Gut microbiota in post-acute COVID-19 syndrome: not the end of the story DOI Creative Commons

Yaping An,

Linlin He,

Xin Xu

и другие.

Frontiers in Microbiology, Год журнала: 2024, Номер 15

Опубликована: Дек. 24, 2024

The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has led to major global health concern. However, the focus on immediate effects was assumed as tip of iceberg due symptoms following infection, which defined post-acute COVID-19 (PACS). Gut microbiota alterations even after resolution and gastrointestinal are key features PACS. derived metabolites disorders may play a crucial role in inflammatory immune response SARS-CoV-2 infection through gut-lung axis. Diet is one modifiable factors closely related gut COVID-19. In this review, we described reciprocal crosstalk between lung, highlighting participation diet destroying barrier, perturbing metabolism regulating system. Therefore, bolstering beneficial species dietary supplements, probiotics or prebiotics fecal transplantation (FMT) be novel avenue for PACS prevention. This review provides better understanding association long-term consequences COVID-19, indicates modulating dysbiosis potentiality addressing multifaceted condition.

Язык: Английский

Risk of long covid in patients with pre-existing chronic respiratory diseases: a systematic review and meta-analysis DOI Creative Commons
Paul Terry, R. Eric Heidel, Alexandria Quesenberry

и другие.

BMJ Open Respiratory Research, Год журнала: 2025, Номер 12(1), С. e002528 - e002528

Опубликована: Янв. 1, 2025

Background An estimated 10–30% of people with COVID-19 experience debilitating long-term symptoms or long covid. Underlying health conditions associated chronic inflammation may increase the risk Methods We conducted a systematic review and meta-analysis to examine whether covid was altered by pre-existing asthma obstructive pulmonary disease (COPD) in adults. identified studies searching PubMed Embase databases from inception 13 September 2024. excluded that focused on children defined only terms respiratory symptoms. used random-effects, restricted maximum likelihood models analyse data pooled 51 studies, which included 43 analyses 30 COPD. The bias assessed using ROBINS-E table. Results found 41% increased odds (95% CI 1.29 1.54); COPD 32% 1.16 1.51). Pre-existing asthma, but not COPD, covid-associated fatigue. observed heterogeneity results related hospitalisation status. Potential confounding inconsistent measurement exposure outcome variables were among limitations. Conclusions Our findings support hypothesis covid, including fatigue outcomes patients asthma. Because targets tract, these inflammatory lower tract could provide mechanistic clues common pathway for development sequelae

Язык: Английский

Процитировано

3
The future of pharmaceuticals: Artificial intelligence in drug discovery and development DOI Creative Commons
Chen Fu, Qi Chen

Journal of Pharmaceutical Analysis, Год журнала: 2025, Номер unknown, С. 101248 - 101248

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1
Post COVID-19 among young adults– prevalence and associations with general health, stress, and lifestyle factors DOI Creative Commons
Sandra Ekström, Ida Mogensen, Maria Ödling

и другие.

BMC Public Health, Год журнала: 2025, Номер 25(1)

Опубликована: Апрель 9, 2025

Язык: Английский

Процитировано

1
Viral Variants, Vaccinations, and Long Covid — New Insights DOI
Clifford J. Rosen

New England Journal of Medicine, Год журнала: 2024, Номер 391(6), С. 561 - 562

Опубликована: Июль 17, 2024

Язык: Английский

Процитировано

7
Translating insights into therapies for Long Covid DOI Open Access
Annukka A.R. Antar, Andrea L. Cox

Science Translational Medicine, Год журнала: 2024, Номер 16(773)

Опубликована: Ноя. 13, 2024

Long Covid is defined by a wide range of symptoms that persist after the acute phase severe respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Commonly reported include fatigue, weakness, postexertional malaise, and cognitive dysfunction, with many other reported. Symptom range, duration, severity are highly variable partially overlap myalgic encephalomyelitis/chronic fatigue post-acute infectious syndromes, highlighting opportunities to define shared mechanisms pathogenesis. Potential diverse, including persistence viral reservoirs, dysregulated immune responses, direct damage tissues targeted SARS-CoV-2, inflammation driven reactivation latent infections, vascular endothelium activation or subsequent thromboinflammation, autoimmunity, metabolic derangements, microglial activation, microbiota dysbiosis. The heterogeneity baseline characteristics people Covid, as well varying states immunity therapies given at time infection, have made etiologies difficult determine. Here, we examine progress on preclinical models for review being in clinical trials, need large human studies further development better understand Covid. Such will inform trials treatments benefit those living this condition.

Язык: Английский

Процитировано

5
Post-acute sequelae of COVID-19 in people of Black ethnicities living with HIV in the United Kingdom DOI
Zoë Ottaway, Lucy Campbell, Julie Fox

и другие.

International Journal of STD & AIDS, Год журнала: 2025, Номер unknown

Опубликована: Апрель 14, 2025

Background The COVID-19 pandemic disproportionately affected people of Black ethnicities, however, there are limited data on the post-acute sequelae infection in these populations, and none those with HIV. Methods We conducted a cross-sectional study ethnicities HIV UK. Participants were assessed for functional impairment, frailty, respiratory symptoms, anxiety depression; they also asked to rate aspects their physical mental health scale from 1 (poor) 10 (excellent), both at enrolment prior pandemic. report associations history recovery status. Results enrolled 183 participants between June 2021 October 2022, 131 (72%) whom reported COVID-19. A was associated reduced ability carry out usual activities (OR 2.54 [1.03–6.21], p = 0.04), an increase pain, tiredness breathlessness, overall decline health. Of COVID-19, 111 (85%) have fully recovered. Those who had not recovered poorer status ( < 0.001) higher generalised scores 0.02). Objective measures function similar no full recovery, incomplete recovery. Conclusions In this cohort HIV, daily living various other issues. Although most self-reported limitations common sequelae.

Язык: Английский

Процитировано

0
Relationship of Non-Invasive Arterial Stiffness Parameters with 10-Year Atherosclerotic Cardiovascular Disease Risk Score in Post-COVID-19 Patients—The Results of a Cross-Sectional Study DOI Creative Commons
Danuta Łoboda, Beata Sarecka‐Hujar, Marta Nowacka-Chmielewska

и другие.

Life, Год журнала: 2024, Номер 14(9), С. 1105 - 1105

Опубликована: Сен. 2, 2024

This study evaluated the relationship of non-invasive arterial stiffness parameters with an individual 10-year risk fatal and non-fatal atherosclerotic cardiovascular disease (ASCVD) events in cohort post-coronavirus 2019 (COVID-19). The group included 203 convalescents aged 60.0 (55.0–63.0) 115 (56.7%) women. ASCVD was assessed as low to moderate very high based on medical history (for 62 participants pre-existing ASCVD/diabetes/chronic kidney entire cohort) or calculated percentages using Systemic Coronary Risk Evaluation 2 (SCORE2) algorithm age, sex, smoking status, systolic blood pressure (BP), non-high-density lipoprotein cholesterol 141 healthy participants). index (SI) reflection (RI) measured by photoplethysmography, well pulse (PP), difference between diastolic BP, were markers stiffness. Stiffness increased significantly increase cohort. In 30 (14.8%) patients low- moderate-risk group, median SI 8.07 m/s (7.10–8.73), RI 51.40% (39.40–65.60), PP 45.50 mmHg (40.00–57.00); 111 (54.7%) high-risk 8.70 (7.40–10.03), 57.20% (43.65–68.40), 54.00 (46.00–60.75); (30.5%) very-high-risk 9.27 (7.57–10.44), 59.00% (50.40–72.40), 60.00 (51.00–67.00). participants, ≤ 9.0 (sensitivity 92.31%, area under curve [AUC] 0.686, p < 0.001) receiver operating characteristics most sensitive variable for discriminating risk, > 56.0 74.36%, AUC 0.736, used risk. multivariate logistic regression, younger female 50 mmHg, m/s, triglycerides 150 mg/dL had best SCORE2 turn, older currently smoking, 68.6%, BP ≥ 90 related conclusion, is post-COVID-19 can be helpful a single marker everyday practice. Cut-off points determined may help make decisions about implementing lifestyle changes pharmacological treatment factors

Язык: Английский

Процитировано

3
Long-term mitochondrial and metabolic impairment in lymphocytes of subjects who recovered after severe COVID-19 DOI Creative Commons
Irene Gómez Delgado, Andrea R. López‐Pastor, Adela González-Jiménez

и другие.

Cell Biology and Toxicology, Год журнала: 2025, Номер 41(1)

Опубликована: Янв. 10, 2025

The underlying mechanisms explaining the differential course of SARS-CoV-2 infection and potential clinical consequences after COVID-19 resolution have not been fully elucidated. As a dysregulated mitochondrial activity could impair immune response, we explored long-lasting changes in functionality, circulating cytokine levels, metabolomic profiles infected individuals symptoms resolution, to evaluate whether complete recovery be achieved. Results this pilot study evidenced that different parameters aerobic respiration lymphocytes recuperated from severe lagged behind those shown upon mild recovery, basal conditions simulated reinfection, they also showed altered glycolytic capacity. groups trends enhanced superoxide production parallel lower OPA1-S levels. Unbalance pivotal fusion (MFN2, OPA1) fission (DRP1, FIS1) proteins was detected, suggesting disruption dynamics, as well lack structural integrity electron transport chain. In serum, levels IL-1β, IFN-α2, IL-27 persisted long growing amounts latter correlated with maximal respiration, ATP production, Finally, trend for higher 3-hydroxybutyrate found recovered compared course. summary, acute infection, metabolic seem differ situation full versus one evolving infection.

Язык: Английский

Процитировано

0
Post infectious fatigue and circadian rhythm disruption in long-COVID and other infections: a need for further research DOI Creative Commons

Achilleas Livieratos,

Steven W. Lockley, Sotirios Tsiodras

и другие.

EClinicalMedicine, Год журнала: 2025, Номер 80, С. 103073 - 103073

Опубликована: Янв. 18, 2025

Язык: Английский

Процитировано

0
Animal Models for Long COVID: Current Advances, Limitations, and Future Directions DOI
Yu Zhang, Huan Chen, Yumeng Li

и другие.

Journal of Medical Virology, Год журнала: 2025, Номер 97(2)

Опубликована: Фев. 1, 2025

ABSTRACT Long COVID (LC) represents a chronic, systemic, and often disabling condition that poses significant ongoing threat to public health. Foundational scientific studies are needed unravel the underlying mechanisms, with ultimate goal of developing effective preventative therapeutic strategies. Therefore, there is an urgent demand for animal models can accurately replicate clinical features LC. This review integrates epidemiological data summarize pathological changes in extrapulmonary systems involved Additionally, it critically examines capacity existing models, including nonhuman primates, genetically modified mice, Syrian hamsters, exhibit enduring postinfection symptoms align human manifestations, identifies key areas requiring further development. The objective offer insights will aid development next‐generation thereby accelerating our understanding how acute respiratory viral infections transition into chronic conditions, ensuring preparedness future pandemics.

Язык: Английский

Процитировано

0