Relationship between physical activity and DNA methylation-predicted epigenetic clocks

npj Aging, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 12, 2025

This study investigates the relationship between physical activity (PA) levels and DNA methylation (DNAm)-predicted epigenetic clocks in a U.S. population sample (n = 948, mean age 62, 49% female). Eight were analyzed, revealing that higher PA significantly associated with younger biological ages across all indicators, strongest effects observed for SkinBloodAge LinAge. Multivariable linear regression models, adjusted sociodemographic lifestyle factors, highlighted potential of to reduce ageing. Subgroup analyses indicated these associations more pronounced among non-Hispanic whites, individuals BMI 25-30, former smokers, suggesting impact varies different groups. These findings emphasize role slowing ageing reducing age-related health risks. Promoting regular PA, especially older adults those BMI, could improve well-being lifespan, highlighting as modifiable factor healthy disease prevention.

Language: Английский

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Common DNA sequence variation influences epigenetic aging in African populations

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 26, 2024

Abstract Aging is associated with genome-wide changes in DNA methylation humans, facilitating the development of epigenetic age prediction models. However, most these models have been trained primarily on European-ancestry individuals, and none account for impact quantitative trait loci (meQTL). To address gaps, we analyzed relationships between age, genotype, CpG 3 understudied populations: central African Baka (n = 35), southern ‡Khomani San 52), Himba 51). We find that published methods yield higher mean errors cohorts compared to unaccounted-for sequence variation may be a significant factor underlying this loss accuracy. leverage information about associations genotype develop an predictor minimally influenced by meQTL, show model remains accurate across broad range genetic backgrounds. Intriguingly, also older individuals those exhibiting relatively lower acceleration our tend carry more age-reducing variants, suggesting novel mechanism which heritable factors can influence longevity.

Language: Английский

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Advancing Health Disparities Science Through Social Epigenomics Research

JAMA Network Open, Journal Year: 2024, Volume and Issue: 7(7), P. e2428992 - e2428992

Published: July 29, 2024

Importance Although scientific and technological discoveries have improved the health of US population overall, racial ethnic minority (American Indian Alaska Native, Asian, Black or African American, Hispanic Latino, Native Hawaiian Pacific Islander persons) socioeconomically disadvantaged populations continue to experience a disproportionate burden disease other adverse conditions. To better understand address drivers disparities inform development effective interventions, integrative mechanistic studies examining dynamic interplay multiple factors across life course even between generations are needed. The emerging field social epigenomics, which seeks link stressors protective status through examination epigenomic modifications various biological pathways, is one promising area research contributing this need. Observations This thematic issue JAMA Network Open highlights new findings from grantees National Institutes Health (NIH) Social Epigenomics Program. These findings, taken together, examine associations variety social, behavioral, structural throughout with changes among experiencing disparities. early-life exposures, inequities, behavioral interventions epigenetic changes, in some studies, later outcomes. While there still more work be done fully characterize pathways linking exposures outcomes, body presented special represents solid progress toward goal. Conclusions Relevance highlighted demonstrate important complex integration determinants outcomes improve understanding mechanisms underlying underserved populations. Continued remains integrating different disciplines transform research.

Language: Английский

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The Short-term and Long-term Effects of the COVID-19 Pandemic on Public Interest in Physical Activities in China (Preprint)

Published: Sept. 4, 2024

Physical activity is a critical component of public health, offering numerous benefits for physical and mental well-being. However, the COVID-19 pandemic related control measures have dramatically altered daily life, potentially impacting interest in different forms activities corresponding exercise habits. Understanding how has changed during various phases essential developing strategies to promote maintain health population. To evaluate short-term long-term effects on within China, utilizing internet search data as an indicator. This study utilized volume spanning from January 1, 2019, December 31, 2023, track changes across three phases: pre-pandemic, during-pandemic, post-pandemic. It specifically focused types activities, categorized outdoor exercises, home gym-based exercises. By employing multivariate linear regression fixed models, research aimed quantitatively analyze these varied throughout assess influence severity changes. After accounting cyclical factors, significant shifts volumes were observed activities. During pandemic, Home Exercises surged by 2,759.088 (95% CI, 2310.236 3207.939; P < 0.001), while Outdoor Gym-based saw declines 562.160 -623.406 -500.914; 0.001) 478.895 -507.373 -450.416; respectively. Post-pandemic, searches further decreased all categories: 478.254 -553.274 -403.235; = 0.003), 1,115.101 -1664.892 -565.310; 0.008), 752.718 -787.601 -717.835; compared 2019 levels. Additionally, impacted negatively most periods categories. The had lasting negative effect with clear dose-response relationship that correlates outbreak. These findings underscore need tailored initiatives adapted regions enhance outcomes.

Language: Английский

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Progression of Dopaminergic Therapy Changes in Parkinson's Disease in Asian and Native Hawaiian and Pacific Islander Populations

Movement Disorders Clinical Practice, Journal Year: 2024, Volume and Issue: 12(2), P. 255 - 257

Published: Nov. 18, 2024

The data that support the findings of this study are available from corresponding author upon reasonable request.

Language: Английский

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Blood-based sex-differential DNA methylation in Alzheimer’s disease

Ageing and Neurodegenerative Diseases, Journal Year: 2024, Volume and Issue: 4(4)

Published: Dec. 13, 2024

Aim: We aim to explore the blood-based sex-differential DNA methylation profiles in patients with Alzheimer’s disease (AD). Methods: The same analytical pipeline and meta-analysis procedure were applied 254 AD 261 matched healthy controls (HC) from four datasets identify sex-differentially methylated positions (sex-DMPs) their biological functions. further reviewed brain-based sex-DMPs previously reported intersected sex-DMPs. Results: identified 134 AD, 88 unique 46 shared HC. Eleven novel 28 consistent across blood brain recognized for first time. Differentially genes, such as COL25A1 , MSUT2 ELAVL4 SLC17A7 EPHA4 PPP2CB closely related pathogenesis of AD. In addition, immune-related processes enriched enrichment analysis. Conclusion: Sex-differential provides potential biomarkers pathogenesis, also points drug targets precision medicine.

Language: Английский

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