Brain Research Bulletin,
Год журнала:
2024,
Номер
209, С. 110921 - 110921
Опубликована: Март 4, 2024
Tunneling
nanotubes
(TNTs)
have
emerged
as
pivotal
structures
for
intercellular
communication,
enabling
the
transfer
of
cellular
components
across
distant
cells.
Their
involvement
in
neurological
disorders
has
attracted
considerable
scientific
interest.
This
review
delineates
functions
TNTs
within
central
nervous
system,
examining
their
role
transmission
bioenergetic
substrates,
and
signaling
molecules,
multifaceted
impact
on
both
physiological
pathological
processes,
with
an
emphasis
neurodegenerative
diseases.
The
highlights
selectivity
specificity
dedicated
pathways
cargo
delivery,
particularly
under
stress
conditions
that
provoke
increased
TNT
formation.
potential
therapeutic
targets
is
explored
depth.
We
pay
particular
attention
to
interactions
between
astrocytes
neurons
mediated
by
TNTs,
which
are
fundamental
brain
architecture
function.
Dysfunctions
these
implicated
spread
protein
aggregates
mitochondrial
anomalies,
contributing
pathogenesis
culminates
a
synthesis
current
understanding
biology
identifies
research
gaps,
advocating
intensified
exploration
into
promising
frontier.
Frontiers in Endocrinology,
Год журнала:
2023,
Номер
14
Опубликована: Апрель 3, 2023
Obesity
has
been
associated
with
oxidative
stress.
Obese
patients
are
at
increased
risk
for
diabetic
cognitive
dysfunction,
indicating
a
pathological
link
between
obesity,
stress,
and
dysfunction.
can
induce
the
biological
process
of
stress
by
disrupting
adipose
microenvironment
(adipocytes,
macrophages),
mediating
low-grade
chronic
inflammation,
mitochondrial
dysfunction
(mitochondrial
division,
fusion).
Furthermore,
be
implicated
in
insulin
resistance,
inflammation
neural
tissues,
lipid
metabolism
disorders,
affecting
diabetics.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(4), С. 3739 - 3739
Опубликована: Фев. 13, 2023
Neurodegenerative
diseases
comprise
a
wide
spectrum
of
pathologies
characterized
by
progressive
loss
neuronal
functions
and
structures.
Despite
having
different
genetic
backgrounds
etiology,
in
recent
years,
many
studies
have
highlighted
point
convergence
the
mechanisms
leading
to
neurodegeneration:
mitochondrial
dysfunction
oxidative
stress
been
observed
pathologies,
their
detrimental
effects
on
neurons
contribute
exacerbation
pathological
phenotype
at
various
degrees.
In
this
context,
increasing
relevance
has
acquired
antioxidant
therapies,
with
purpose
restoring
order
revert
damage.
However,
conventional
antioxidants
were
not
able
specifically
accumulate
diseased
mitochondria,
often
eliciting
harmful
whole
body.
last
decades,
novel,
precise,
mitochondria-targeted
(MTA)
compounds
developed
studied,
both
vitro
vivo,
address
need
counter
mitochondria
restore
energy
supply
membrane
potentials
neurons.
review,
we
focus
activity
therapeutic
perspectives
MitoQ,
SkQ1,
MitoVitE
MitoTEMPO,
most
studied
belonging
class
MTA
conjugated
lipophilic
cations,
reach
compartment.
Redox Biology,
Год журнала:
2023,
Номер
67, С. 102871 - 102871
Опубликована: Сен. 7, 2023
Ferroptosis
is
a
newly
discovered
form
of
iron-dependent
oxidative
cell
death
and
drives
the
loss
neurons
in
spinal
cord
injury
(SCI).
Mitochondrial
damage
critical
contributor
to
neuronal
death,
while
mitochondrial
quality
control
(MQC)
an
essential
process
for
maintaining
homeostasis
promote
survival.
However,
role
MQC
ferroptosis
has
not
been
clearly
elucidated.
Here,
we
further
demonstrate
that
primarily
suffer
from
SCI
at
single
sequencing
level.
Mechanistically,
disordered
aggravates
through
excessive
fission
mitophagy.
Furthermore,
mesenchymal
stem
cells
(MSCs)-mediated
transfer
restores
mitochondria
pool
inhibits
fusion
by
intercellular
tunneling
nanotubes.
Collectively,
these
results
only
suggest
regulated
MQC-dependent
manner,
but
also
fulfill
molecular
mechanism
which
MSCs
attenuate
subcellular
organelle
More
importantly,
it
provides
promising
clinical
translation
strategy
based
on
cell-mediated
therapy
mitochondria-related
central
nervous
system
disorders.
Antioxidants,
Год журнала:
2024,
Номер
13(2), С. 240 - 240
Опубликована: Фев. 16, 2024
Neurodegenerative
diseases
(NDs)
encompass
an
assorted
array
of
disorders
such
as
Alzheimer's
disease,
Parkinson's
and
amyotrophic
lateral
sclerosis,
each
characterised
by
distinct
clinical
manifestations
underlying
pathological
mechanisms.
While
some
cases
have
a
genetic
basis,
many
NDs
occur
sporadically.
Despite
their
differences,
these
commonly
feature
chronic
neuroinflammation
hallmark.
Consensus
has
recently
been
reached
on
the
possibility
that
mitochondria
dysfunction
protein
aggregation
can
mutually
contribute
to
activation
neuroinflammatory
response
thus
onset
progression
disorders.
In
present
review,
we
discuss
contribution
aetiology
NDs,
highlighting
new
potential
therapeutic
targets
be
identified
tackle
neurodegenerative
processes
alleviate
pathologies.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(1), С. 380 - 380
Опубликована: Янв. 4, 2025
Plant
secondary
metabolites
(PSMs)
are
a
diverse
group
of
bioactive
compounds,
including
flavonoids,
polyphenols,
saponins,
and
terpenoids,
which
have
been
recognised
for
their
critical
role
in
modulating
cellular
functions.
This
review
provides
comprehensive
analysis
the
effects
PSMs
on
mitochondrial
health,
with
particular
emphasis
therapeutic
potential.
Emerging
evidence
shows
that
these
improve
function
by
reducing
oxidative
stress,
promoting
biogenesis,
regulating
key
processes
such
as
apoptosis
mitophagy.
Mitochondrial
dysfunction,
hallmark
many
pathologies,
neurodegenerative
disorders,
cardiovascular
diseases,
metabolic
syndrome,
has
shown
to
benefit
from
protective
PSMs.
Recent
studies
show
can
dynamics,
stabilise
membranes,
enhance
bioenergetics,
offering
significant
promise
prevention
treatment
mitochondrial-related
diseases.
The
molecular
mechanisms
underlying
effects,
modulation
signalling
pathways
direct
interactions
proteins,
discussed.
integration
into
strategies
is
highlighted
promising
avenue
improving
efficacy
while
minimising
side
commonly
associated
synthetic
drugs.
also
highlights
need
future
research
elucidate
specific
roles
individual
synergistic
within
complex
plant
matrices,
may
further
optimise
utility.
Overall,
this
work
valuable
insights
health
potential
natural
agents
targeting
dysfunction.
Chemical Society Reviews,
Год журнала:
2022,
Номер
52(3), С. 942 - 972
Опубликована: Дек. 14, 2022
Mitochondria
are
inextricably
linked
to
the
development
of
diseases
and
cell
metabolism
disorders.
Super-resolution
imaging
(SRI)
is
crucial
in
enhancing
our
understanding
mitochondrial
ultrafine
structures
functions.
In
addition
high-precision
instruments,
super-resolution
microscopy
relies
heavily
on
fluorescent
materials
with
unique
photophysical
properties.
Small-molecule
fluorogenic
probes
(SMFPs)
have
excellent
properties
that
make
them
ideal
for
SRI.
This
paper
summarizes
recent
advances
field
SMFPs,
a
focus
chemical
spectroscopic
required
Finally,
we
discuss
future
challenges
this
field,
including
design
principles
SMFPs
nanoscopic
techniques.
Cells,
Год журнала:
2023,
Номер
12(17), С. 2183 - 2183
Опубликована: Авг. 30, 2023
Mitochondria
are
the
primary
source
of
energy
production
and
implicated
in
a
wide
range
biological
processes
most
eukaryotic
cells.
Skeletal
muscle
heavily
relies
on
mitochondria
for
supplements.
In
addition
to
being
powerhouse,
evoke
many
functions
skeletal
muscle,
including
regulating
calcium
reactive
oxygen
species
levels.
A
healthy
population
is
necessary
preservation
homeostasis,
while
dysregulation
linked
numerous
myopathies.
this
review,
we
summarize
recent
studies
function
quality
control
focusing
mainly
vivo
rodents
human
subjects.
With
an
emphasis
interplay
between
mitochondrial
concerning
fiber
type-specific
phenotypes,
also
discuss
effect
aging
exercise
remodeling
properties.
Autophagy,
Год журнала:
2024,
Номер
20(12), С. 2655 - 2676
Опубликована: Июль 25, 2024
Spautin-1
is
a
well-known
macroautophagy/autophagy
inhibitor
via
suppressing
the
deubiquitinases
USP10
and
USP13
promoting
degradation
of
PIK3C3/VPS34-BECN1
complex,
while
its
effect
on
selective
autophagy
remains
poorly
understood.
Mitophagy
form
for
removal
damaged
superfluous
mitochondria
autophagy-lysosome
pathway.
Here,
we
report
surprising
discovery
that,
spautin-1
as
an
effective
inhibitor,
it
promotes
PINK1-PRKN-dependent
mitophagy
induced
by
mitochondrial
damage
agents.
Mechanistically,
facilitates
stabilization
activation
full-length
PINK1
at
outer
membrane
(OMM)
binding
to
components
TOMM
complex
(TOMM70
TOMM20),
leading
disruption
import
prevention
PARL-mediated
cleavage.
Moreover,
induces
neuronal
in
