Gut microbiota in post-acute COVID-19 syndrome: not the end of the story DOI Creative Commons

Yaping An,

Linlin He,

Xin Xu

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 24, 2024

The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has led to major global health concern. However, the focus on immediate effects was assumed as tip of iceberg due symptoms following infection, which defined post-acute COVID-19 (PACS). Gut microbiota alterations even after resolution and gastrointestinal are key features PACS. derived metabolites disorders may play a crucial role in inflammatory immune response SARS-CoV-2 infection through gut-lung axis. Diet is one modifiable factors closely related gut COVID-19. In this review, we described reciprocal crosstalk between lung, highlighting participation diet destroying barrier, perturbing metabolism regulating system. Therefore, bolstering beneficial species dietary supplements, probiotics or prebiotics fecal transplantation (FMT) be novel avenue for PACS prevention. This review provides better understanding association long-term consequences COVID-19, indicates modulating dysbiosis potentiality addressing multifaceted condition.

Language: Английский

Risk of long covid in patients with pre-existing chronic respiratory diseases: a systematic review and meta-analysis DOI Creative Commons
Paul Terry, R. Eric Heidel, Alexandria Quesenberry

et al.

BMJ Open Respiratory Research, Journal Year: 2025, Volume and Issue: 12(1), P. e002528 - e002528

Published: Jan. 1, 2025

Background An estimated 10–30% of people with COVID-19 experience debilitating long-term symptoms or long covid. Underlying health conditions associated chronic inflammation may increase the risk Methods We conducted a systematic review and meta-analysis to examine whether covid was altered by pre-existing asthma obstructive pulmonary disease (COPD) in adults. identified studies searching PubMed Embase databases from inception 13 September 2024. excluded that focused on children defined only terms respiratory symptoms. used random-effects, restricted maximum likelihood models analyse data pooled 51 studies, which included 43 analyses 30 COPD. The bias assessed using ROBINS-E table. Results found 41% increased odds (95% CI 1.29 1.54); COPD 32% 1.16 1.51). Pre-existing asthma, but not COPD, covid-associated fatigue. observed heterogeneity results related hospitalisation status. Potential confounding inconsistent measurement exposure outcome variables were among limitations. Conclusions Our findings support hypothesis covid, including fatigue outcomes patients asthma. Because targets tract, these inflammatory lower tract could provide mechanistic clues common pathway for development sequelae

Language: Английский

Citations

3
The future of pharmaceuticals: Artificial intelligence in drug discovery and development DOI Creative Commons
Chen Fu, Qi Chen

Journal of Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 101248 - 101248

Published: Feb. 1, 2025

Language: Английский

Citations

1
Viral Variants, Vaccinations, and Long Covid — New Insights DOI
Clifford J. Rosen

New England Journal of Medicine, Journal Year: 2024, Volume and Issue: 391(6), P. 561 - 562

Published: July 17, 2024

Language: Английский

Citations

7
Translating insights into therapies for Long Covid DOI Open Access
Annukka A.R. Antar, Andrea L. Cox

Science Translational Medicine, Journal Year: 2024, Volume and Issue: 16(773)

Published: Nov. 13, 2024

Long Covid is defined by a wide range of symptoms that persist after the acute phase severe respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Commonly reported include fatigue, weakness, postexertional malaise, and cognitive dysfunction, with many other reported. Symptom range, duration, severity are highly variable partially overlap myalgic encephalomyelitis/chronic fatigue post-acute infectious syndromes, highlighting opportunities to define shared mechanisms pathogenesis. Potential diverse, including persistence viral reservoirs, dysregulated immune responses, direct damage tissues targeted SARS-CoV-2, inflammation driven reactivation latent infections, vascular endothelium activation or subsequent thromboinflammation, autoimmunity, metabolic derangements, microglial activation, microbiota dysbiosis. The heterogeneity baseline characteristics people Covid, as well varying states immunity therapies given at time infection, have made etiologies difficult determine. Here, we examine progress on preclinical models for review being in clinical trials, need large human studies further development better understand Covid. Such will inform trials treatments benefit those living this condition.

Language: Английский

Citations

5
Long-term mitochondrial and metabolic impairment in lymphocytes of subjects who recovered after severe COVID-19 DOI Creative Commons
Irene Gómez Delgado, Andrea R. López‐Pastor, Adela González-Jiménez

et al.

Cell Biology and Toxicology, Journal Year: 2025, Volume and Issue: 41(1)

Published: Jan. 10, 2025

The underlying mechanisms explaining the differential course of SARS-CoV-2 infection and potential clinical consequences after COVID-19 resolution have not been fully elucidated. As a dysregulated mitochondrial activity could impair immune response, we explored long-lasting changes in functionality, circulating cytokine levels, metabolomic profiles infected individuals symptoms resolution, to evaluate whether complete recovery be achieved. Results this pilot study evidenced that different parameters aerobic respiration lymphocytes recuperated from severe lagged behind those shown upon mild recovery, basal conditions simulated reinfection, they also showed altered glycolytic capacity. groups trends enhanced superoxide production parallel lower OPA1-S levels. Unbalance pivotal fusion (MFN2, OPA1) fission (DRP1, FIS1) proteins was detected, suggesting disruption dynamics, as well lack structural integrity electron transport chain. In serum, levels IL-1β, IFN-α2, IL-27 persisted long growing amounts latter correlated with maximal respiration, ATP production, Finally, trend for higher 3-hydroxybutyrate found recovered compared course. summary, acute infection, metabolic seem differ situation full versus one evolving infection.

Language: Английский

Citations

0
Long COVID in a highly vaccinated but largely unexposed Australian population following the 2022 SARS‐CoV‐2 Omicron wave DOI Open Access
Mulu Abraha Woldegiorgis, Rosemary Korda, Paul V. Effler

et al.

The Medical Journal of Australia, Journal Year: 2025, Volume and Issue: unknown

Published: March 9, 2025

Language: Английский

Citations

0
Post COVID-19 among young adults– prevalence and associations with general health, stress, and lifestyle factors DOI Creative Commons
Sandra Ekström, Ida Mogensen, Maria Ödling

et al.

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 9, 2025

Language: Английский

Citations

0
Post-acute sequelae of COVID-19 in people of Black ethnicities living with HIV in the United Kingdom DOI
Zoë Ottaway, Lucy Campbell, Julie Fox

et al.

International Journal of STD & AIDS, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Background The COVID-19 pandemic disproportionately affected people of Black ethnicities, however, there are limited data on the post-acute sequelae infection in these populations, and none those with HIV. Methods We conducted a cross-sectional study ethnicities HIV UK. Participants were assessed for functional impairment, frailty, respiratory symptoms, anxiety depression; they also asked to rate aspects their physical mental health scale from 1 (poor) 10 (excellent), both at enrolment prior pandemic. report associations history recovery status. Results enrolled 183 participants between June 2021 October 2022, 131 (72%) whom reported COVID-19. A was associated reduced ability carry out usual activities (OR 2.54 [1.03–6.21], p = 0.04), an increase pain, tiredness breathlessness, overall decline health. Of COVID-19, 111 (85%) have fully recovered. Those who had not recovered poorer status ( < 0.001) higher generalised scores 0.02). Objective measures function similar no full recovery, incomplete recovery. Conclusions In this cohort HIV, daily living various other issues. Although most self-reported limitations common sequelae.

Language: Английский

Citations

0
The Conditions of Survival of Patients with a SARS-CoV-2 Infection Burdened by Cardiovascular Pathologies in a Temporary Hospital in Gdańsk in 2021 and 2022 DOI Open Access
Dariusz Kostrzewa, Anna Justyna Milewska, Petre Iltchev

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(8), P. 2806 - 2806

Published: April 18, 2025

A detailed analysis was carried out on the impact of cardiovascular disease risk death patients hospitalized at a temporary hospital in Gdańsk during third and fifth waves COVID-19 pandemic (in 2021 2022, respectively). Background/Objectives: The documentation 1244 analyzed, which 701 were (the Delta variant) 543 2022 Omicron variant). aim this study to assess with depending co-existence diseases. Methods: model logistic regression used identify patients’ age, coexistence disease, length hospitalization death. Results: In 2021, younger (median 66 years) than 74 years), shorter (9 days) (11 days), there higher proportion respiratory diseases medical history cancer 2022. odds also observed be older particularly those under 73 years age. (over paradoxically reduced. Conclusions: age patient, duration affect variant (2021) more virulent (2022). Cardiovascular significantly increases COVID-19. comprehensive diagnosis treatment these conditions may reduce mortality. Further studies are needed long-term effects system.

Language: Английский

Citations

0
Risk of post-acute symptoms among adults: A comparison study of severe COVID-19, pneumonia, and influenza DOI Creative Commons
Caroline Schaefer, Trudy Millard Krause, George L. Delclos

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(4), P. e0322020 - e0322020

Published: April 29, 2025

Background A retrospective cohort study was undertaken to assess the relationship between initial disease severity of COVID-19 and risk post-acute symptoms. The compared against influenza pneumonia cohorts whether symptoms differed. Methods Administrative health claims data were obtained for commercially insured Medicare Advantage covered adults ( ≥ 18 years) with symptomatic laboratory-confirmed diagnosed in 2020 (n=121,205), similar (n=20,844) (n=29,052) patients prior pandemic. Post-acute assessed at four weeks, three six months following diagnosis. Results Among COVID-19, likelihood any symptom increased severity, also influenced by presence comorbidities, especially rheumatoid arthritis, ischemic heart asthma. specific varied age, risks anxiety headache among young, whereas elderly experienced brain fog fatigue. When cohorts, all groups symptoms, a strong only partial resolution over six-month observation period. Those less likely than those experience while more have illness COVID-19. Conclusions Using large national dataset, we found that symptomology could not be described previously seen or differences exist prevalence as well time resolution, better characterizing “long COVID” identifying these are unique

Language: Английский

Citations

0