Relationship between physical activity and DNA methylation-predicted epigenetic clocks
npj Aging,
Год журнала:
2025,
Номер
11(1)
Опубликована: Апрель 12, 2025
This
study
investigates
the
relationship
between
physical
activity
(PA)
levels
and
DNA
methylation
(DNAm)-predicted
epigenetic
clocks
in
a
U.S.
population
sample
(n
=
948,
mean
age
62,
49%
female).
Eight
were
analyzed,
revealing
that
higher
PA
significantly
associated
with
younger
biological
ages
across
all
indicators,
strongest
effects
observed
for
SkinBloodAge
LinAge.
Multivariable
linear
regression
models,
adjusted
sociodemographic
lifestyle
factors,
highlighted
potential
of
to
reduce
ageing.
Subgroup
analyses
indicated
these
associations
more
pronounced
among
non-Hispanic
whites,
individuals
BMI
25-30,
former
smokers,
suggesting
impact
varies
different
groups.
These
findings
emphasize
role
slowing
ageing
reducing
age-related
health
risks.
Promoting
regular
PA,
especially
older
adults
those
BMI,
could
improve
well-being
lifespan,
highlighting
as
modifiable
factor
healthy
disease
prevention.
Язык: Английский
Common DNA sequence variation influences epigenetic aging in African populations
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 26, 2024
Abstract
Aging
is
associated
with
genome-wide
changes
in
DNA
methylation
humans,
facilitating
the
development
of
epigenetic
age
prediction
models.
However,
most
these
models
have
been
trained
primarily
on
European-ancestry
individuals,
and
none
account
for
impact
quantitative
trait
loci
(meQTL).
To
address
gaps,
we
analyzed
relationships
between
age,
genotype,
CpG
3
understudied
populations:
central
African
Baka
(n
=
35),
southern
‡Khomani
San
52),
Himba
51).
We
find
that
published
methods
yield
higher
mean
errors
cohorts
compared
to
unaccounted-for
sequence
variation
may
be
a
significant
factor
underlying
this
loss
accuracy.
leverage
information
about
associations
genotype
develop
an
predictor
minimally
influenced
by
meQTL,
show
model
remains
accurate
across
broad
range
genetic
backgrounds.
Intriguingly,
also
older
individuals
those
exhibiting
relatively
lower
acceleration
our
tend
carry
more
age-reducing
variants,
suggesting
novel
mechanism
which
heritable
factors
can
influence
longevity.
Язык: Английский
Advancing Health Disparities Science Through Social Epigenomics Research
JAMA Network Open,
Год журнала:
2024,
Номер
7(7), С. e2428992 - e2428992
Опубликована: Июль 29, 2024
Importance
Although
scientific
and
technological
discoveries
have
improved
the
health
of
US
population
overall,
racial
ethnic
minority
(American
Indian
Alaska
Native,
Asian,
Black
or
African
American,
Hispanic
Latino,
Native
Hawaiian
Pacific
Islander
persons)
socioeconomically
disadvantaged
populations
continue
to
experience
a
disproportionate
burden
disease
other
adverse
conditions.
To
better
understand
address
drivers
disparities
inform
development
effective
interventions,
integrative
mechanistic
studies
examining
dynamic
interplay
multiple
factors
across
life
course
even
between
generations
are
needed.
The
emerging
field
social
epigenomics,
which
seeks
link
stressors
protective
status
through
examination
epigenomic
modifications
various
biological
pathways,
is
one
promising
area
research
contributing
this
need.
Observations
This
thematic
issue
JAMA
Network
Open
highlights
new
findings
from
grantees
National
Institutes
Health
(NIH)
Social
Epigenomics
Program.
These
findings,
taken
together,
examine
associations
variety
social,
behavioral,
structural
throughout
with
changes
among
experiencing
disparities.
early-life
exposures,
inequities,
behavioral
interventions
epigenetic
changes,
in
some
studies,
later
outcomes.
While
there
still
more
work
be
done
fully
characterize
pathways
linking
exposures
outcomes,
body
presented
special
represents
solid
progress
toward
goal.
Conclusions
Relevance
highlighted
demonstrate
important
complex
integration
determinants
outcomes
improve
understanding
mechanisms
underlying
underserved
populations.
Continued
remains
integrating
different
disciplines
transform
research.
Язык: Английский
The Short-term and Long-term Effects of the COVID-19 Pandemic on Public Interest in Physical Activities in China (Preprint)
Опубликована: Сен. 4, 2024
BACKGROUND
Physical
activity
is
a
critical
component
of
public
health,
offering
numerous
benefits
for
physical
and
mental
well-being.
However,
the
COVID-19
pandemic
related
control
measures
have
dramatically
altered
daily
life,
potentially
impacting
interest
in
different
forms
activities
corresponding
exercise
habits.
Understanding
how
has
changed
during
various
phases
essential
developing
strategies
to
promote
maintain
health
population.
OBJECTIVE
To
evaluate
short-term
long-term
effects
on
within
China,
utilizing
internet
search
data
as
an
indicator.
METHODS
This
study
utilized
volume
spanning
from
January
1,
2019,
December
31,
2023,
track
changes
across
three
phases:
pre-pandemic,
during-pandemic,
post-pandemic.
It
specifically
focused
types
activities,
categorized
outdoor
exercises,
home
gym-based
exercises.
By
employing
multivariate
linear
regression
fixed
models,
research
aimed
quantitatively
analyze
these
varied
throughout
assess
influence
severity
changes.
RESULTS
After
accounting
cyclical
factors,
significant
shifts
volumes
were
observed
activities.
During
pandemic,
Home
Exercises
surged
by
2,759.088
(95%
CI,
2310.236
3207.939;
P
<
0.001),
while
Outdoor
Gym-based
saw
declines
562.160
-623.406
-500.914;
0.001)
478.895
-507.373
-450.416;
respectively.
Post-pandemic,
searches
further
decreased
all
categories:
478.254
-553.274
-403.235;
=
0.003),
1,115.101
-1664.892
-565.310;
0.008),
752.718
-787.601
-717.835;
compared
2019
levels.
Additionally,
impacted
negatively
most
periods
categories.
CONCLUSIONS
The
had
lasting
negative
effect
with
clear
dose-response
relationship
that
correlates
outbreak.
These
findings
underscore
need
tailored
initiatives
adapted
regions
enhance
outcomes.
Язык: Английский
Progression of Dopaminergic Therapy Changes in Parkinson's Disease in Asian and Native Hawaiian and Pacific Islander Populations
Movement Disorders Clinical Practice,
Год журнала:
2024,
Номер
12(2), С. 255 - 257
Опубликована: Ноя. 18, 2024
The
data
that
support
the
findings
of
this
study
are
available
from
corresponding
author
upon
reasonable
request.
Язык: Английский
Blood-based sex-differential DNA methylation in Alzheimer’s disease
Ageing and Neurodegenerative Diseases,
Год журнала:
2024,
Номер
4(4)
Опубликована: Дек. 13, 2024
Aim:
We
aim
to
explore
the
blood-based
sex-differential
DNA
methylation
profiles
in
patients
with
Alzheimer’s
disease
(AD).
Methods:
The
same
analytical
pipeline
and
meta-analysis
procedure
were
applied
254
AD
261
matched
healthy
controls
(HC)
from
four
datasets
identify
sex-differentially
methylated
positions
(sex-DMPs)
their
biological
functions.
further
reviewed
brain-based
sex-DMPs
previously
reported
intersected
sex-DMPs.
Results:
identified
134
AD,
88
unique
46
shared
HC.
Eleven
novel
28
consistent
across
blood
brain
recognized
for
first
time.
Differentially
genes,
such
as
COL25A1
,
MSUT2
ELAVL4
SLC17A7
EPHA4
PPP2CB
closely
related
pathogenesis
of
AD.
In
addition,
immune-related
processes
enriched
enrichment
analysis.
Conclusion:
Sex-differential
provides
potential
biomarkers
pathogenesis,
also
points
drug
targets
precision
medicine.
Язык: Английский