EFFICIENCY AND SAFETY OF THE DOMESTIC DEVICE KERATOLINK FOR THE TREATMENT OF PATIENTS WITH BACTERIAL CORNEAL ULCERS

Опубликована: Янв. 25, 2025

Ultraviolet cross-linking (UVCL) of corneal collagen is one the promising methods for treating bacterial ulcers. Purpose work: to evaluate effectiveness and safety use a new domestic device UVCL KERATOLINK in treatment patients with ulcer. Material methods. Local was performed 24 (24 eyes) aged from 18 74 years, who made up main group. The comparison group included 10 same age To treat ulcerative lesions, drug therapy (antibacterial, corticosteroid, tear replacement reparative) used both groups, but also procedure 5 minutes using “accelerated cross-linking” program. Each patient underwent 3 procedures an interval 2 days. Ophthalmological examination before treatment, days after 1st, 2nd 3rd procedures, as well 1, 3, 6 months completion visometry, tonometry, microbiological discharge, determination size defect, optical coherence tomography anterior department eye (OCT-AS). examined at time set Results. All were completed without complications, no adverse events identified, all cases recovery period uneventful. UVCL, average uncorrected visual acuity increased 0.029±0.026 0.195±0.175. Already third procedure, there absence microorganisms cultures, significant decrease area depth defect (associated its almost complete epithelization) inflammatory edema according OCT-АS data. epithelization 12 Subsequently, stable healing observed months, relapses detected. In group, on 15th day observation, epithelialization achieved only 40% patients. Conclusion. technically simple, minimally invasive method A reduction increase indicate accelerated procedure. local protocol exposure helps comfort tolerability reduce risk complications.

Язык: Английский

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The effects of corneal collagen cross-linking on the corneal structure in keratoconus

Russian Annals of Ophthalmology, Год журнала: 2020, Номер 136(5), С. 268 - 268

Опубликована: Янв. 1, 2020

The article reviews the key information regarding morphological changes in keratoconic corneas and dramatic alterations of corneal tissue induced by cross-linking according to data obtained with vivo confocal microscopy, presents basic on keratoconus visualization techniques widely used for diagnosis, monitoring ectasia, as well efficacy assessment its treatment, lists principles procedure microscopy consideration morphology specifics corneas. also discusses prospective benefits further research longitudinal studies aimed define origin develop advanced protocols.В обзоре представлены основные сведения о морфологических изменениях, наблюдаемых в роговице при кератоконусе, и результаты наиболее значимых исследований влияния кросслинкинга роговичного коллагена на структуру роговицы — по данным конфокальной микроскопии vivo. В статье приведено описание визуализирующих методов исследования роговицы, применяемых для диагностики мониторинга кератоконуса, а также оценки эффективности лечения. Отображены принципы ракурсе особенностей морфологии кератоконусе. обсуждены возможные перспективы дальнейших целях изучения природы кератоконуса разработки эффективных модификаций коллагена.

Язык: Русский

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Treating protracted corneal ulcers with UVA corneal collagen crosslinking: clinical cases

Russian Ophthalmological Journal, Год журнала: 2021, Номер 14(3), С. 106 - 112

Опубликована: Сен. 15, 2021

It has recently been proposed to use ultraviolet (UVA) corneal collagen crosslinking as an alternative method of treating bacterial ulcerative lesions the cornea. Ambivalent results regarding efficacy and safety this treatment limit its implementation in clinical practice so far. The purpose work is analyze three cases involving a new device for local UVA complex protracted-course ulcers with suspected development mixed fungal infection. Material methods. For dynamic follow-up patients, we used biomicroscopy fluorescein test, photo registration optical coherence tomography anterior part eye. Inflammatory changes were assessed using point scale. Results. 3–5 procedures exposure (with instillations 0.1% riboflavin solution) lasting minutes each given interval 2–4 days ensured stable fast epithelialization cornea significant increase visual acuity inflammatory process outcome. Conclusion. first portable have shown high therapeutic efficiency good prospects further practice.

Язык: Английский

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Treatment of corneal ulcers by local ultraviolet crosslinking (an experimental study)

Russian Ophthalmological Journal, Год журнала: 2020, Номер 13(4), С. 48 - 57

Опубликована: Дек. 17, 2020

Purpose : to compare the effectiveness of corneal ulcer treatment by antibiotic therapy and local ultraviolet crosslinking in a clinical morphological experimental study using new Crosscor device. Material methods . The was performed on 15 rabbits (30 eyes) with model ulceration caused Staphylococcus aureus. Rabbits were divided into 3 groups 5 specimens each (10 eyes). Group 1 received A range (UVA) (CL) cornea device (3 procedures lasting 5, 6 minutes given intervals three days). In group 2, CL combined antibacterial (AB): instillations tobramycin 0.3 % ofloxacin ointment mg / g 4 times day for 14 days. control group, only AB given. dynamics inflammation, intensity turbidity size evaluated biomicroscopy, fluorescein test, photoregistration anterior part eye, according point system. Morphological changes determined light microscopy (Leica DFC 420C digital camera). Results complete healing defect noted 9th observation; 2 (CL + AB), diameter reduced 1.6 ± 0.5 mm, (AB) it 1.9 mm (p < 0.05). total score inflammatory 9 1st 0.8 1.3, 2nd 3.6 0.8, 3.7 0.4 On 9, all cases slight clouding formed (0–-1 point); 90 rough vascularization points). examination eyes showed that avascular scars an ordered arrangement fibrous tissue fibrils formed. Conclusion data obtained indicate significantly higher efficiency UVA as compared therapy.

Язык: Английский

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Results of Accelerated Local Cross-Linking in Keratoconus

Ophthalmology in Russia, Год журнала: 2023, Номер 20(3), С. 437 - 443

Опубликована: Сен. 30, 2023

Objective of the study. To analyze effectiveness accelerated local corneal cross linking in treatment keratoconus (KC). Patients and methods. Thirty-four patients (42 eyes) were included study: 19 people (24 with stage II keratoconus, 15 (18 III Amsler keratoconus. All examined using following methods: visometry, refractokeratometry, keratotopography, optical coherence tomography anterior segment, endothelial cell density calculation before after surgical 6 months, 1, 2 3 years. Results . Significant increase uncorrected (UDVA) corrected (CDVA) distance visual acuity was registered months operation KC stages. In II, NCOZ EOC greater, from 0.39 ± 0.14 to 0.61 0.18 by 0.22 0.04 (p < 0.05) 0.60 0.15 0.77 0.12 0.17 0.03 0.05), respectively, III. — 0.23 0.07 0.45 0.10 0.53 0.02 due decreased refractive indices central 3.0 mm zone. Refractive indexes zone, UVA CVA all one, two three years, as well data minimal thickness did not change statistically significantly during entire observation period.

Язык: Английский

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“Important Players” in the Development of Age-Related Cataracts (Literature Review)

Ophthalmology in Russia, Год журнала: 2019, Номер 16(1S), С. 21 - 26

Опубликована: Апрель 22, 2019

Millions people around the world, especially in old age, lose sight because of cataracts. The age-related cataract affects approximately 37 million world annually, and 51 % cases, it is cause poor vision. Relevant importance identifying risk factors for development This literature review devoted to studies examining influence various on lens opacities. paper presents data effect age cataracts, so prevalence cataracts at 52–62 years 5 %, 60–69 — 30 70 older 64 %. Its gender features are highlighted frequency opacities women increases significantly with its appearance coincides estrogen deficiency menopause. Reflected dependence race (revealed a higher Asian populations compared population Western countries). also had showed lifestyle bad habits occurrence It was found that smokers have an increased nuclear and, lesser extent, cortical type. noted opacification influenced by amount alcohol consumed, increasing when studying individual types shown consumption strong drinks wine associated cloudiness. Presents from large cohort compare (using odds ratios confidence intervals) association such somatic diseases as diabetes mellitus, hypertension, body mass index some medications.

Язык: Английский

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Using ultraviolet corneal crosslinking for the treatment of corneal ulcers and other corneal pathologies in animals

Russian Ophthalmological Journal, Год журнала: 2019, Номер 12(3), С. 51 - 57

Опубликована: Авг. 31, 2019

Purpose . To study the effects of corneal collagen cross-linking (CCL) using ultraviolet-A (UVA) irradiation with riboflavin on eye’s anterior segment structures in ulcers and other keratopathies animals. Material methods. The involved 26 animals (39 eyes) — 10 cats, dogs, 6 horses ulcers, staphyloma, dry autoimmune keratoconjunctivitis. Examination included slit-lamp biomicroscopy, ophthalmoscopy (in cases transparent cornea), tear production test, staining eye surface vital dyes. CCL was performed UVA radiation LEDs a fiber optic output (wavelength 370 nm, power 3 mW/cm2) combined 0.1 % instillation according to protocol we developed, which specifies various numbers durations depending diagnosis therapeutic effect desired. Results. Restoration shape transparency cornea, relief inflammation, normalization occurred much sooner than traditional treatment. restoration vision 2 months earlier eyes staphyloma; more 4 5 keratoconjunctivitis; no relapses were noted ulcerative processes, function stratified squamous epithelium achieved within or weeks. Conclusions. inclusion modified UFA-based treatment scheme staphylomas as well keratoconjunctivitis enables high structure restoration. In future, results obtained could serve basis for developed technology similar pathologies humans.

Язык: Английский

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Etiopathogenesis of non-exudative age-related macular degeneration (literature review)

Acta Biomedica Scientifica (East Siberian Biomedical Journal), Год журнала: 2022, Номер 7(1), С. 96 - 105

Опубликована: Март 18, 2022

The article presents an overview of modern publications on epidemiology, risk factors, and the main links etiology pathogenesis age-related macular degeneration (AMD). nonexudative or “dry” form is a multifactorial progressive pathological process caused by hereditary predisposition, general local disorders lipid metabolism, negative changes in blood supply to eye, destruction Bruch’s membrane retinal pigment epithelium, appearance signs systemic inflammation, development oxidative stress with impact toxic lipoperoxidation products structures posterior segment eye. Recent studies have discovered new ways epithelial cell death response AMD, particular necroptosis, which, addition classical apoptosis, considered mechanism this process. It noted that AMD may be associated decrease level estrogen women. analysis data etiopathogenesis presented literature indicates need for further research generalization processes developing dynamics visual function specialists various scientific disciplines.

Язык: Английский

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Efficiency and safety of the Russian-made KERATOLINK device used to treat patients with stage I–II keratoconus and pellucid marginal corneal degeneration

Russian Ophthalmological Journal, Год журнала: 2024, Номер 17(3), С. 66 - 73

Опубликована: Окт. 2, 2024

Ultraviolet cross-linking (UVCL) of corneal collagen is one the leading methods for treating primary progressive keratectasia. Purpose : to evaluate effectiveness and safety a new Russian-produced device UVCL, KERATOLINK, in patients with stage I–II keratoconus pellucid marginal degeneration (PMCD). Material . UVCL was performed 36 (46 eyes) aged 18 35 years, including 22 (30 14 (16 PMCD. Three programs were used: 1 — standard radiation intensity from 2.5 3.0 mW/cm2 30-minute exposure time (8 patients, 10 eyes); 2 accelerated 1: 8.0 9.0 min (20 25 3 16.0 18.0 5-minute 11 eyes). The examined before then week, 1, 3, 6 months after it. examination included vision acuity, autorefkeratometry, biomicroscopy, Scheimpflug analysis on Galilei G6 (Ziemer, Switzerland), optical coherence tomography cornea (Anterion, Heidelberg Engineering, Germany), aberrometry (OPD-scan III, Nidek, Japan), confocal biomicroscopy (ConfoScan 4, determination biomechanical parameters - resistance factor (CRF) hysteresis (CH) an ORA (Reichert Inc., USA). Results increase visual acuity 0.56 ± 0.16 0.68 0.13 noted I-II keratoconus, 0.66 0.17 0.75 0.14 (p < 0.05) Flattening at steepest point increased 54.46 4.39 52.87 4.26 D 52.64 2.88 51.53 2.84 D, while rigidity CRF 6.93 1.00 8.38 mm Hg 8.02 9.13 0.97 Hg. 0.03), CH 7.64 0.47 8.61 0.73 6.89 1.20 8.17 0.90 0.05). various revealed no difference recovery period showed comparable clinical functional results. Conclusion KERATOLINK shown be effective safe treatment A decrease ophthalmometry indicators, indicate improvement properties patients’ stabilization pathological process. use local algorithms significant reduced improves comfort tolerability procedure, also reduces risk complications. provides personalized approach due manual stationary options, availability programs, providing choice power duration smooth adjustment fixation size area treatment. laser focal length control system ensures maintenance required regardless impact spot. It has good prospects practice.

Язык: Английский

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Efficiency and Safety of the Domestic Device KERATOLINK for the Treatment of Patients with Bacterial Corneal Ulcers

Ophthalmology in Russia, Год журнала: 2024, Номер 21(3), С. 502 - 508

Опубликована: Окт. 2, 2024

Ultraviolet cross-linking (CXL) of corneal collagen is one the promising methods for treating bacterial ulcers. Purpose work : to evaluate effectiveness and safety use a new domestic device CXL KERATOLINK in treatment patients with ulcer. Materials . Local was performed 24 (24 eyes) aged from 18 74 years, who made up main group. The comparison group included 10 same age To treat ulcerative lesions, drug therapy (antibacterial, corticosteroid, tear replacement reparative) used both groups, but also procedure 5 minutes using “accelerated 2 — ACL 2” program. Each patient underwent 3 procedures an interval days. Ophthalmological examination before treatment, days after 1st, 2nd 3rd procedures, as well 1, 3, 6 months completion visometry, tonometry, microbiological discharge, determination size defect, optical coherence tomography anterior department eye (OCT-AS). examined at time set methods. Results. All were completed without complications, no adverse events identified, all cases recovery period uneventful. CXL, average uncorrected visual acuity increased 0.029 ± 0.026 0.195 0.175. Already third procedure, there absence microorganisms cultures, significant decrease area depth defect (associated its almost complete epithelization) inflammatory edema according OCT-АS data. epithelization 12 Subsequently, stable healing observed months, relapses detected. In group, on 15th day observation, epithelialization achieved only 40% patients. Conclusion. technically simple, minimally invasive method A reduction increase indicate accelerated procedure. local protocol exposure helps comfort tolerability reduce risk complications.

Язык: Английский

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