Ferroptosis
is
attracting
significant
attention
due
to
its
effectiveness
in
tumor
treatment.
The
efficiency
produce
toxic
lipid
peroxides
(LPOs)
at
the
site
plays
a
key
role
ferroptosis.
A
hybrid
PFP@Fe/Cu-SS
metal
organic
framework
(MOF)
synthesized
and
shown
increase
intratumoral
LPO
content
through
redox
reactions
generating
·OH.
In
addition,
glutathione
(GSH)
depletion
disulfide-thiol
exchange
leads
inactivation
of
peroxide
4
(GPX4),
which
results
further
content.
This
MOF
exhibits
high
inhibitory
effect
on
growth
xenografted
Huh-7
tumors
mice.
coadministration
ferroptosis
inhibitor
reduces
antitumor
MOF,
leading
restoration
GPX4
activity
an
growth.
Moreover,
construction
Cu
into
mesoporous
not
only
allows
be
used
as
contrast
agent
for
T1
-weighted
magnetic
resonance
imaging,
but
also
renders
photothermal
conversion
capacity.
Thus,
near-infrared
irradiation
able
induce
therapy
transform
encapsulated
liquid
perfluoropentane
microbubbles
ultrasound
imaging.
Advanced Functional Materials,
Год журнала:
2019,
Номер
29(9)
Опубликована: Янв. 18, 2019
Abstract
The
wide
clinical
application
of
photodynamic
therapy
(PDT)
is
hampered
by
poor
water
solubility,
low
tumor
selectivity,
and
nonspecific
activation
photosensitizers,
as
well
hypoxia
which
common
for
most
solid
tumors.
To
overcome
these
limitations,
tumor‐targeting,
redox‐activatable,
oxygen
self‐enriched
theranostic
nanoparticles
are
developed
synthesizing
chlorin
e6
(Ce6)
conjugated
hyaluronic
acid
(HA)
with
reducible
disulfide
bonds
(HSC)
encapsulating
perfluorohexane
(PFH)
within
the
(PFH@HSC).
fluorescence
phototoxicity
PFH@HSC
greatly
inhibited
a
self‐quenching
effect
in
an
aqueous
environment.
However,
after
accumulating
tumors
through
passive
active
appear
to
be
activated
from
“OFF”
“ON”
photoactivity
redox‐responsive
destruction
vehicle's
structure.
In
addition,
can
load
lungs
during
blood
circulation,
dissolved
PFH
slowly
released
diffuses
over
entire
tumor,
finally
resulting
remarkable
relief
enhancement
PDT
efficacy
generating
more
singlet
oxygen.
Taking
advantage
excellent
imaging
performance
Ce6,
accumulation
monitored
fluorescent
photoacoustic
intravenous
administration
into
tumor‐bearing
mice.
This
nanoparticle
might
have
good
potential
dual
imaging‐guided
hypoxic
treatment.
ACS Nano,
Год журнала:
2019,
Номер
13(5), С. 5947 - 5958
Опубликована: Апрель 10, 2019
Despite
the
development
of
nanomaterials
with
high-Z
elements
for
radiosensitizers,
most
them
suffer
from
their
oxygen-dependent
behavior
in
hypoxic
tumor,
nonideal
selectivity
to
or
inevasible
damages
normal
tissue,
greatly
limiting
further
applications.
Herein,
we
develop
a
Schottky-type
heterostructure
Au-Bi2S3
promising
ability
reactive
free
radicals
generation
under
X-ray
irradiation
selectively
enhancing
radiotherapeutic
efficacy
by
catalyzing
intracellular
H2O2
tumor.
On
one
hand,
like
many
other
rich
elements,
can
deposit
higher
radiation
dose
within
tumors
form
high
energy
electrons.
remarkably
improve
utilization
large
number
X-ray-induced
low
electrons
during
radiotherapy
nonoxygen
dependent
even
condition.
This
feature
heterostructures
attributes
generated
Schottky
barrier
between
metal
Au
and
semiconductor
Bi2S3,
which
trap
X-ray-generated
transfer
Au,
resulting
efficient
separation
electron-hole
pairs.
Then,
because
matched
potential
conduction
band
Bi2S3
overexpressed
HNSCs
decompose
into
highly
toxic
•OH
selective
radiosensitization
As
consequence,
this
kind
nanoparticle
provides
an
idea
rational
designed
as
radiosensitizers
enhanced
cancer.
Ferroptosis
is
attracting
significant
attention
due
to
its
effectiveness
in
tumor
treatment.
The
efficiency
produce
toxic
lipid
peroxides
(LPOs)
at
the
site
plays
a
key
role
ferroptosis.
A
hybrid
PFP@Fe/Cu-SS
metal
organic
framework
(MOF)
synthesized
and
shown
increase
intratumoral
LPO
content
through
redox
reactions
generating
·OH.
In
addition,
glutathione
(GSH)
depletion
disulfide-thiol
exchange
leads
inactivation
of
peroxide
4
(GPX4),
which
results
further
content.
This
MOF
exhibits
high
inhibitory
effect
on
growth
xenografted
Huh-7
tumors
mice.
coadministration
ferroptosis
inhibitor
reduces
antitumor
MOF,
leading
restoration
GPX4
activity
an
growth.
Moreover,
construction
Cu
into
mesoporous
not
only
allows
be
used
as
contrast
agent
for
T1
-weighted
magnetic
resonance
imaging,
but
also
renders
photothermal
conversion
capacity.
Thus,
near-infrared
irradiation
able
induce
therapy
transform
encapsulated
liquid
perfluoropentane
microbubbles
ultrasound
imaging.
