The Science of The Total Environment, Год журнала: 2024, Номер 943, С. 173821 - 173821
Опубликована: Июнь 12, 2024
Язык: Английский
Journal of Controlled Release, Год журнала: 2022, Номер 349, С. 184 - 205
Опубликована: Июль 8, 2022
Язык: Английский
Процитировано
116
Chemical Reviews, Год журнала: 2022, Номер 123(5), С. 2349 - 2419
Опубликована: Дек. 13, 2022
Recent advances in synthetic biology and materials science have given rise to a new form of materials, namely engineered living (ELMs), which are composed matter or cell communities embedded self-regenerating matrices their own artificial scaffolds. Like natural such as bone, wood, skin, ELMs, possess the functional capabilities organisms, can grow, self-organize, self-repair when needed. They also spontaneously perform programmed biological functions upon sensing external cues. Currently, ELMs show promise for green energy production, bioremediation, disease treatment, fabricating advanced smart materials. This review first introduces dynamic features systems potential developing novel We then summarize recent research progress on emerging design strategies from both perspectives. Finally, we discuss positive impacts promoting sustainability key future directions.
Язык: Английский
Процитировано
114
Advanced Drug Delivery Reviews, Год журнала: 2022, Номер 188, С. 114443 - 114443
Опубликована: Июль 8, 2022
Язык: Английский
Процитировано
98
Nature Reviews Bioengineering, Год журнала: 2023, Номер 1(3), С. 208 - 225
Опубликована: Фев. 2, 2023
Oral administration is a widespread and convenient drug delivery approach. However, oral can be affected by the complex digestive tract environment, including irregular tissue morphology, presence of enzymes, mucus mucosal barriers, spatiotemporal variance in physiological parameters. These obstacles prevent many therapeutics. To overcome these challenges, devices designed with bioinspired compositions, structures or functions to make more drugs available for administration. Various have been developed harnessing biological materials living microorganisms, imitating functions. In this Review, we discuss design modification devices, examining engineering strategies target specific tissues applications. We highlight how key bottlenecks addressed through designs, concluding an outlook on remaining challenges towards clinical translation devices. commonly used strategy deliver harsh environment prevents negatively affect efficacy. This Review discusses microorganisms into that associated delivery.
Язык: Английский
Процитировано
51
Nanomaterials, Год журнала: 2023, Номер 13(15), С. 2185 - 2185
Опубликована: Июль 27, 2023
Probiotics have garnered significant attention in recent years due to their potential advantages diverse biomedical applications, such as acting antimicrobial agents, aiding tissue repair, and treating diseases. These live bacteria must exist appropriate quantities precise locations exert beneficial effects. However, viability activity can be significantly impacted by the surrounding tissue, posing a challenge maintain stability target location for an extended duration. To counter this, researchers formulated various strategies that enhance of probiotics encapsulating them within biomaterials. This approach enables site-specific release, overcoming technical impediments encountered during processing application probiotics. A range materials utilized probiotics, several methods employed this encapsulation process. article reviews advancements encapsulated biomaterials, examining materials, methods, effects encapsulation. It also provides overview hurdles faced currently available biomaterial-based probiotic capsules suggests future research directions field. Despite progress achieved date, numerous challenges persist, necessity developing efficient, reproducible Furthermore, there is need design more robust targeted delivery vehicles.
Язык: Английский
Процитировано
51
Advanced Materials, Год журнала: 2024, Номер 36(18)
Опубликована: Янв. 19, 2024
Manipulation of the gut microbiota using oral microecological preparations has shown great promise in treating various inflammatory disorders. However, delivering these while maintaining their disease-site specificity, stability, and therapeutic efficacy is highly challenging due to dynamic changes associated with pathological microenvironments gastrointestinal tract. Herein, a superior armored probiotic an inflammation-targeting capacity developed enhance timely action bacterial therapy against bowel disease (IBD). The coating strategy exhibits suitability for diverse strains negligible influence on viability. This study demonstrates that probiotics have ultraresistance extreme intraluminal conditions stable mucoadhesive capacity. Notably, HA-functionalized nanoarmor equips inflamed-site targetability through multiple interactions, thus enhancing IBD therapy. Moreover, "awakening" ingested responsive transferrin-directed degradation at site inflammation beneficial therapy, which requires cells be fully functional. Given its easy preparation favorable biocompatibility, single-cell approach provides effective advanced delivery biomedical applications cellular level.
Язык: Английский
Процитировано
34
Food Chemistry X, Год журнала: 2024, Номер 21, С. 101240 - 101240
Опубликована: Фев. 19, 2024
Encapsulation technology has been extensively used to enhance the stability, specificity, and bioavailability of essential food ingredients. Additionally, it plays a vital role in improving product quality reducing production costs. This study presents comprehensive classification encapsulation techniques based on state different cores (solid, liquid, gaseous) offers detailed description analysis these methods. Specifically, introduces diverse applications food, encompassing areas such as antioxidant, protein activity, physical controlled release, delivery, antibacterial, probiotics. The potential impact is expected make major process research hotspot industry. Future directions include for enzymes, microencapsulation biosensors, novel technologies self-assembly. provides valuable theoretical reference in-depth wide application
Язык: Английский
Процитировано
33
Food Hydrocolloids, Год журнала: 2024, Номер 151, С. 109768 - 109768
Опубликована: Янв. 18, 2024
Язык: Английский
Процитировано
21
Advanced Materials, Год журнала: 2024, Номер 36(32)
Опубликована: Янв. 21, 2024
Probiotics with diverse and crucial properties functions have attracted broad interest from many researchers, who adopt intestinal delivery of probiotics to modulate the gut microbiota. However, major problems faced for therapeutic applications are viability colonization during their processing, oral intake, subsequent gut. The challenges simple (stability, controllability, targeting, etc.) greatly limited use in clinical therapies. Nanotechnology can endow be delivered intestine improved survival rate increased resistance adverse environment. Additionally, progress synthetic biology has created new opportunities efficiently purposefully designing manipulating probiotics. In this article, a brief overview types delivery, current different probiotic encapsulation strategies, including chemical, physical, genetic strategies combinations, emerging single-cell using nanocoating methods, is presented. action mechanisms that responsible eliciting beneficial effects also briefly discussed. Finally, engineered discussed, future trends toward developing advanced features health benefits proposed.
Язык: Английский
Процитировано
20
Frontiers in Microbiology, Год журнала: 2025, Номер 15
Опубликована: Янв. 6, 2025
The beneficial properties of probiotics have always been a point interest. Probiotics play major role in maintaining the health Gastrointestinal Tract (GIT), healthy digestive system is responsible for modulating all other functions body. effectiveness can be enhanced by formulating them with prebiotics formulation thus formed referred to as synbiotics. It not only improves viability and stability probiotic cells, but also inhibits growth pathogenic strains. Lactobacillus Bifidobacterium spp. are most commonly used probiotics. microbial that Bacillus, Streptococcus, Enterococcus, Saccharomyces. treatment diabetes, obesity, inflammatory, cardiovascular, respiratory, Central nervous disease (CNS) disorders. essential encapsulate live microorganisms promote intestinal health. Encapsulation safeguards against risks during production, storage, gastrointestinal transit. Heat, pressure, oxidation eradicate their protective qualities. prolongs viability, facilitates regulated release, reduces processing losses, enables application functional food products. microspheres produced through spray drying or coacervation. This technique regulates release gut provides stress resistance. Natural encapsulating materials including sodium alginate, calcium chloride, gel beads polysaccharide promoting process. However, several methods including, where liquid atomized within heated air chamber evaporate moisture produce dry particles efficacy Additionally, vitamins enhance efficacy. immune augmenting generation antibodies immunological cells. combats illnesses enhances immunity. Recent studies indicate may assist regulation weight blood glucose levels influence metabolism insulin sensitivity. Emerging research indicates "gut-brain axis" connects mental alleviate anxiety depression via influencing neurotransmitter synthesis inflammation. Investigations underway about dermatological advantages forecasting onsite delivery probiotics, encapsulation an effective requires more consideration from researchers. review focuses on applications synbiotics prevention human
Язык: Английский
Процитировано
2