Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(16), P. 8306 - 8378
Published: Jan. 1, 2024
As
natural
living
substances,
microorganisms
have
emerged
as
useful
resources
in
medicine
for
creating
microbe-material
hybrids
ranging
from
nano
to
macro
dimensions.
The
engineering
of
microbe-involved
nanomedicine
capitalizes
on
the
distinctive
physiological
attributes
microbes,
particularly
their
intrinsic
"living"
properties
such
hypoxia
tendency
and
oxygen
production
capabilities.
Exploiting
these
remarkable
characteristics
combination
with
other
functional
materials
or
molecules
enables
synergistic
enhancements
that
hold
tremendous
promise
improved
drug
delivery,
site-specific
therapy,
enhanced
monitoring
treatment
outcomes,
presenting
substantial
opportunities
amplifying
efficacy
disease
treatments.
This
comprehensive
review
outlines
microbial
derivatives
used
biomedicine
specific
advantages
therapeutic
application.
In
addition,
we
delineate
fundamental
strategies
mechanisms
employed
constructing
hybrids.
diverse
biomedical
applications
constructed
hybrids,
encompassing
bioimaging,
anti-tumor,
anti-bacteria,
anti-inflammation
diseases
therapy
are
exhaustively
illustrated.
We
also
discuss
current
challenges
prospects
associated
clinical
translation
hybrid
platforms.
Therefore,
unique
versatility
potential
exhibited
by
position
them
promising
candidates
development
next-generation
biomaterials
theranostic
functionalities.
Chemical Reviews,
Journal Year:
2022,
Volume and Issue:
123(5), P. 2349 - 2419
Published: Dec. 13, 2022
Recent
advances
in
synthetic
biology
and
materials
science
have
given
rise
to
a
new
form
of
materials,
namely
engineered
living
(ELMs),
which
are
composed
matter
or
cell
communities
embedded
self-regenerating
matrices
their
own
artificial
scaffolds.
Like
natural
such
as
bone,
wood,
skin,
ELMs,
possess
the
functional
capabilities
organisms,
can
grow,
self-organize,
self-repair
when
needed.
They
also
spontaneously
perform
programmed
biological
functions
upon
sensing
external
cues.
Currently,
ELMs
show
promise
for
green
energy
production,
bioremediation,
disease
treatment,
fabricating
advanced
smart
materials.
This
review
first
introduces
dynamic
features
systems
potential
developing
novel
We
then
summarize
recent
research
progress
on
emerging
design
strategies
from
both
perspectives.
Finally,
we
discuss
positive
impacts
promoting
sustainability
key
future
directions.
Nanomaterials,
Journal Year:
2023,
Volume and Issue:
13(15), P. 2185 - 2185
Published: July 27, 2023
Probiotics
have
garnered
significant
attention
in
recent
years
due
to
their
potential
advantages
diverse
biomedical
applications,
such
as
acting
antimicrobial
agents,
aiding
tissue
repair,
and
treating
diseases.
These
live
bacteria
must
exist
appropriate
quantities
precise
locations
exert
beneficial
effects.
However,
viability
activity
can
be
significantly
impacted
by
the
surrounding
tissue,
posing
a
challenge
maintain
stability
target
location
for
an
extended
duration.
To
counter
this,
researchers
formulated
various
strategies
that
enhance
of
probiotics
encapsulating
them
within
biomaterials.
This
approach
enables
site-specific
release,
overcoming
technical
impediments
encountered
during
processing
application
probiotics.
A
range
materials
utilized
probiotics,
several
methods
employed
this
encapsulation
process.
article
reviews
advancements
encapsulated
biomaterials,
examining
materials,
methods,
effects
encapsulation.
It
also
provides
overview
hurdles
faced
currently
available
biomaterial-based
probiotic
capsules
suggests
future
research
directions
field.
Despite
progress
achieved
date,
numerous
challenges
persist,
necessity
developing
efficient,
reproducible
Furthermore,
there
is
need
design
more
robust
targeted
delivery
vehicles.
Nature Reviews Bioengineering,
Journal Year:
2023,
Volume and Issue:
1(3), P. 208 - 225
Published: Feb. 2, 2023
Oral
administration
is
a
widespread
and
convenient
drug
delivery
approach.
However,
oral
can
be
affected
by
the
complex
digestive
tract
environment,
including
irregular
tissue
morphology,
presence
of
enzymes,
mucus
mucosal
barriers,
spatiotemporal
variance
in
physiological
parameters.
These
obstacles
prevent
many
therapeutics.
To
overcome
these
challenges,
devices
designed
with
bioinspired
compositions,
structures
or
functions
to
make
more
drugs
available
for
administration.
Various
have
been
developed
harnessing
biological
materials
living
microorganisms,
imitating
functions.
In
this
Review,
we
discuss
design
modification
devices,
examining
engineering
strategies
target
specific
tissues
applications.
We
highlight
how
key
bottlenecks
addressed
through
designs,
concluding
an
outlook
on
remaining
challenges
towards
clinical
translation
devices.
commonly
used
strategy
deliver
harsh
environment
prevents
negatively
affect
efficacy.
This
Review
discusses
microorganisms
into
that
associated
delivery.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(18)
Published: Jan. 19, 2024
Manipulation
of
the
gut
microbiota
using
oral
microecological
preparations
has
shown
great
promise
in
treating
various
inflammatory
disorders.
However,
delivering
these
while
maintaining
their
disease-site
specificity,
stability,
and
therapeutic
efficacy
is
highly
challenging
due
to
dynamic
changes
associated
with
pathological
microenvironments
gastrointestinal
tract.
Herein,
a
superior
armored
probiotic
an
inflammation-targeting
capacity
developed
enhance
timely
action
bacterial
therapy
against
bowel
disease
(IBD).
The
coating
strategy
exhibits
suitability
for
diverse
strains
negligible
influence
on
viability.
This
study
demonstrates
that
probiotics
have
ultraresistance
extreme
intraluminal
conditions
stable
mucoadhesive
capacity.
Notably,
HA-functionalized
nanoarmor
equips
inflamed-site
targetability
through
multiple
interactions,
thus
enhancing
IBD
therapy.
Moreover,
"awakening"
ingested
responsive
transferrin-directed
degradation
at
site
inflammation
beneficial
therapy,
which
requires
cells
be
fully
functional.
Given
its
easy
preparation
favorable
biocompatibility,
single-cell
approach
provides
effective
advanced
delivery
biomedical
applications
cellular
level.
Food Chemistry X,
Journal Year:
2024,
Volume and Issue:
21, P. 101240 - 101240
Published: Feb. 19, 2024
Encapsulation
technology
has
been
extensively
used
to
enhance
the
stability,
specificity,
and
bioavailability
of
essential
food
ingredients.
Additionally,
it
plays
a
vital
role
in
improving
product
quality
reducing
production
costs.
This
study
presents
comprehensive
classification
encapsulation
techniques
based
on
state
different
cores
(solid,
liquid,
gaseous)
offers
detailed
description
analysis
these
methods.
Specifically,
introduces
diverse
applications
food,
encompassing
areas
such
as
antioxidant,
protein
activity,
physical
controlled
release,
delivery,
antibacterial,
probiotics.
The
potential
impact
is
expected
make
major
process
research
hotspot
industry.
Future
directions
include
for
enzymes,
microencapsulation
biosensors,
novel
technologies
self-assembly.
provides
valuable
theoretical
reference
in-depth
wide
application
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(32)
Published: Jan. 21, 2024
Probiotics
with
diverse
and
crucial
properties
functions
have
attracted
broad
interest
from
many
researchers,
who
adopt
intestinal
delivery
of
probiotics
to
modulate
the
gut
microbiota.
However,
major
problems
faced
for
therapeutic
applications
are
viability
colonization
during
their
processing,
oral
intake,
subsequent
gut.
The
challenges
simple
(stability,
controllability,
targeting,
etc.)
greatly
limited
use
in
clinical
therapies.
Nanotechnology
can
endow
be
delivered
intestine
improved
survival
rate
increased
resistance
adverse
environment.
Additionally,
progress
synthetic
biology
has
created
new
opportunities
efficiently
purposefully
designing
manipulating
probiotics.
In
this
article,
a
brief
overview
types
delivery,
current
different
probiotic
encapsulation
strategies,
including
chemical,
physical,
genetic
strategies
combinations,
emerging
single-cell
using
nanocoating
methods,
is
presented.
action
mechanisms
that
responsible
eliciting
beneficial
effects
also
briefly
discussed.
Finally,
engineered
discussed,
future
trends
toward
developing
advanced
features
health
benefits
proposed.
Frontiers in Microbiology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 6, 2025
The
beneficial
properties
of
probiotics
have
always
been
a
point
interest.
Probiotics
play
major
role
in
maintaining
the
health
Gastrointestinal
Tract
(GIT),
healthy
digestive
system
is
responsible
for
modulating
all
other
functions
body.
effectiveness
can
be
enhanced
by
formulating
them
with
prebiotics
formulation
thus
formed
referred
to
as
synbiotics.
It
not
only
improves
viability
and
stability
probiotic
cells,
but
also
inhibits
growth
pathogenic
strains.
Lactobacillus
Bifidobacterium
spp.
are
most
commonly
used
probiotics.
microbial
that
Bacillus,
Streptococcus,
Enterococcus,
Saccharomyces.
treatment
diabetes,
obesity,
inflammatory,
cardiovascular,
respiratory,
Central
nervous
disease
(CNS)
disorders.
essential
encapsulate
live
microorganisms
promote
intestinal
health.
Encapsulation
safeguards
against
risks
during
production,
storage,
gastrointestinal
transit.
Heat,
pressure,
oxidation
eradicate
their
protective
qualities.
prolongs
viability,
facilitates
regulated
release,
reduces
processing
losses,
enables
application
functional
food
products.
microspheres
produced
through
spray
drying
or
coacervation.
This
technique
regulates
release
gut
provides
stress
resistance.
Natural
encapsulating
materials
including
sodium
alginate,
calcium
chloride,
gel
beads
polysaccharide
promoting
process.
However,
several
methods
including,
where
liquid
atomized
within
heated
air
chamber
evaporate
moisture
produce
dry
particles
efficacy
Additionally,
vitamins
enhance
efficacy.
immune
augmenting
generation
antibodies
immunological
cells.
combats
illnesses
enhances
immunity.
Recent
studies
indicate
may
assist
regulation
weight
blood
glucose
levels
influence
metabolism
insulin
sensitivity.
Emerging
research
indicates
"gut-brain
axis"
connects
mental
alleviate
anxiety
depression
via
influencing
neurotransmitter
synthesis
inflammation.
Investigations
underway
about
dermatological
advantages
forecasting
onsite
delivery
probiotics,
encapsulation
an
effective
requires
more
consideration
from
researchers.
review
focuses
on
applications
synbiotics
prevention
human
