Advances in Colloid and Interface Science,
Год журнала:
2024,
Номер
330, С. 103207 - 103207
Опубликована: Июнь 3, 2024
To
overcome
the
challenges
of
poor
wound
diagnosis
and
limited
clinical
efficacy
current
management,
dressing
materials
with
aim
monitoring
various
biomarkers
vital
to
healing
process
such
as
temperature,
pH,
glucose
concentration,
reactive
oxygen
species
(ROS)
improving
therapeutic
outcomes
have
been
developed.
These
innovative
theranostic
dressings
are
smartly
engineered
using
stimuli-responsive
biomaterials
monitor
regulate
local
microenvironments
deliver
cargos
sites
in
a
timely
effective
manner.
This
review
provides
an
overview
recent
advances
novel
theranostics
for
therapy
well
giving
insights
into
future
treatment
wounds
via
smart
design
materials.
Advanced Materials,
Год журнала:
2023,
Номер
36(3)
Опубликована: Окт. 18, 2023
Conventional
coupling
agents
(such
as
polyvinylpyrrolidone,
methylcellulose,
and
polyurethane)
are
unable
to
efficiently
transport
drugs
through
the
skin's
dual
barriers
(the
epidermal
cuticle
barrier
basement
membrane
between
epidermis
dermis)
when
exposed
ultrasound,
hindering
deep
noninvasive
transdermal
drug
delivery.
In
this
study,
nanobubbles
prepared
by
double
emulsification
method
aminated
hyaluronic
acid
crosslinked
with
aldehyde-based
dynamic
covalent
bonding
Schiff
base
reaction
produce
an
innovative
ultrasound-nanobubble
agent.
By
amplifying
cavitation
effect
of
can
be
transferred
skin
delivered
layers.
in
vitro
model
isolated
porcine
skin,
agent
achieves
effective
penetration
depth
728
µm
parameters
ultrasound
set
at
2
W,
650
kHz,
50%
duty
cycle
for
20
min.
Consequently,
deeper
layers
noninvasively.
summary,
nanobubble
deep-layer
delivery
ultrasonic
penetrating
barriers,
heralding
a
new
era
platforms
disease
treatment.
Macromolecular Chemistry and Physics,
Год журнала:
2023,
Номер
224(20)
Опубликована: Авг. 12, 2023
Abstract
Dynamic
hydrogels
offer
the
opportunity
to
meet
expectations
of
smart
materials
with
adaptable
properties
such
as
stimuli
responsiveness,
self‐healing,
shear
thinning,
stress
relaxation,
dynamic
viscoelasticity,
energy
dissipation
mechanisms,
time‐dependent
adaptation,
etc.
In
past
decades,
reversible
C═N
bonds
including
imine,
hydrazone,
and
oxime
have
received
great
research
interest
in
design
polymer
networks
(DPNs).
Moreover,
can
be
well‐integrated
into
DPNs
combination
permanent
covalent
crosslinks
and/or
other
(supramolecular
interactions
bonds),
thus
outfitting
enhanced
mechanical
properties,
multiresponsiveness,
printability,
adhesion,
various
functions.
This
literature
review
first
describes
how
introduced
from
perspective
network
topologies.
The
strategies
(building
blocks,
crosslink
type
combinations,
topologies)
reported
are
then
discussed,
well
effects
crosslinking
on
hydrogel
potential
applications.
Advances in Colloid and Interface Science,
Год журнала:
2024,
Номер
330, С. 103207 - 103207
Опубликована: Июнь 3, 2024
To
overcome
the
challenges
of
poor
wound
diagnosis
and
limited
clinical
efficacy
current
management,
dressing
materials
with
aim
monitoring
various
biomarkers
vital
to
healing
process
such
as
temperature,
pH,
glucose
concentration,
reactive
oxygen
species
(ROS)
improving
therapeutic
outcomes
have
been
developed.
These
innovative
theranostic
dressings
are
smartly
engineered
using
stimuli-responsive
biomaterials
monitor
regulate
local
microenvironments
deliver
cargos
sites
in
a
timely
effective
manner.
This
review
provides
an
overview
recent
advances
novel
theranostics
for
therapy
well
giving
insights
into
future
treatment
wounds
via
smart
design
materials.
