Gene, Год журнала: 2024, Номер unknown, С. 149019 - 149019
Опубликована: Окт. 1, 2024
Язык: Английский
Molecular Cancer, Год журнала: 2024, Номер 23(1)
Опубликована: Сен. 30, 2024
Язык: Английский
Процитировано
20
Journal of Hematology & Oncology, Год журнала: 2024, Номер 17(1)
Опубликована: Авг. 12, 2024
Long non-coding RNAs (lncRNAs), once considered transcriptional noise, have emerged as critical regulators of gene expression and key players in cancer biology. Recent breakthroughs revealed that certain lncRNAs can encode small open reading frame (sORF)-derived peptides, which are now understood to contribute the pathogenesis various cancers. This review synthesizes current knowledge on detection, functional roles, clinical implications lncRNA-encoded peptides cancer. We discuss technological advancements detection validation sORFs, including ribosome profiling mass spectrometry, facilitated discovery these peptides. The roles processes such transcription, translation regulation, signal transduction, metabolic reprogramming explored types potential is highlighted, with a focus their utility diagnostic biomarkers, prognostic indicators, therapeutic targets. challenges future directions translating findings into practice also discussed, need for large-scale validation, development sensitive methods, optimization peptide stability delivery.
Язык: Английский
Процитировано
19
Science Advances, Год журнала: 2023, Номер 9(35)
Опубликована: Сен. 1, 2023
Pattern recognition receptor–mediated innate immunity is critical for host defense against viruses. A growing number of coding and noncoding genes are found to encode microproteins. However, the landscape functions microproteins in responsive virus infection remain uncharacterized. Here, we systematically identified that vesicular stomatitis infection. conserved endoplasmic reticulum–localized membrane microprotein, MAVI1 (microprotein antiviral 1), was interact with mitochondrion-localized MAVS protein inhibit aggregation type I interferon signaling activation. The importance highlighted viral attenuated survival rate increased Mavi1- knockout mice. peptide inhibitor targeting interaction between activated defend Our findings uncovered play roles regulating immune responses, might represent a therapeutic avenue treating
Язык: Английский
Процитировано
12
Cell Death Discovery, Год журнала: 2024, Номер 10(1)
Опубликована: Окт. 23, 2024
Long non-coding RNAs (lncRNAs) are typically described as RNA transcripts exceeding 200 nucleotides in length, which do not code for proteins. Recent advancements technology, including ribosome sequencing and nascent-chain complex sequencing, have demonstrated that many lncRNAs retain small open reading frames can potentially encode micropeptides. Emerging studies revealed these micropeptides, rather than themselves, responsible vital functions, but limited to regulating homeostasis, managing inflammation the immune system, moderating metabolism, influencing tumor progression. In this review, we initially outline rapidly advancing computational analytical methods public tools predict validate potential encoding of lncRNAs. We then focus on diverse functions micropeptides their underlying mechanisms pathogenesis disease. This review aims elucidate lncRNA-encoded explore applications therapeutic targets cancer.
Язык: Английский
Процитировано
5
Cell Death Discovery, Год журнала: 2024, Номер 10(1)
Опубликована: Сен. 27, 2024
Язык: Английский
Процитировано
4
Non-coding RNA Research, Год журнала: 2024, Номер 10, С. 231 - 241
Опубликована: Окт. 30, 2024
Язык: Английский
Процитировано
4
Trends in Genetics, Год журнала: 2024, Номер unknown
Опубликована: Окт. 1, 2024
HighlightsMicroproteins, historically overlooked, are emerging as key players in cancer biology.Advances genomics and proteomics enable systematic identification of cancer-associated microproteins.Microproteins contribute to pathogenesis, an important source cryptic antigens, may offer novel therapeutic targets.Harnessing the potential microproteins could revolutionize diagnostics, therapeutics, immunotherapy.AbstractCancer continues be a major global health challenge, accounting for 10 million deaths annually worldwide. Since inception genome-wide sequencing studies 20 years ago, core set ~700 oncogenes tumor suppressor genes has become basis research. However, this research been based largely on understanding that human genome encodes ~19 500 protein-coding genes. Complementing genomic landscape, recent advances have described numerous which now poised redefine our oncogenic processes open new avenues intervention. This review explores evidence microprotein involvement mechanisms discusses applications, with emphasis highlighting field.
Язык: Английский
Процитировано
3
The EMBO Journal, Год журнала: 2025, Номер unknown
Опубликована: Янв. 28, 2025
Язык: Английский
Процитировано
0
Journal of Hematology & Oncology, Год журнала: 2025, Номер 18(1)
Опубликована: Фев. 19, 2025
In the present era, noncoding RNAs (ncRNAs) have become a subject of considerable scientific interest, with peptides encoded by ncRNAs representing particularly promising avenue investigation. The identification ncRNA-encoded in human cancers is increasing. These regulate cancer progression through multiple molecular mechanisms. Here, we delineate patterns diverse and provide synopsis methodologies employed for that possess capacity to encode these peptides. Furthermore, discuss impacts on biological behavior cells underlying conclusion, describe prospects challenges need be overcome.
Язык: Английский
Процитировано
0
Seminars in Cell and Developmental Biology, Год журнала: 2025, Номер 170, С. 103608 - 103608
Опубликована: Апрель 17, 2025
Язык: Английский
Процитировано
0