Advanced Healthcare Materials,
Год журнала:
2021,
Номер
10(12)
Опубликована: Май 21, 2021
Abstract
Lung
cancer
is
one
of
the
most
rapidly
growing
malignancies
in
terms
morbidity
and
mortality.
Although
traditional
treatments
have
been
used
for
more
than
50
years,
it
still
far
from
solving
problems
postoperative
risks
systemic
toxicity.
Emerging
targeting
immunotherapy
are
developing
continuously
gaining
recognition;
eventually,
they
face
inevitable
challenge
drug
resistance.
Nanotechnology
has
several
important
effects
on
lung
treatment,
owing
to
its
unique
properties.
Several
nanoparticle‐based
successfully
become
treatments.
Good
biocompatibility
with
higher
specific
surface
area
can
carry
substantial
amounts
treatment
medications
while
avoiding
medication
toxicity;
editable
modified
characteristics
give
rise
multifunctional
nanomedicines;
excellent
photoelectric
make
a
multimodal
treatment.
This
article
summarizes
breakthroughs
achieved
by
nanotechnology,
targeted
therapy,
immunotherapy,
reflecting
importance
necessity
nanotechnology
cancer.
Chemical Society Reviews,
Год журнала:
2020,
Номер
49(4), С. 1253 - 1321
Опубликована: Янв. 1, 2020
Bismuth-containing
nanomaterials
offer
a
new
opportunity
to
move
beyond
current
achievements
in
the
fields
of
drug
delivery,
diagnosis,
cancer
therapy,
biosensing,
and
tissue
engineering.
This
review
describes
emerging
applications
perspective
these
nanoparticles.
Chemical Society Reviews,
Год журнала:
2019,
Номер
48(11), С. 3073 - 3101
Опубликована: Янв. 1, 2019
X-rays
are
widely
applied
in
clinical
medical
facilities
for
radiotherapy
(RT)
and
biomedical
imaging.
However,
the
sole
use
of
cancer
treatment
leads
to
insufficient
radiation
energy
deposition
due
low
X-ray
attenuation
coefficients
living
tissues
organs,
producing
unavoidable
excessive
doses
with
serious
side
effects
healthy
body
parts.
Over
past
decade,
developments
materials
science
nanotechnology
have
led
rapid
progress
field
X-ray-activated
tumor-targeting
nanosystems,
which
able
tackle
even
systemic
tumors
relieve
burden
exposure
large
doses.
Additionally,
novel
imaging
contrast
agents
techniques
also
been
developed.
In
comparison
conventional
external
light
sources
(e.g.,
near
infrared),
technique
is
ideal
activation
nanosystems
applications
its
nearly
unlimited
penetration
depth
organisms.
this
review,
we
systematically
describe
interaction
mechanisms
between
provide
an
overview
X-ray-sensitive
recent
on
cancer-associated
theranostic
applications.
Abstract
Reactive
oxygen
species
(ROS)
play
an
essential
role
in
physiological
and
pathological
processes.
Studies
on
the
regulation
of
ROS
for
disease
treatments
have
caused
wide
concern,
mainly
involving
topics
ROS‐regulating
therapy
such
as
antioxidant
triggered
by
scavengers
ROS‐induced
toxic
mediated
ROS‐elevation
agents.
Benefiting
from
remarkable
advances
nanotechnology,
a
large
number
nanomaterials
with
ability
are
developed
to
seek
new
effective
ROS‐related
nanotherapeutic
modalities
or
nanomedicines.
Although
considerable
achievements
been
made
ROS‐based
nanomedicines
treatments,
some
fundamental
but
key
questions
rational
design
principle
held
low
regard.
Here,
can
serve
initial
framework
scientists
technicians
optimize
nanomedicines,
thereby
minimizing
gap
biomedical
application
during
stage.
Herein,
overview
current
progress
ROS‐associated
is
summarized.
And
then,
particularly
addressing
these
known
strategies
therapy,
several
principles
presented.
Finally,
future
perspectives
also
discussed
depth
development
ACS Nano,
Год журнала:
2021,
Номер
15(4), С. 6147 - 6191
Опубликована: Март 19, 2021
Janus
nanoparticles
(JNPs)
refer
to
the
integration
of
two
or
more
chemically
discrepant
composites
into
one
structure
system.
Studies
JNPs
have
been
significant
interest
due
their
interesting
characteristics
stemming
from
asymmetric
structures,
which
can
integrate
different
functional
properties
and
perform
synergetic
functions
simultaneously.
Herein,
we
present
recent
progress
particles,
comprehensively
detailing
fabrication
strategies
applications.
First,
classification
is
divided
three
blocks,
consisting
polymeric
composites,
inorganic
hybrid
polymeric/inorganic
composites.
Then,
are
alternately
summarized,
examining
self-assembly
strategy,
phase
separation
seed-mediated
polymerization,
microfluidic
preparation
nucleation
growth
methods,
masking
methods.
Finally,
various
intriguing
applications
presented,
including
solid
surfactants
agents,
micro/nanomotors,
biomedical
such
as
biosensing,
controlled
drug
delivery,
bioimaging,
cancer
therapy,
combined
theranostics.
Furthermore,
challenges
future
works
in
this
field
provided.
Journal of the American Chemical Society,
Год журнала:
2021,
Номер
143(39), С. 16113 - 16127
Опубликована: Сен. 28, 2021
Integrating
multifunctional
nanostructures
capable
of
radiotherapy
and
photothermal
ablation
is
an
emerging
alternative
in
killing
cancer
cells.
In
this
work,
we
report
a
novel
plasmonic
heterostructure
formed
by
decorating
AuPt
nanoparticles
(NPs)
onto
the
surfaces
CuS
nanosheets
(AuPt@CuS
NSs)
as
highly
effective
nanotheranostic
toward
dual-modal
photoacoustic/computed
tomography
imaging
enhanced
synergistic
radiophotothermal
therapy.
These
heterostructures
can
confer
higher
conversion
efficiency
via
local
electromagnetic
enhancement
well
greater
radiation
dose
deposition
form
glutathione
depletion
reactive
oxygen
species
generation.
As
result,
depth
tissue
penetration
improved,
hypoxia
tumor
microenvironment
alleviated.
With
efficacy
radiotherapy,
be
eliminated
without
later
recurrence.
It
believed
that
these
will
play
vital
role
future
oncotherapy
with
effects
under
guided
potential
dual-modality
system.
Exogenous
stimulation
catalytic
therapy
has
received
enormous
attention
as
it
holds
great
promise
to
address
global
medical
issues.
However,
the
therapeutic
effect
of
is
seriously
restricted
by
fast
charge
recombination
and
limited
utilization
exogenous
catalysts.
In
past
few
decades,
many
strategies
have
been
developed
overcome
above
serious
drawbacks,
among
which
heterojunctions
are
most
widely
used
promising
strategy.
This
review
attempts
summarize
recent
progress
in
rational
design
fabrication
heterojunction
nanomedicine,
such
semiconductor-semiconductor
(including
type
I,
II,
III,
PN,
Z-scheme
junctions)
semiconductor-metal
Schottky,
Ohmic,
localized
surface
plasmon
resonance-mediated
junctions).
The
mechanisms
properties
junction
systems
also
discussed
relation
biomedical
applications,
especially
cancer
treatment
sterilization.
concludes
with
a
summary
challenges
some
perspectives
on
future
directions
this
exciting
still
evolving
field
research.
Abstract
Recently,
variable
nanocatalysts
have
provided
novel,
highly
selective,
minimally
invasive
strategies
driven
by
external
physical
fields
for
cancer
therapy.
In
the
catalytic
reaction,
less
toxic
or
nontoxic
substances
can
be
in
situ
converted
into
agents
suppression.
this
review,
we
systematically
summarize
therapy
based
on
different
types
of
fields,
including
light,
ultrasound,
electricity,
temperature,
X‐ray,
magnetic
field,
and
microwave.
The
properties,
mechanisms,
advantages
corresponding
are
also
introduced.
Importantly,
considering
rapid
development
nanomedicine,
research
progress
is
discussed.
Finally,
remaining
challenges
outlooks
that
faced
outlined.
We
believe
emerging
fields‐driven
nanocatalytic
will
provide
a
new
avenue
treatment.
