Bioactive Materials,
Год журнала:
2021,
Номер
7, С. 292 - 323
Опубликована: Июнь 12, 2021
Therapeutic
oligonucleotides
(TOs)
represent
one
of
the
most
promising
drug
candidates
in
targeted
cancer
treatment
due
to
their
high
specificity
and
capability
modulating
cellular
pathways
that
are
not
readily
druggable.
However,
efficiently
delivering
TOs
targets
is
still
biggest
challenge
promoting
clinical
translations.
Emerging
as
a
significant
delivery
vector,
nanoparticles
(NPs)
can
only
protect
from
nuclease
degradation
enhance
tumor
accumulation,
but
also
improve
cell
uptake
efficiency
well
following
endosomal
escape
increase
therapeutic
index.
Furthermore,
on-demand
release
be
approached
minimize
risk
toxicity
towards
normal
tissues
using
stimuli-responsive
NPs.
In
past
decades,
remarkable
progresses
have
been
made
on
based
various
NPs
with
specific
purposes.
this
review,
we
will
first
give
brief
introduction
basis
action
mechanisms
several
typical
TOs,
then
describe
obstacles
prevent
translation
followed
by
comprehensive
overview
recent
types
nanocarriers
containing
lipid-based
nanoparticles,
polymeric
gold
porous
DNA/RNA
nanoassembly,
extracellular
vesicles,
imaging-guided
nanoparticles.
Chemical Society Reviews,
Год журнала:
2021,
Номер
50(10), С. 6013 - 6041
Опубликована: Янв. 1, 2021
In
this
review,
we
systematically
survey
the
most
recent
progress
in
engineering
nanomedicine
for
intracellular
glutathione
consumption-augmented
cancer
therapy.
Advanced Functional Materials,
Год журнала:
2022,
Номер
32(40)
Опубликована: Июль 30, 2022
Abstract
Cuproptosis
is
a
very
newly
recognized
regulated
cell
death
modality
that
distinct
from
known
mechanisms
and
shows
enormous
prospect
in
cancer
treatment.
However,
its
efficacy
copper‐dependent
restricted
by
strictly
copper
metabolism.
Herein,
novel
copper/iron
hybrid
hollow
amorphous
metal
organic
framework
(HaMOF)
developed
as
an
oxidative
stress
amplifier
metabolic
disrupter
for
synergistic
cuproptosis/ferroptosis/apoptosis
anticancer
therapy.
The
HaMOF
fabricated
Cu
2+
,
3,3′‐dithiobis(propionohydrazide)
Fe
3+
via
unsaturated
coordination‐etching
integration
strategy,
then
doxorubicin
loaded
followed
surface
decoration
with
hyaluronan.
obtained
DOX@Fe/CuTH
exhibits
tumor
microenvironment‐triggered
catalytic
therapeutic
property,
wherein
it
can
amplify
cellular
simultaneously
boosting
H
2
O
production
depleting
glutathione.
Moreover,
cause
mitochondrial
dysfunction
downregulate
the
expressions
of
transporter
ATP7A
iron
FPN
1,
thereby
leading
to
disorders
high
retentions
cytoplasm
•OH
generation.
overloaded
lipoylated
protein
dihydrolipoamide
S‐acetyltransferase
aggregation
lead
cuproptosis.
Collectively,
both
augmented
induce
potent
ferroptosis,
which
synergizes
cuproptosis
DOX‐mediated
apoptosis
efficiently
suppress
growth.
This
bimetallic
nanoplatform
provides
new
paradigm
boost
cuproptosis‐related
therapies.
Chemical Society Reviews,
Год журнала:
2023,
Номер
52(6), С. 2031 - 2081
Опубликована: Янв. 1, 2023
Bioactive
materials
are
a
special
class
of
biomaterials
that
can
react
in
vivo
to
induce
biological
response
or
regulate
functions,
thus
achieving
better
curative
effect
than
traditional
inert
biomaterials.
For
cancer
theranostics,
compared
with
organic
polymer
nanomaterials,
inorganic
nanomaterials
possess
unique
physical
and
chemical
properties,
have
stronger
mechanical
stability
on
the
basis
maintaining
certain
bioactivity,
easy
be
compounded
various
carriers
(polymer
carriers,
etc.),
so
as
achieve
specific
antitumor
efficacy.
After
entering
nanoscale,
due
nano-size
effect,
high
surface
area
nanostructures,
exhibit
effects,
which
significantly
influence
interaction
organisms.
Therefore,
research
applications
bioactive
theranostics
attracted
wide
attention.
In
this
review,
we
mainly
summarize
recent
progress
also
introduce
definition,
synthesis
modification
strategies
nanomaterials.
Thereafter,
tumor
imaging
therapy,
including
microenvironment
(TME)
regulation,
catalytic
gas
regulatory
cell
death
immunotherapy,
discussed.
Finally,
biosafety
challenges
mentioned,
their
future
development
opportunities
prospected.
This
review
highlights
bioapplication
Abstract
Nanozyme‐based
chemodynamic
therapy
(CDT)
has
emerged
as
an
effective
cancer
treatment
because
of
its
low
side
effects
and
without
the
requirement
exogenous
energy.
The
therapeutic
effect
CDT
highlights
pivotal
importance
active
sites,
H
2
O
supplement
glutathione
(GSH)
depletion
a
nanozyme.
construction
single
kind
catalyst
with
multiple
functions
for
enhanced
is
still
big
challenge.
In
this
work,
seven
types
bimetallic
nanoparticles
are
synthesized
using
metal–organic
framework
(MOF)
stable
host
instead
Fenton
or
Fenton‐like
ions
supplier.
Among
them,
Cu‐Pd@MIL‐101
alloy
loading
9.5
wt%
modified
by
PEG
(9.5%
CPMP)
found
to
exhibit
highest
peroxidase
(POD)
like
activity
combined
superoxide
dismutase
(SOD)
mimic
function
GSH
depletion.
in
vivo
results
suggest
that
ultrafine
possess
favorable
tumor
good
biosafety
well
biocompatibility.
This
work
provided
credible
strategy
construct
nanozymes
excellent
may
pave
new
way
design
treatment.
ACS Nano,
Год журнала:
2023,
Номер
17(6), С. 5486 - 5502
Опубликована: Март 8, 2023
Lung
cancer
with
the
highest
mortality
poses
a
great
threat
to
human
health.
Ferroptosis
therapy
has
recently
been
raised
as
promising
strategy
for
lung
treatment
by
boosting
reactive
species
(ROS)
production
and
lipid
peroxidation
(LPO)
accumulation
intracellularly.
However,
insufficient
intracellular
ROS
level
unsatisfactory
drug
in
lesions
hamper
efficacy
of
ferroptosis
therapy.
Here,
an
inhalable
biomineralized
liposome
LDM
co-loaded
dihydroartemisinin
(DHA)
pH-responsive
calcium
phosphate
(CaP)
was
constructed
nanoinducer
achieving
Ca2+-burst-centered
endoplasmic
reticulum
(ER)
stress
enhanced
Equipped
excellent
nebulization
properties,
about
6.80-fold
higher
than
intravenous
injection
made
proposed
ideal
nanoplatform
treatment.
The
Fenton-like
reaction
mediated
DHA
peroxide
bridge
structure
could
contribute
induce
ferroptosis.
Assisted
DHA-mediated
sarco-/endoplasmic
ATPase
(SERCA)
inhibition,
initial
Ca2+
burst
caused
CaP
shell
degradation
triggered
Ca2+-mediated
intense
ER
subsequently
induced
mitochondria
dysfunction
further
boost
accumulation,
which
strengthens
second
occurred
result
influx
through
ferroptotic
pores
on
cell
membranes,
thus
sequentially
constructing
lethal
"Ca2+
burst-ER
stress-ferroptosis"
cycle.
Consequently,
process
confirmed
swelling
membrane
disruption
driven
notable
LPO
accumulation.
showed
encouraging
retention
property
extraordinary
antitumor
ability
orthotropic
tumor
murine
model.
In
conclusion,
be
potential
tailored
nebulization-based
pulmonary
delivery
underscore
application
Advanced Materials,
Год журнала:
2023,
Номер
35(30)
Опубликована: Фев. 5, 2023
Therapeutic
DNAzymes
have
unceasingly
intrigued
the
scientific
community
owing
to
their
prosperous
gene
regulation
capability.
The
efficacy
of
against
many
types
diseases
has
been
extensively
studied
for
over
two
decades.
However,
high
expectations
are
still
not
translated
clinic
because
low
effectiveness
in
vivo.
Over
last
five
years,
several
aspects
considered
optimize
DNAzyme-integrated
therapeutics,
including
structural
stability,
mechanism
exploration,
cell
internalization
rate,
cofactor
activation,
and
off-target
effects.
Hence,
this
review
first
discusses
early
monotherapy
design
DNAzymes.
Subsequently,
latest
modes
action
reviewed,
followed
by
an
elaboration
on
stabilization
strategies
considering
catalytic
core
substrate-binding
arms.
DNAzyme-based
synergistic
therapy
is
then
examined,
highlighting
responsive
carrier
construction,
effects,
discovered
advanced
functions,
concerns.
Beyond
this,
key
clinical
advances
elucidated
showcasing
progress.
Finally,
future
trends
development
challenges
DNAzyme-powered
therapeutics
coming
years
discussed
detail.
Advanced
liver
cancer
is
the
most
fatal
malignant
cancer,
and
clinical
outcomes
of
treatment
are
not
very
satisfactory
due
to
complexity
heterogeneity
tumor.
Combination
therapy
can
efficiently
enhance
tumor
by
stimulating
multiple
pathways
regulating
immune
microenvironment.
Nanodrug
delivery
systems
have
become
attractive
candidates
for
combined
strategies
treatment.
This
study
reports
a
nano
ultrasound
contrast
agent
(arsenic
trioxide
(ATO)/PFH
NPs@Au-cRGD)
integrate
diagnosis
efficient
imaging
therapy.
nanodrug
system
promotes
tumor-associated
antigens
release
through
ATO-induced
ferroptosis
photothermal-induced
immunogenic
cell
death,
enhancing
synergistic
effects
ATO
photothermal
in
human
Huh7
mouse
Hepa1-6
cells.
drug
successfully
activates
antitumor
response
macrophage
M1
polarization
microenvironment
with
low
side
subcutaneous
orthotopic
cancer.
Furthermore,
metastasis
inhibited
long-term
immunological
memory
also
established
when
anti-programmed
death-ligand
1
(PD-L1)
immunotherapy.
safe
therapy,
inhibit
lung
metastasis,
achieve
visual
assessment
therapeutic
efficacy,
providing
substantial
potential
clinic
applications
