
comorbid
pathology
noted
cancer
incidence,
bronchial
asthma,
non-alcoholic
fatty
liver
disease,
type
2
diabetes
mellitus,
chronic
obstructive
pulmonary
periodontal
etc.
It
necessary
analyze
existing
past
diseases,
risk
factors
predictors
available
patient.
The
presence
concomitant
diseases
quite
often
requires
additional
diagnostic
methods
changes
tactics
treating
coronary
due
some
them
a
contraindication
use
certain
groups
drugs.
Periodontal
includes
wide
range
inflammatory
conditions
supporting
structures
teeth,
which
can
lead
tooth
loss
contribute
systemic
inflammation.
associated
several
artery
disease.
imperative
clinicians
understand
link
between
cardiovascular
Comprehensive
treatment
periodontitis
restoration
healthy
periodontium
help
reduce
overall
inflammation
body
risks
Safety and Risk of Pharmacotherapy,
Год журнала:
2021,
Номер
9(4), С. 165 - 172
Опубликована: Ноя. 8, 2021
Antitumour
herbal
medicines
based
on
pink
periwinkle
and
yew
tree
alkaloids
are
included
in
combination
therapies
for
many
types
of
cancer.
The
use
these
classes
products
may
entail
cardiotoxic
effects
leading
to
life-threatening
conditions.
aim
the
study
was
analyse
scientific
literature
anticancer
drugs
(taxanes)
(vinca
alkaloids).
results
analysis
demonstrated
that
main
manifestations
taxane-induced
cardiotoxicity
were
bradycardia,
atrioventricular
block,
atrial
ventricular
arrhythmias.
Concomitant
taxanes
anthracycline
antibiotics
exacerbated
both
drug
classes.
vinca
associated
with
haematological
toxicity
form
neutropenia,
while
effect
rarely
observed
during
monotherapy.
Raising
awareness
among
oncologists,
cardiologists,
other
specialists
involved
management
cancer
patients
about
potential
cardiac
complications
antitumour
therapy
contributes
early
detection
adverse
reactions
allows
individual
correction
treatment
regimens,
especially
predisposition
cardiovascular
disease.
